Publications by authors named "Huimin Mao"

Background: Pulmonary hemorrhage (PH) in respiratory distress syndrome (RDS) in extremely preterm infants exhibits a high mortality rate and poor long-term outcomes. The aim of the present study was to develop a machine learning (ML) predictive model for RDS with PH in extremely preterm infants.

Methods: We performed a retrospective analysis of extremely preterm infants with RDS at the Children's Hospital of Soochow University between January 2015 and January 2021.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how chronic cerebral hypoperfusion (reduced blood flow) due to middle cerebral artery (MCA) issues affects iron metabolism in certain brain regions, particularly in patients with unilateral MCA stenosis or occlusion.
  • They analyzed 61 patients by measuring blood flow patterns and comparing iron levels in specific gray matter regions, categorizing them into three groups based on the extent of hypoperfusion: extensive, regional, and normal.
  • Results showed that higher magnetic susceptibility (indicating iron accumulation) in specific brain regions correlates with worse stroke outcomes, suggesting that abnormal iron metabolism could contribute to neurological deficits following strokes.
View Article and Find Full Text PDF

Rationale And Objectives: Perineural invasion (PNI) is an important prognostic biomarker for prostate cancer (PCa). This study aimed to develop and validate a predictive model integrating biparametric MRI-based deep learning radiomics and clinical characteristics for the non-invasive prediction of PNI in patients with PCa.

Materials And Methods: In this prospective study, 557 PCa patients who underwent preoperative MRI and radical prostatectomy were recruited and randomly divided into the training and the validation cohorts at a ratio of 7:3.

View Article and Find Full Text PDF

Background: As a damage-associated molecular pattern protein, high mobility group box 1 (HMGB1) is associated with kidney and systemic inflammation. The predictive and therapeutic value of HMGB1 as a biomarker has been confirmed in various diseases. However, its value in diabetic kidney disease (DKD) remains unclear.

View Article and Find Full Text PDF

Diabetic vascular complications include diabetic macroangiopathy and diabetic microangiopathy. Diabetic microangiopathy is characterised by impaired microvascular endothelial function, basement membrane thickening, and microthrombosis, which may promote renal, ocular, cardiac, and peripheral system damage in diabetic patients. Therefore, new preventive and therapeutic strategies are urgently required.

View Article and Find Full Text PDF
Article Synopsis
  • - The study focused on creating a quantitative radiomics-based nomogram to better diagnose acute pancreatitis (AP) in children with pancreaticobiliary maljunction (PBM), especially when CT scans show nonobvious signs of the condition.
  • - Researchers reviewed patient data to identify key clinical and radiological features associated with AP, ultimately developing various models that showed strong validity in both training and testing datasets (AUCs ranging from 0.757 to 0.938).
  • - The findings indicate that this new nomogram is a reliable and noninvasive way to diagnose AP in pediatric patients with PBM, even when typical CT signs are absent.
View Article and Find Full Text PDF

Sirtuins, which are NAD-dependent class III histone deacetylases, are involved in various biological processes, including DNA damage repair, immune inflammation, oxidative stress, mitochondrial homeostasis, autophagy, and apoptosis. Sirtuins are essential regulators of cellular function and organismal health. Increasing evidence suggests that the development of age-related diseases, including kidney diseases, is associated with aberrant expression of sirtuins, and that regulation of sirtuins expression and activity can effectively improve kidney function and delay the progression of kidney disease.

View Article and Find Full Text PDF

Protracting lower second molars and uprighting horizontally impacted third molars is a significant orthodontic challenge in patients who require the extraction of severely decayed first molars. Here, we describe the use of biomechanics to upright 90°-tilted lower third molars following second molar protraction. Herein, we introduce a technique for uprighting the lower third molars by (1) the placement of superelastic nickel titanium archwires, (2) bonding, and (3) repositioning of a buccal tube in a tilted position to compensate for the efficiency of Ni-Ti (nickel-titanium) wire.

View Article and Find Full Text PDF

Ethnopharmacological Relevance: Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease and currently there are no specific and effective drugs for its treatment. Podocyte injury is a detrimental feature and the major cause of albuminuria in DN. We previously reported Tangshen Formula (TSF), a Chinese herbal medicine, has shown therapeutic effects on DN.

View Article and Find Full Text PDF

Purpose: To investigate whether moyamoya disease (MMD) and atherosclerotic moyamoya syndrome (AS-MMS) differ in vascular morphology and perfusion characteristics using T1w-CUBE imaging and multiple post-labeling delay 3D pseudo-continuous arterial spin labeling imaging (MP 3D-PcASL), and to explore the potential of the combined techniques for accurate diagnosis of both diseases.

Method: This prospective study enrolled 51 patients with moyamoya vasculopathy, including 26 with MMD and 25 with AS-MMS. All patients underwent digital subtraction angiography (DSA)/magnetic resonance angiography (MRA), T1w-CUBE imaging, and MP 3D-PCASL examinations.

View Article and Find Full Text PDF

High-mobility group protein box 1 (HMGB1) is a member of a highly conserved high-mobility group protein present in all cell types. HMGB1 plays multiple roles both inside and outside the cell, depending on its subcellular localization, context, and post-translational modifications. HMGB1 is also associated with the progression of various diseases.

View Article and Find Full Text PDF

Sirtuins are a family of NAD+ III-dependent histone deacetylases that consists of seven family members, Sirt1-Sirt7, which regulate various signalling pathways and are involved in many critical biological processes of kidney diseases. Traditional Chinese medicine (TCM), as an essential part of the global healthcare system, has multi-component and multi-pathway therapeutic characteristics and plays a role in preventing and controlling various diseases. Through ongoing collaboration with modern medicine, TCM has recently achieved many remarkable advancements in theoretical investigation, mechanistic research, and clinical applications related to kidney diseases.

View Article and Find Full Text PDF

Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a leading cause of end-stage renal disease worldwide. Autophagy plays an important role in maintaining cellular homeostasis in renal physiology. In DKD, the accumulation of advanced glycation end products induces decreased renal autophagy-related protein expression and transcription factor EB (TFEB) nuclear transfer, leading to impaired autophagy and lysosomal function and blockage of autophagic flux.

View Article and Find Full Text PDF

Background: Pancreaticobiliary maljunction (PBM) is a congenital defect, with risk of developing various pancreaticobiliary and hepatic complications. The presentations of PBM in children and adults are believed to be different, but studies on PBM children of different age groups are limited. This study was to evaluate clinicopathologic characteristics and outcomes in PBM children of different ages.

View Article and Find Full Text PDF

Diabetic nephropathy (DN) often leads to end-stage renal disease. Oxidative stress demonstrates a crucial act in the onset and progression of DN, which triggers various pathological processes while promoting the activation of inflammation and forming a vicious oxidative stress-inflammation cycle that induces podocyte injury, extracellular matrix accumulation, glomerulosclerosis, epithelial-mesenchymal transition, renal tubular atrophy, and proteinuria. Conventional treatments for DN have limited efficacy.

View Article and Find Full Text PDF

Purpose: To evaluate the key topics and emerging trends in the field of cardiorenal syndrome type 4 (CRS-4) by bibliometrics and visual analysis.

Methods: Citespace, VOSviewer, and Bibliometrix package were used to analyze the collected data from the Web of Science Core Collection, including publication trends, leading countries, active authors and institutions, co-cited references, journals, and keyword analysis.

Results: Finally, 2267 articles were obtained.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to create machine learning models that can predict surgical risks in children with pancreaticobiliary maljunction (PBM) and biliary dilatation.
  • Conducted on 157 pediatric patients, four ML models (logistic regression, random forest, support vector machine, and extreme gradient boosting) were utilized, with their effectiveness measured using the area under the receiver operator characteristic curve (AUC).
  • The XGBoost model showed the best performance (AUC = 0.822), identifying key predictive factors such as choledochal cyst characteristics and bile duct variations, potentially helping surgeons prevent injuries during surgery.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to create a model predicting post-operative acute pancreatitis (POAP) risk in children with pancreaticobiliary maljunction (PBM) using pre-operative data.
  • Various machine learning techniques, including logistic regression, were utilized to analyze patient data collected from August 2015 to August 2022 at a children's hospital.
  • The logistic regression model emerged as the most effective, highlighting key risk factors such as protein plugs, age, white blood cell count, and common bile duct diameter for predicting POAP.
View Article and Find Full Text PDF

Artemisinin, an antimalarial traditional Chinese herb, is isolated from , and has shown fewer side effects. Several pieces of evidence have demonstrated that artemisinin and its derivatives exhibited therapeutic effects on diseases like malaria, cancer, immune disorders, and inflammatory diseases. Additionally, the antimalarial drugs demonstrated antioxidant and anti-inflammatory activities, regulating the immune system and autophagy and modulating glycolipid metabolism properties, suggesting an alternative for managing kidney disease.

View Article and Find Full Text PDF
Article Synopsis
  • The study aims to develop and validate a nomogram using MR-based radiomics and clinical factors to diagnose liver fibrosis in children with pancreaticobiliary maljunction (PBM), enhancing clinical decision-making and outcomes.
  • A total of 136 PBM patients from two centers were analyzed, with data divided into training and validation sets for accurate assessment of liver fibrosis determined via histopathological examination.
  • The results indicated that two clinical factors and four radiomics features effectively predicted liver fibrosis, with the nomogram demonstrating strong performance across different validation sets, showing clinical promise for patient management.
View Article and Find Full Text PDF

Background: Hemodynamic changes after intracranial artery stenosis (ICAS) or occlusion are important causes of metabolic alterations in tissue. This study aimed to explore the feasibility of using amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI) to diagnose patients with symptomatic chronic ICAS based on pH variations caused by metabolite damage.

Methods: Sixty-seven patients with clinically confirmed unilateral anterior circulation ICAS (≥70% arterial narrowing) and 20 healthy volunteers were recruited for the study.

View Article and Find Full Text PDF

Podocyte injury is a major cause of proteinuria in kidney diseases, and persistent loss of podocytes leads to rapid irreversible progression of kidney disease. Sirtuins, a class of nicotinamide adenine dinucleotide-dependent deacetylases, can promote DNA repair, modify transcription factors, and regulate the cell cycle. Additionally, sirtuins play a critical role in renoprotection, particularly against podocyte injury.

View Article and Find Full Text PDF

Podocyte injury is a common cause of proteinuric kidney diseases. Uncontrollable progressive podocyte loss accelerates glomerulosclerosis and increases the risk of end-stage renal disease. To date, owing to the complex pathological mechanism, effective therapies for podocyte injury have been limited.

View Article and Find Full Text PDF

Sirtuins, as regulators of metabolism and energy, have been found to play an important role in health and disease. Sirt1, the most widely studied member of the sirtuin family, can ameliorate oxidative stress, immune inflammation, autophagy, and mitochondrial homeostasis by deacetylating regulatory histone and nonhistone proteins. Notably, sirt1 has gradually gained attention in kidney disease research.

View Article and Find Full Text PDF

Lotus ( Gaertn.) is a traditional Chinese aquatic flower with high ornamental and economic value, but water salinity seriously affects lotus cultivation and distribution. The Dof transcription factors (TFs) play a crucial function in the regulatory network of growth and defense in plants.

View Article and Find Full Text PDF