Publications by authors named "Huilin Wang"

Article Synopsis
  • A study analyzed 26,544 single nucleotide polymorphisms (SNPs) in 291 FRGs and identified 661 SNPs linked to overall survival (OS) in NSCLC patients, later validating these findings in a separate patient group.
  • Two SNPs, FER rs7716388 A>G and SULF1 rs11785839 G>C, were found to be significantly associated with improved survival rates, suggesting that these genetic variants could serve as progn
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Background: The lack of physical activity poses a major challenge to adolescents' healthy physical and mental development. Despite growing attention, research on how the school physical activity climate affects Chinese adolescents' participation in moderate-to-vigorous physical activity (MVPA) remains scarce. This study explores this relationship through the lens of ecological systems theory, focusing on the mediating roles of physical education satisfaction and perceived barriers.

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Introduction: Chinese adolescents are facing tremendous academic pressure and challenges brought about by changes in the social environment, which pose a serious threat to their health-related quality of life (HRQOL). This cross-sectional survey uses convenience and snowball sampling to explore the relationship between adolescents' HRQOL and their participation in moderate-to-vigorous physical activity (MVPA).

Methods: This study subjects include 440 adolescents aged 12 to 18, from four youth training centers and three schools in the central regions of Hunan, Hubei, and Henan provinces, chosen as representative samples for this study.

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Converting CO to methanol is crucial for addressing fuel scarcity and mitigating the greenhouse effect. Cu-based catalysts, with their diverse surface states, offer the potential to control reaction pathways and generate reactive H* species. However, a major challenge lies in oxidizing active Cu species by water generated during the catalytic process.

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Advancing and deploying Fenton-inactive Cd that combines excellent catalytic activity, selectivity, and stability remains a serious challenge, predominantly owing to the difficulty in regulating the intrinsic electronic states and local geometric structures of such fully occupied ds configuration. In this work, a combination of experiments and theoretical calculations reveals that the incorporation of boron (B) enables the tuning of the average oxidation state of Cd to Cd, facilitating electron localization and implementing a different electrocatalytic preference compared to conventional d-electron configurations. The resulting Cd(B) catalyst demonstrates high selectivity (>90% on average) in the O-to-HO conversion, negligible activity loss over 100 h, and a superior HO production rate (15.

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  • T cell exhaustion is linked to decreased effectiveness of immune checkpoint inhibitors in lung cancer, which has the highest mortality rate among cancers, although the genetic variants related to T cell exhaustion in non-small cell lung cancer (NSCLC) prognosis are not well studied.!* -
  • A two-stage analysis using existing genome-wide association study (GWAS) datasets identified 1,721 single nucleotide polymorphisms (SNPs) related to T cell exhaustion that were associated with overall survival in NSCLC patients, with 125 confirmed significant after further validation.!* -
  • Three specific SNPs (rs10493829, rs2239193, and rs3136651) showed a significant association with overall survival, highlighting that certain genotypes
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Objectives: To investigate the diagnostic utility of copy-number variant (CNV) detection by chromosomal microarray analysis (CMA) and genotype-phenotype associations in prenatal congenital anomalies of the kidney and urinary tract (CAKUT).

Methods: This is a retrospective multi-center study of CNV analysis in 457 fetuses with ultrasound-detected CAKUT and normal karyotypes. Cohorts from published studies were included for further pooled analyses (N = 2746).

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Severe viral pneumonia can induce rapid expansion of KRT5+ basal-like cells in small airways and alveoli; this forms a scar-like structure that persists in the injured alveoli and impedes normal alveolar epithelium regeneration. In this study, we investigated the mechanism by which viral infection induced this remodeling response. Through comparing different lung-injury models, we demonstrated that infection induced strong IFN-γ signal-stimulated dysplastic KRT5+ cell formation.

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Introduction: Penalty shootouts are a pivotal factor influencing outcomes in soccer matches. Soccer players face the challenge of overcoming physical fatigue and psychological pressure when taking penalty kicks. Instances of low confidence and competitive state anxiety during matches exacerbate the detrimental impact on attention control, particularly in non-target defined features, leading to suboptimal performance during penalty kicks.

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Ferroptosis, a form of regulated cell death, is characterized by iron-dependent lipid peroxidation. It is recognized increasingly for its pivotal role in both cancer development and the response to cancer treatments. We assessed associations between 370,027 single-nucleotide polymorphisms (SNPs) within 467 ferroptosis-related genes and survival of non-small cell lung cancer (NSCLC) patients.

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  • The study investigates how two genes, PagHAM4a and PagHAM4b, regulate the formation of secondary xylem, which is crucial for tree biomass production.
  • Overexpressing these genes boosts cambial activity and increases the number of xylem cells, while mutations lead to decreased activity and reduced xylem.
  • The research uncovers distinct gene networks controlled by PagHAM4a and PagHAM4b, highlighting their roles in promoting cambial differentiation into secondary xylem.
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  • This study looks at how money management (financialization) affects businesses' ability to come up with new ideas (innovation).
  • It uses a special game model to understand how companies invest and compete in the market.
  • The results show that when companies focus too much on financialization, it can actually slow down their innovation efforts, especially in China from 2009 to 2021.
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  • B cells are important in cancer progression, particularly non-small cell lung cancer (NSCLC), but the impact of genetic variants in immunity-related genes on patient survival is unclear.
  • The study analyzed over 10,000 genetic variants in B cell-related genes among nearly 1,200 NSCLC patients and identified 369 single nucleotide polymorphisms (SNPs) linked to overall survival, further validating 18 SNPs in an additional patient group.
  • Two specific SNPs were found to significantly influence patient survival, with certain unfavorable combinations of these genotypes leading to poorer outcomes, and gene expression analyses indicated that specific alleles correlate with higher gene activity in lung tissues.
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Introduction: The lack of physical exercise is a global health concern, particularly affecting women. However, there is limited research on factors influencing women's sports participation. Recent studies on increasing women's physical activity levels differ in methodologies and conclusions.

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  • Hypoxia plays a significant role in cancer aggression, impacting processes like blood vessel formation and immune response, yet the influence of genetic variants in hypoxia-related genes on survival in non-small cell lung cancer (NSCLC) remains unclear.
  • Researchers studied 16,092 single-nucleotide polymorphisms (SNPs) in 182 hypoxia-related genes among NSCLC patients, using data from two cancer studies to identify any survival associations.
  • They found that the ERRFI1 gene variant rs28624 was linked to lower overall survival rates in patients, indicating that certain genetic variations could affect how long individuals with NSCLC live, possibly by influencing gene expression.
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  • This study investigates the use of marine bacterial metalloprotease A69 to create bioactive peptides from peanut proteins that demonstrate antioxidant and ACE-inhibitory activities.
  • The optimized process involved hydrolyzing peanut protein at specific conditions (3000 U/g, 60°C, pH 7.0 for 4 hours), resulting in peptides with low molecular weights and a diverse amino acid profile.
  • The prepared peanut peptides showed strong antioxidant activity and significant ACE-inhibition, highlighting their nutritional benefits and the potential of protease A69 for producing functional food ingredients.
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Type 1 diabetes (T1D) is a specific autoimmune disease related to genetic and autoimmune factors. Recent studies have found that the intestinal flora is one of the important environmental factors in the development of T1D. The gut microbiota is the largest microbiota in the human body and has a significant impact on material and energy metabolism.

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The sudden onset of the coronavirus disease 2019 (COVID-19) in January 2020 has affected essential global health services. Cancer-screening services that can reduce cancer mortality are strongly affected. However, the specific role of COVID-19 in cancer screening is not fully understood.

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Introduction: Adolescence is considered a stress-sensitive developmental period, and the escalating and sustained pressure during this phase poses a significant threat to the mental and physical well-being of adolescents. Therefore, enhancing positive emotions in adolescents is crucial. This study aims to investigate the impact of physical activity on the emotional intelligence, interpersonal forgiveness, and positive emotions of adolescents.

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Introduction: Athletes, due to frequent physical interactions in competitive sports, are prone to impulsive behavior. Impulsive behavior is a prevalent psychological factor in sports, often leading to performance-affecting errors. This cross-sectional survey investigated the relationship between mindfulness and athletes' impulsive behavior.

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Introduction: In the current trend toward youthfulness and age reduction in competitive sports, the issue of obligatory exercise among young athletes is becoming more severe. This not only affects their physical and mental health but also hampers their future prospects in the sports world. While delving into the impact of mindfulness on the issue of obligatory exercise among young athletes, it reveals the mediating role of obsessive passion and cognitive state anxiety.

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The mulberry plant is a member of the Moraceae family and belongs to the genus. Its entire body is a treasure, with mulberries, mulberry leaves, and mulberry branches all suitable for medicinal use. The main active ingredient in mulberries is mulberry polysaccharide.

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Purpose: The family decision-makers serve as the backbone of the family, and their health status warrants consideration. This study aims to explore how the health status of this group of people, namely the family decision-making group, is affected, and to delve into the mechanisms of influence based on this. The goal is to provide reliable evidence and strategies for the health management of the family decision-makers group, contributing to the achievement of the "Healthy China 2030" Planning Outline.

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