Nonequilibrium-corrosive engineering synthesis of Pt anchored on FeO with oxygen vacancy for efficient electrocatalytic hydrogen evolution reaction.

The development of suitable support to maximize the atomic utilization efficiency of platinum is of great significance for the hydrogen evolution reaction (HER). Herein, we report a simple and fast nonequilibrium-corrosive approach to prepare oxygen defect-enriched FeO decorated with trace Pt onto nickel-iron foam (Pt/FeO-O/NIF). The Pt/FeO-O/NIF electrode is superhydrophilic with intimate contact with the electrolyte.

CuP/CoP Heterostructure for Efficient Electrosynthesis of Ammonia from Nitrate Reduction Reaction.

Electrocatalytic nitrate reduction (ENORR) for ammonia production is one of the potential alternatives to Haber-Bosch technology for the realization of artificial ammonia synthesis. However, efficient ammonia production remains challenging due to the complex electron transfer process in ENORR. In this study, we fabricated a CuP/CoP heterostructure on carbon cloth (CC) by electrodeposition and vapor deposition, which exhibits an exceptional ENORR performance in alkaline medium, and showcases a Faradaic efficiency of ammonia (FE) and an ammonia yield rate as high as 97.

A Cu/FeO@CN tandem catalyst for efficient ammonia electrosynthesis from nitrate reduction.

Electrochemical nitrate reduction reaction (ENORR) is a green technology for value-added ammonia production meanwhile treating waste water at ambient conditions. However, it remains a great challenge to construct efficient catalysts due to the complex multiple proton and electron transfer process. Herein, we report a tandem catalyst Cu/FeO@CN composed of N-doped carbon layer coated Cu/FeO heterostructure toward highly efficient electrocatalytic nitrate reduction to ammonia production in alkaline medium.

Irregular pulsation on 4D-CTA and quantitative wall enhancement on VW-MRI are associated with symptoms of unruptured intracranial aneurysms.

Background: Unruptured intracranial aneurysms (IAs) that become symptomatic have been associated with instability.

Objective: To investigate the relationship between irregular pulsation on four-dimensional CT angiography (4D-CTA) and aneurysm wall enhancement (AWE) on vessel wall MRI (VW-MRI), and to evaluate their ability to identify symptomatic IAs.

Methods: This retrospective study included consecutive patients with IAs who underwent 4D-CTA and VW-MRI between March 2018 and May 2023.

More powerful dysregulation of Helicobacter pylori East Asian-type CagA on intracellular signalings.

Background: Chronic infection by Helicobacter pylori strains expressing cytotoxin-associated gene A (CagA) are the strongest risk factor for gastric cancer. CagA can be classified into East Asian-type and Western-type (CagA and CagA), with CagA being more closely associated with gastric cancer. This study aimed to investigate the impact of CagA on intracellular signaling pathways to explain its high oncogenicity.

Phenotypic and genetic characterization of daptomycin non-susceptible strains selected by adaptive laboratory evolution.

Background: Daptomycin non-susceptible (DNS) strains pose a serious clinical threat, yet their characteristics remain poorly understood.

Methods: DNS derivatives were generated by exposing strains to subinhibitory concentrations of daptomycin. Competition experiment and growth kinetics experiment were used to observe the growth of bacteria.

LuxS/AI-2 system facilitates the dissemination of antibiotic-resistant plasmids in Klebsiella pneumoniae.

Plasmid conjugation is a central mechanism driving the dissemination of antibiotic resistance in Klebsiella pneumoniae. However, the conjugative operon requires specific stimuli for activation. Identifying signals and elucidating the underlying mechanisms is crucial in combating plasmid spread.

The Biomimetic Electrical Stimulation System Inducing Osteogenic Differentiations of BMSCs.

Electrical stimulation has been used clinically as an adjunct therapy to accelerate the healing of bone defects, and its mechanism requires further investigations. The complexity of the physiological microenvironment makes it challenging to study the effect of electrical signal on cells alone. Therefore, an artificial system mimicking cell microenvironment was developed to address this issue.

Impact of elevated CO on microbial communities and functions in riparian sediments: Role of pollution levels in modulating effects.

The impact of elevated CO levels on microorganisms is a focal point in studying the environmental effects of global climate change. A growing number of studies have demonstrated the importance of the direct effects of elevated CO on microorganisms, which are confounded by indirect effects that are not easily identified. Riparian zones have become key factor in identifying the environmental effects of global climate change because of their special location.

Morphology and Texture-Guided Deep Neural Network for Intracranial Aneurysm Segmentation in 3D TOF-MRA.

This study concentrates on the segmentation of intracranial aneurysms, a pivotal aspect of diagnosis and treatment planning. We aim to overcome the inherent instance imbalance and morphological variability by introducing a novel morphology and texture loss reweighting approach. Our innovative method involves the incorporation of tailored weights within the loss function of deep neural networks.

FeO/ZnO heterojunction for efficient electrochemical nitrate reduction to ammonia.

Electrochemical nitrate reduction to ammonia (ENORR) has attracted great attention owing to its characteristics of treating wastewater while producing high value-added ammonia. In this study, we successfully prepared a heterojunction electrocatalyst FeO/ZnO consisting of FeO nanosheets and ZnO nanoparticles, where the construction of the FeO/ZnO heterojunction not only increased the exposure of the active sites of the catalyst, accelerated the interfacial electron transfer, and improved the conductivity of the catalyst but also optimized its overall electronic structure. Thus, FeO/ZnO demonstrated a high Faraday efficiency of 97.

Helicobacter pylori infection promotes liver injury through an exosome-mediated mechanism.

Helicobacter pylori infection has been thought to be associated with liver diseases, although the exact mechanisms remain elusive. This study identified H. pylori-induced liver inflammation and tissue damage in infected mice and examined the exosome-mediated mechanism underlying H.

Quantifying irregular pulsation of intracranial aneurysms using 4D-CTA.

Recent studies have suggested that irregular pulsation of intracranial aneurysm during the cardiac cycle may be potentially associated with aneurysm rupture risk. However, there is a lack of quantification method for irregular pulsations. This study aims to quantify irregular pulsations by the displacement and strain distribution of the intracranial aneurysm surface during the cardiac cycle using four-dimensional CT angiographic image data.

[Effects of Luhong Yixin Granules on myocardial fibrosis in heart failure rats based on TGF-β1/Smads signaling pathway].

To investigate the effects of Luhong Yixin Granules on myocardial fibrosis in rats with heart failure and its possible mechanism, a total of 60 male Wistar rats were randomly divided into the control group, model group, and low-, medium-and high-dose Luhong Yixin Granules groups, with 12 rats in each group. Except for those in the control group, rats in the other groups were induced by intraperitoneal injection of doxorubicin(DOX) into a rat model. After the Luhong Yixin Granules were dissolved in the same amount of normal saline, they were given by gavage at low, medium and high doses(2.

CuCoO/CuO Heterostructure with Oxygen Vacancies Induced by Plasma for Electrocatalytic Nitrate Reduction to Ammonia.

Electrochemical nitrate reduction (NORR) to ammonia production is regarded as one of the potential alternatives for replacing the Haber-Bosch technology for realizing artificial ammonia synthesis. In this study, a CuCoO/CuO-Ar heterostructure in the shape of dandelion nanospheres formed by nanoarrays has been successfully constructed, demonstrating excellent NORR performance. Experimental results indicate that Ar plasma etching of CuCoO/CuO-Ar significantly increases the content of oxygen vacancies compared to the sample of CuCoO/CuO-Air etched by air plasma, resulting in improved NORR performance.

East Asian type CagA hijacks more SHIP2 by its EPIYA-D motif to potentiate the oncogenicity.

CagA is a significant oncogenic factor injected into host cells by , which is divided into two subtypes: East Asian type (CagA), characterized by the EPIYA-D motif, and western type (CagA), harboring the EPIYA-C motif. CagA has been reported to have higher carcinogenicity than CagA, although the underlying reason is not fully understood. SHIP2 is an intracellular phosphatase that can be recruited by CagA to perturb the homeostasis of intracellular signaling pathways.

Biofilm-producing ability of methicillin-resistant Staphylococcus aureus clinically isolated in China.

Background: Staphylococcus aureus, a commensal bacterium, colonizes the skin and mucous membranes of approximately 30% of the human population. Apart from conventional resistance mechanisms, one of the pathogenic features of S. aureus is its ability to survive in a biofilm state on both biotic and abiotic surfaces.

Optimizing timing for quantification of intracranial aneurysm enhancement: a multi-phase contrast-enhanced vessel wall MRI study.

Objectives: Aneurysm wall enhancement (AWE) on high-resolution contrast-enhanced vessel wall MRI (VWMRI) is an emerging biomarker for intracranial aneurysms (IAs) stability. Quantification methods of AWE in the literature, however, are variable. We aimed to determine the optimal post-contrast timing to quantify AWE in both saccular and fusiform IAs.

A dual-energy computed tomography-based radiomics nomogram for predicting time since stroke onset: a multicenter study.

Objectives: We aimed to develop and validate a radiomics nomogram based on dual-energy computed tomography (DECT) images and clinical features to classify the time since stroke (TSS), which could facilitate stroke decision-making.

Materials And Methods: This retrospective three-center study consecutively included 488 stroke patients who underwent DECT between August 2016 and August 2022. The eligible patients were divided into training, test, and validation cohorts according to the center.

Whitening and antioxidant activities of Extract and development of primary whitening gel products.

Polysaccharides and flavonoids have excellent antioxidant properties and tyrosinase inhibitory effects. In this paper, the antioxidant capacity of extract and its inhibition kinetics on mushroom tyrosinase were investigated to determine the preparation process of primary whitening gel. By conducting experimental studies on the effects of water extract and alcohol extract of on antioxidant capacity and tyrosinase activity, their inhibitory ability and types of inhibitory effects were determined.

Injectable 2D Material-Based Sensor Array for Minimally Invasive Neural Implants.

Intracranial implants for diagnosis and treatment of brain diseases have been developed over the past few decades. However, the platform of conventional implantable devices still relies on invasive probes and bulky sensors in conjunction with large-area craniotomy and provides only limited biometric information. Here, an implantable multi-modal sensor array that can be injected through a small hole in the skull and inherently spread out for conformal contact with the cortical surface is reported.