Publications by authors named "Huiliu Zhou"
Article Synopsis
- Staphylococcus aureus (S. aureus) is a harmful bacteria that can infect both humans and animals, necessitating a better understanding of its genetic variants to prevent cross-species transmission.
- A genome-wide association study (GWAS) revealed six significant genetic markers (k-mers) that help distinguish S. aureus strains from humans and pigs, achieving a high accuracy rate of 98.12%.
- The study indicates a high risk of transmission between species, with 90% of S. aureus isolated from farm workers traced back to livestock, and highlights differing transmission pathways from humans to pigs and vice versa.
Genome-based model for differentiating between infection and carriage .
Microbiol Spectr
October 2024
Unlabelled: () is a clinically significant opportunistic pathogen, which can colonize multiple body sites in healthy individuals and cause various life-threatening diseases in both children and adults worldwide. The genetic backgrounds of that cause infection versus asymptomatic carriage vary widely, but the potential genetic elements (k-mers) associated with infection remain unknown, which leads to difficulties in differentiating infection isolates from harmless colonizers. Here, we address the disease-associated k-mers by using a comprehensive genome-wide association study (GWAS) to compare the genetic variation of isolates from clinical infection sites (272 isolates) with nasal carriage (240 isolates).
View Article and Find Full Text PDF