Recent Progress in the Design and Application of Strong Metal-Support Interactions in Electrocatalysis.

The strong metal-support interaction (SMSI) in supported metal catalysts represents a crucial factor in the design of highly efficient heterogeneous catalysts. This interaction can modify the surface adsorption state, electronic structure, and coordination environment of the supported metal, altering the interface structure of the catalyst. These changes serve to enhance the catalyst's activity, stability, and reaction selectivity.

Characteristics, Incidence, and Management of Immune Checkpoint Inhibitors Related Cardiovascular Adverse Events in Real-World Practice-A Retrospective Study in Chinese Han Population.

Purpose: This study aimed to elaborate on the incidence, clinical features, and management of immune checkpoint inhibitors (ICIs) related cardiovascular adverse events (CVAEs) in real-world practice.

Patients And Methods: We performed a retrospective chart review study on patients receiving at least one dose of ICI therapy at a Chinese tertiary hospital from March 2020 to March 2021. CVAEs were identified through clinical assessment and the Naranjo algorithm.

5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target.

Metachronous liver metastases (MLM) are characterised by high incidence and high mortality in clinical colorectal cancer treatment. Currently traditional clinical methods cannot effectively predict and prevent the occurrence of metachronous liver metastasis in colorectal cancer. Based on 5hmC-Seal analysis of blood and tissue samples, this study found that portal venous blood was more relevant to tumour gDNA than peripheral blood.

SRF/SLC31A1 signaling promotes cuproptosis induced by celastrol in NSCLC.

Faced with the highly malignant challenge of lung cancer, traditional chemotherapeutic agents, although predominantly inducing apoptosis, are severely limited in their therapeutic effect by the overexpression of anti-apoptotic proteins in lung cancer. Recently discovered copper-induced non-apoptotic cell death, known as cuproptosis, represents a novel mechanism for regulating cell death. Whether Celastrol (Cel), a potential anti-tumor drug, can counter non-small cell lung cancer (NSCLC) through inducing cuproptosis remains to be thoroughly investigated.

Oriented gold nanorods on polyacrylic acid grafted carbon nanotube for efficient SERS detection of cationic dyes.

In this work, we successfully achieved controllable assembly of gold nanorods (AuNRs) into end-to-end orientation using polyacrylic acid (PAA) grafted carbon nanotube (CNT) (i.e., CNT-g-PAA) as a template.

Transcription factor KLF2 is associated with the dysfunctional status of NK cells and the prognosis of pediatric B-ALL patients.

Background: Natural killer cells, an important component of the innate immune system, can directly recognize and lyse virally infected or transformed cells. However, NK cells fail to restrain the growth of malignancies, such as B-cell acute lymphoblastic leukemia (B-ALL). The molecular genetics of NK cells in the B-ALL bone marrow microenvironment and the mechanisms underlying the inhibited function of NK cells at the single-cell level remain largely elusive.

Bilayer electrified-membrane with pair-atom tin catalysts for near-complete conversion of low concentration nitrate to dinitrogen.

Discharge of wastewater containing nitrate (NO) disrupts aquatic ecosystems even at low concentrations. However, selective and rapid reduction of NO at low concentration to dinitrogen (N) is technically challenging. Here, we present an electrified membrane (EM) loaded with Sn pair-atom catalysts for highly efficient NO reduction to N in a single-pass electrofiltration.

TCN-Transformer Deep Network with Random Forest for Prediction of the Chemical Synthetic Ammonia Process.

It is of great significance to realize the accurate prediction of the key output response of the chemical synthetic ammonia process for optimizing system performance and operation monitoring. Because many key intermediate variables of complex systems are difficult to measure comprehensively, there are great difficulties and errors in mechanism analysis and identification modeling techniques. Based on random forest (RF) variable selection, a deep neural network combining temporal convolutional network (TCN) and transformer is proposed to predict the output variables of the synthetic ammonia process.

Ni Single Atoms/FeN Nanoparticles Supported by N-Doped Carbon Hollow Nanododecahedras with Nanotubes on the Surface for Efficient Electro-Reduction of CO to CO.

The transition metal single atoms (SAs)-based catalysts with M-N coordination environment have shown excellent performance in electrocatalytic reduction of CO, and they have received extensive attention in recent years. However, the presence of SAs makes it very difficult to efficiently improve the coordination environment. In this paper, a method of direct high-temperature pyrolysis carbonization of ZIF-8 adsorbed with Ni and Fe ions is reported for the synthesis of Ni SAs and FeN nanoparticles (NPs) supported by the N-doped carbon (NC) hollow nanododecahedras (HNDs) with nanotubes (NTs) on the surface (Ni SAs/FeN NPs@NC-HNDs-NTs).

The mechanism of action of indole-3-propionic acid on bone metabolism.

Indole-3-propionic acid (IPA), a metabolite produced by gut microbiota through tryptophan metabolism, has recently been identified as playing a pivotal role in bone metabolism. IPA promotes osteoblast differentiation by upregulating mitochondrial transcription factor A (Tfam), contributing to increased bone density and supporting bone repair. Simultaneously, it inhibits the formation and activity of osteoclasts, reducing bone resorption, possibly through modulation of the nuclear factor-κB (NF-κB) pathway and downregulation of osteoclast-associated factors, thereby maintaining bone structural integrity.

Biosynthesis of a bacterial meroterpenoid reveals a non-canonical class II meroterpenoid cyclase.

Meroterpenoids are hybrid natural products that arise from the integration of terpenoid and non-terpenoid biosynthetic pathways. While the biosynthesis of fungal meroterpenoids typically follows a well-established sequence of prenylation, epoxidation, and cyclization, the pathways for bacterial perhydrophenanthrene meroterpenoids remain poorly understood. In this study, we report the construction of an engineered metabolic pathway in for the production of the bacterial meroterpenoid, atolypene A (1).

Bivariate tracking of NIR phototherapeutic probe that illuminates the deterioration process of NAFLD-HCC.

Non-alcoholic fatty liver disease (NAFLD) has evolved to become a major cause of hepatocellular carcinoma (HCC). Visualization of NAFLD-HCC deterioration process imaging is essential to understand the underlying pathophysiological processes. However, currently relevant probes with short emission wavelengths, univariate and the inability to achieve theranostics functionality have encountered obstacles in further evaluating the NAFLD-HCC process.

Differential diagnosis of gastric submucosal masses and external pressure lesions.

Lesions of the left triangular ligament of the liver are rare, and there are even fewer cases of vascular tumors misdiagnosed as gastrointestinal stromal tumors. We comment on the two cases reported in the article. The article did not include pictures of laparoscopic surgery, making it unconvincing.

Influences of Community Coalescence on the Assembly of Bacterial Communities of the Small-Scale Complex Aquatic System from the Perspective of Bacterial Transmission, Core Taxa, and Co-occurrence Patterns.

Recirculating aquaculture and aquaponics are considered sustainable aquaculture models playing important roles in animal-derived protein supply. In these aquaculture systems, microorganisms are crucial for the system stability. The community coalescence by mixing substances and microorganisms from various microhabitats under hydraulic forces is important for shaping the bacterial communities in these small-scale complex systems.

Impact of Image Content on Medical Crowdfunding Success: A Machine Learning Approach.

Background: As crowdfunding sites proliferate, visual content often serves as the initial bridge connecting a project to its potential backers, underscoring the importance of image selection in effectively engaging an audience.

Objective: This paper aims to explore the relationship between images and crowdfunding success in cancer-related crowdfunding projects.

Methods: We used the Alibaba Cloud platform to detect individual features in images.

SHORT-ROOT specifically functions in the chalazal region to modulate assimilate partitioning into seeds.

Nourishing the embryo with endosperm and enclosing both embryo and endosperm in the seed coat are two important evolutionary innovations. Seed coat is conventionally viewed as a protective layer that functions after the seed has matured. Here, we challenge this notion by showing that a subregion of the seed coat, termed the chalazal seed coat (CZSC), is geared to gate seed nutrition loading in developing seeds.

Discrimination of Left Atrial Strain Patterns in Hypertensive Heart Disease and Hypertrophic Cardiomyopathy: a Cardiac Magnetic Resonance Feature.

To assess left atrial (LA) strain parameters using cardiovascular magnetic resonance imaging feature tracking (cardiac MRI-FT) for differentiating hypertensive heart disease (HHD) from hypertrophic cardiomyopathy (HCM), which are two left ventricular hypertrophic diseases that could present with similar morphologies in early stage but differ in clinical symptoms and treatment strategies. 45 patients with HHD, 85 patients with HCM (non-obstructive hypertrophic cardiomyopathy [HNCM, n = 45] and obstructive hypertrophic cardiomyopathy [HOCM, n = 40]) and 30 healthy controls (HC) were retrospectively included. LA volumes, strain, and strain rate were determined by manually contouring on the two- and four-chamber views of the CMR-FT module using CVI 42 software.

The JA-to-ABA signaling relay promotes lignin deposition for wound healing in Arabidopsis.

Plants are frequently exposed to herbivory and mechanical damage that result in wounding. Two fundamental strategies, regeneration and healing, are employed by plants upon wounding. How plants make different decisions and how wound healing is sustained until the damaged tissues recover are not fully understood.

Tree Longevity: Multifaceted Genetic Strategies and Beyond.

Old trees are remarkable for their ability to endure for centuries or even millennia, acting as recordkeepers of historical climate and custodians of genetic diversity. The secret to their longevity has long been a subject of fascination. Despite the challenges associated with studying old trees, such as massive size, slow growth rate, long lifespan and often remote habitat, accumulating studies have investigated the mechanisms underlying tree aging and longevity over the past decade.

Stabilizing Fe Single Atoms on Rutile-TiO(110) Surface Via Atomic Substitution.

Stable anchoring of dispersed metal atoms through either surface adsorption or lattice substitution on support surfaces is a prerequisite for highly efficient catalytic performance. Atomic-level insights into these processes are necessary to understand the metal-support interactions. Here, we identify multiple Fe single-atom configurations on the rutile-TiO(110) surface using scanning tunneling microscopy (STM) and density functional theory (DFT).