Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway.

Trichothecene macrolides comprise a class of valuable leading compounds in developing anticancer drugs, however, there are few reports concerning their anticancer mechanisms, especially the anticancer mechanism of the 10,13-cyclotrichothecane derivatives that are found mainly in symbiotic fungi. In vitro anticancer activity of two trichothecene macrolides mytoxin B and myrothecine A against the human hepatocarcinoma cell line SMMC-7721 was investigated in the present study. MTT assay showed that mytoxin B and myrothecine A inhibited the proliferation of SMMC-7721 cells in dose- and time-dependent manners.

Cytotoxic Tricycloalternarene Compounds from Endophyte sp. W-1 Associated with .

The chemical investigation of the culture filtrate of endophyte sp. W-1 associated with provided a new tricycloalternarene compound, 2H-(2)-tricycloalternarene 12a (), together with five known analogs: (2)-tricycloalternarene 12a (), tricycloalternarene 3a (), tricycloalternarene F (), 15-hydroxyl tricycloalternarene 5b (), and ACTG-Toxin D (). In vitro cytotoxicity against the human hepatocellular carcinoma cell line SMMC-7721 and the human gastric carcinoma cell line SGC-7901 was evaluated by the MTT method.