Periocular Manifestation of Obstructive Sleep Apnea as a Novel Perioperative Screening Tool.

Purpose: Obstructive sleep apnea (OSA) presents perioperative challenges with increased risk for complications. Floppy eyelid syndrome (FES) is associated with OSA yet has not been addressed perioperatively. The current standard for perioperative OSA screening includes assessing patient risk factors or the STOP-BANG tool, which requires an active participant.

Relative phase effect of nonsequential double ionization of molecules by counter-rotating two-color circularly polarized fields.

Relative phase effect of nonsequential double ionization (NSDI) of aligned molecules by counter-rotating two-color circularly polarized (TCCP) fields is investigated with a three-dimensional classical ensemble model. Numerical results show that NSDI yield in counter-rotating TCCP fields sensitively depends on the relative phase of the two components, which exhibits a sin-like behavior with the period of π/2. NSDI yield achieves its maximum at the relative phase π/8 and minimum at 3π/8.

The Development of a Macromolecular Analgesic for Arthritic Pain.

The addictive potential of clinically used opioids as a result of their direct action on the dopaminergic reward system in the brain has limited their application. In an attempt to reduce negative side effects as well as to improve the overall effectiveness of these analgesics, we have designed, synthesized, and evaluated an N-(2-hydroxypropyl)methacrylamide (HPMA)-based macromolecular prodrug of hydromorphone (HMP), a commonly used opioid. To this end, P-HMP was synthesized via RAFT polymerization and a subsequent polymer analogous reaction.

Prospective Randomized Evaluation of Preoperative Angiotensin-Converting Enzyme Inhibition (PREOP-ACEI).

Background: Intraoperative hypotension is associated with an increased risk of end organ damage and death. The transient preoperative interruption of angiotensinconverting enzyme inhibitor (ACEI) therapy prior to cardiac and vascular surgeries decreases the occurrence of intraoperative hypotension.

Objective: We sought to compare the effect of two protocols for preoperative ACEI management on the risk of intraoperative hypotension among patients undergoing noncardiac, nonvascular surgeries.

[Impacts of pH and surfactants on adsorption behaviors of norfloxacin on marine sediments].

The adsorption behaviors of norfloxacin (NOR) on marine sediments at different pH values and in the presence of four different surfactants were systematically investigated by a batch equilibrium method. The results indicated that Freundlich adsorption isotherms fitted the adsorption behavior of NOR on marine sediments very well at different pH values. The Freundlich constant K(F) and the equilibrium adsorption amount of NOR reduced with the increase of pH values, and the minimum appeared at pH 8.

Performance comparison of laryngoscopy and suction techniques in a hemorrhagic airway manikin simulator: direct laryngoscopy with Yankauer vs. Storz CMAC with attached suction tip.

Airway management of the hemorrhagic airway can be a difficult skill to master as trainee exposure to this difficult airway may be limited. In this study, we employed a hemorrhagic airway simulator along with a videolaryngoscope and the Storz Boedker-Doerges (BD) suction blade. These devices provided improved intubation performance in this model with respect to traditional direct laryngoscope (DL) and VL blades.

Pilot study to determine the utility of point-of-care ultrasound in the assessment of difficult laryngoscopy.

Objectives: Prediction of difficult laryngoscopy in emergency care settings is challenging. The preintubation clinical screening tests may not be applied in a large number of emergency intubations due to the patient's clinical condition. The objectives of this study were 1) to determine the utility of sonographic measurements of thickness of the tongue, anterior neck soft tissue at the level of the hyoid bone, and thyrohyoid membrane in distinguishing difficult and easy laryngoscopies and 2) to examine the association between sonographic measurements (thickness of tongue and anterior neck soft tissue) and difficult airway clinical screening tests (modified Mallampati score, thyromental distance, and interincisor gap).