Causal associations between fluid intake patterns and dermatitis risk: a Mendelian randomization study.

Background: Dermatitis is one of the most common skin disorders across the world. Atopic dermatitis (AD) and contact dermatitis (CD) are its two primary types. Few studies have focused on the causal relationship between fluid intake and dermatitis.

Corals-inspired magnetic absorbents for fast and efficient removal of microplastics in various water sources.

Microplastics (MPs) as the formidable pollutants with high toxicity and difficult degradation may threaten the aquaculture industry and human health, making it highly necessary to develop the effective removal methods. In this article, FeO nanoparticles (NPs) were initially fabricated with mesoporous structure, but showing undesirable adsorption efficiencies for the adsorption of MPs (lower than 70%). Inspired by the reefs-rebuilding corals acting as the sinks for various marine pollutants like plastic, FeO NPs were coated further with adhesive polymerized dopamine (PDA) yielding FeO@PDA absorbents.

A selective colorimetric and efficient removal strategy for mercury(II) in aquatic systems using mesoporous FeO-loaded silver probes.

Mesoporous FeO-loaded silver nanocomposites (FeO@Ag) were simply fabricated as bi-functional nanozymes for the catalysis-based detection and removal of Hg ions. It was found that the as-prepared magnetic FeO@Ag could display peroxidase-like catalysis activity that could be rationally enhanced in the presence of Hg ions. To our surprise, the shell of the Ag element may decrease the catalysis of the FeO to some degree.

High-quality assembled and annotated genomes of Nicotiana tabacum and Nicotiana benthamiana reveal chromosome evolution and changes in defense arsenals.

Nicotiana tabacum and Nicotiana benthamiana are widely used models in plant biology research. However, genomic studies of these species have lagged. Here we report the chromosome-level reference genome assemblies for N.

Screening for Resistance Resources against Bacterial Wilt in Wild Potato.

Potato is an important crop, used not only for food production but also for various industrial applications. With the introduction of the potato as a staple food strategy, the potato industry in China has grown rapidly. However, issues related to bacterial wilt, exacerbated by factors such as seed potato transportation and continuous cropping, have become increasingly severe in the primary potato cultivation regions of China, leading to significant economic losses.

StMLP1, as a Kunitz trypsin inhibitor, enhances potato resistance and specifically expresses in vascular bundles during Ralstonia solanacearum infection.

Miraculin-like proteins (MLPs), members of the Kunitz trypsin inhibitor (KTI) family that are present in various plants, have been discovered to have a role in defending plants against pathogens. In this study, we identified a gene StMLP1 in potato that belongs to the KTI family. We found that the expression of StMLP1 gradually increases during Ralstonia solanacearum (R.

type III effector RipAS associates with potato type one protein phosphatase StTOPP6 to promote bacterial wilt.

The bacterial pathogen () delivered type III secretion effectors to inhibit the immune system and cause bacterial wilt on potato. Protein phosphatases are key regulators in plant immunity, which pathogens can manipulate to alter host processes. Here, we show that a type III effector RipAS can reduce the nucleolar accumulation of a type one protein phosphatase (PP1) StTOPP6 to promote bacterial wilt.

A novel effector RipBT contributes to Ralstonia solanacearum virulence on potato.

Ralstonia solanacearum is one of the most destructive plant-pathogenic bacteria, infecting more than 200 plant species, including potato (Solanum tuberosum) and many other solanaceous crops. R. solanacearum has numerous pathogenicity factors, and type III effectors secreted through type III secretion system (T3SS) are key factors to counteract host immunity.

Protein phosphatase StTOPP6 negatively regulates potato bacterial wilt resistance by modulating MAPK signaling.

Potato (Solanum tuberosum) is an important crop globally and is grown across many regions in China, where it ranks fourth in the list of staple foods. However, its production and quality are severely affected by bacterial wilt caused by Ralstonia solanacearum. In this study, we identified StTOPP6, which belongs to the type one protein phosphatase (TOPP) family, and found that transient knock down of StTOPP6 in potato increased resistance against R.

Comparative genomic analysis of reveals candidate avirulence effectors in HA4-1 triggering wild potato immunity.

is the causal agent of potato bacterial wilt, a major potato bacterial disease. Among the pathogenicity determinants, the Type III Secretion System Effectors (T3Es) play a vital role in the interaction. Investigating the avirulent T3Es recognized by host resistance proteins is an effective method to uncover the resistance mechanism of potato against .

Comparative transcriptome analysis revealed molecular mechanisms of peanut leaves responding to and its type III secretion system mutant.

Bacterial wilt caused by is a serious soil-borne disease that limits peanut production and quality, but the molecular mechanisms of the peanut response to remain unclear. In this study, we reported the first work analyzing the transcriptomic changes of the resistant and susceptible peanut leaves infected with HA4-1 and its type III secretion system mutant strains by the cutting leaf method at different timepoints (0, 24, 36, and 72 h post inoculation). A total of 125,978 differentially expressed genes (DEGs) were identified and subsequently classified into six groups to analyze, including resistance-response genes, susceptibility-response genes, PAMPs induced resistance-response genes, PAMPs induced susceptibility-response genes, T3Es induced resistance-response genes, and T3Es induced susceptibility-response genes.

Complete Genome Sequence Analysis of Strain PeaFJ1 Provides Insights Into Its Strong Virulence in Peanut Plants.

The bacterial wilt of peanut ( L.) caused by is a devastating soil-borne disease that seriously restricted the world peanut production. However, the molecular mechanism of peanut interaction remains largely unknown.

Heterologous overexpression of StERF3 triggers cell death in Nicotiana benthamiana.

Programmed cell death plays a crucial role in plant development and disease defense. Here, we report that the expression of StERF3, a potato EAR motif-containing transcription factor, promotes Phytophthora infestans colonization in Nicotiana benthamiana. Transient overexpression of StERF3 induces cell death in N.

Obesity-Related Glomerulopathy: From Mechanism to Therapeutic Target.

Obesity-related glomerulopathy (ORG) is a secondary glomerular disease caused by obesity, with clinical manifestations such as proteinuria and glomerulomegaly. Currently, the high incidence of obesity brings a change in the spectrum of kidney diseases across the globe, including China. ORG has become another important secondary nephropathy leading to end-stage renal disease (ESRD), and its incidence has increased significantly.

Ralstonia solanacearum type III effector RipV2 encoding a novel E3 ubiquitin ligase (NEL) is required for full virulence by suppressing plant PAMP-triggered immunity.

Ralstonia solanacearum causes bacterial wilt disease in a broad range of plants, primarily through type Ⅲ secreted effectors. However, the R. solanacearum effectors promoting susceptibility in host plants remain limited.

Proteomic Analysis of Potato Responding to the Invasion of UW551 and Its Type III Secretion System Mutant.

The infection of potato with UW551 gives rise to bacterial wilt disease via colonization of roots. The type III secretion system (T3SS) is a determinant factor for the pathogenicity of . To fully understand perturbations in potato by type III effectors(T3Es), we used proteomics to measure differences in potato root protein abundance after inoculation with UW551 and the T3SS mutant (UW551△V).

A metal-free and preconcentration-free method for non-enzymatic amperometric determination of pentachlorophenol using a ZIF-derived hollow carbon material.

An enzyme-free, metal-free, and preconcentration-free electrochemical sensor for pentachlorophenol assay has been fabricated. The interface of the sensor is based on a hollow zeolitic imidazolate framework-derived mesoporous carbon material (denoted as HZC/SPCE). The sensor exhibits linear amperometric response upon pentachlorophenol at 0.

Measles re-emerges and recommendation of vaccination.

Measles is a highly infectious viral illness and is one of the world's most contagious diseases that can affect all people if they have not been vaccinated or have not had it before. Before measles vaccine became available in 1963, major epidemic occurred approximately every 2 to 3 years and thus 99% of the people were thought to have been infected naturally with measles virus and got immune for life. In 2000, measles was declared eliminated from the United States, and yet 1215 cases have been reported from 30 states as of August 22, 2019.

[Determination of nine pesticide residues in honey using high performance liquid chromatography-tandem mass spectrometry].

A method is proposed for the simultaneous determination of nine benzimidazole and neonicotinoid pesticides present in honey by employing automatic solid-phase extraction with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). A honey sample was dissolved in a phosphate buffer (pH=7.8) followed by ultrasonic extraction.

A systematic screen of conserved Ralstonia solanacearum effectors reveals the role of RipAB, a nuclear-localized effector that suppresses immune responses in potato.

Both Solanum tuberosum and Ralstonia solanacearum phylotype IIB originated in South America and share a long-term co-evolutionary history. However, our knowledge of potato bacterial wilt pathogenesis is scarce as a result of the technical difficulties of potato plant manipulation. Thus, we established a multiple screening system (virulence screen of effector mutants in potato, growth inhibition of yeast and transient expression in Nicotiana benthamiana) of core type III effectors (T3Es) of a major potato pathovar of phylotype IIB, to provide more research perspectives and biological tools.

Fabricating carbon-nanotubes-based porous foam for superoxide electrochemical sensing through one-step hydrothermal process induced by phytic acid.

The detection of superoxide anions (O) is widely considered as a potential way for cancer diagnosis and the development of enzyme-mimic catalysts is the main challenge in the establishment of electrochemical sensors for O sensing in real samples. Here we present a novel enzyme- and metal-free electrochemical catalyst for superoxide (O) sensing based on the widely-used carbon nanotubes (CNT). Through a one-step hydrothermal process induced by phytic acid (PA), CNT-based porous foam (PACNTF) was successfully obtained.

3D graphene-based foam induced by phytic acid: An effective enzyme-mimic catalyst for electrochemical detection of cell-released superoxide anion.

Here we present a new method to fabricate enzyme-mimic metal-free catalysts for electrochemical detection of superoxide anion (O) by introducing phosphate groups into graphene-based foam. Through a template-free hydrothermal process, graphene oxide (GO) was treated with different amount of phytic acid (PA) to obtain 3D porous graphene-based foam (PAGF). Characterizations demonstrate that phosphate groups were successfully modified on the surface and inter layer structure of PAGF materials and the defects and disorder degree of PAGF could be controlled by adjusting the addition of PA precursors.

Expression of MMP-2 and TIMP-1 in cerebrospinal fluid and the correlation with dynamic changes of serum PCT in neonatal purulent meningitis.

Matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in cerebrospinal fluid of pediatric patients with neonatal purulent meningitis were observed to analyze changes in serum procalcitonin (PCT) and the correlation among the three factors (MMP-2, TIMP-1 and PCT). Sixty pediatric patients with neonatal purulent meningitis from April 2015 to December 2016 were enrolled as the purulent meningitis group and 60 pediatric patients with viral encephalitis treated during the same period were enrolled as the viral encephalitis group. Additionally, 60 healthy newborns who underwent physical examinations in our hospital during the same period were enrolled as the control group.

Bacterial Wilt in China: History, Current Status, and Future Perspectives.

Bacterial wilt caused by plant pathogenic spp. is one of the most important diseases affecting the production of many important crops worldwide. In China, a large scientific community has been dedicated to studying bacterial wilt and its causative agent, and .