. protects glomerular endothelial cells via the miR155-H2AC6 interaction network in hypertensive renal injury.

Background: Hypertensive renal injury is one of the most lethal complications of hypertension. At present, renin-angiotensin-aldosterone system (RAAS) blockers are considered the best drugs for the treatment of renal injury in hypertension because of their nephroprotective effect of reducing proteinuria, but there are no specific drugs for this purpose, however, clinical trials proved that Chinese medicine has a protective effect on target organs in the treatment of hypertension. .

Prognostic value of microRNAs in heart failure: A meta-analysis.

Background: Reported studies have shown that expression levels of microRNAs (miRNAs) are related to survival time of patients with heart failure (HF). A systematic review and meta-analysis were conducted to study circulating miRNAs expression and patient outcome.

Methods: Meta-analysis estimating expression levels of circulating miRNAs in HF patients from January 2010 until June 30, 2018, through conducting online searches in Pub Med, Cochrane Database of Systematic, EMBASE and Web of Science and reviewed by 2 independent researchers.

Similar potential of foliar δC and silicon levels for inferring local climate information in the Tibetan Plateau region.

Stable carbon isotope ratios (δC) are widely used as climate proxies for assessing and predicting climatic information at an annual resolution. However, the detailed information in the isotopes that results from intra-annual climate scenarios and is associated with mineral accumulation remains unclear. Combined with investigations of elements and ash contents, variations in foliar δC in relation to annual, winter and summer climate scenarios were investigated in a dendroclimatologically important tree species Sabina przewalskii Kom.

The Arabidopsis MutS homolog AtMSH5 is required for normal meiosis.

MSH5, a member of the MutS homolog DNA mismatch repair protein family, has been shown to be required for proper homologous chromosome recombination in diverse organisms such as mouse, budding yeast and Caenorhabditis elegans. In this paper, we show that a mutant Arabidopsis plant carrying the putative disrupted AtMSH5 gene exhibits defects during meiotic division, producing a proportion of nonviable pollen grains and abnormal embryo sacs, and thereby leading to a decrease in fertility. AtMSH5 expression is confined to meiotic floral buds, which is consistent with a possible role during meiosis.