Diagnostic value of combined FVC%/DLCO% and echocardiography in connective tissue disorder‑associated pulmonary hypertension.

The main objective of the present study was to investigate whether forced vital capacity (FVC)%/diffusing capacity of the lungs for carbon monoxide (DLCO)% can be used to predict the presence of pulmonary hypertension (PH) in connective tissue disorders (CTDs). For this purpose, a total of 53 individuals who were diagnosed with CTDs and had undergone right heart catheterization between July, 2019 and July, 2022 were included in the present study. Based on the mean pulmonary artery pressure (mPAP) measured during right heart catheterization, the participants were divided into the PH and non-PH groups.

Palladium-Catalyzed Regioselective C4-H Acyloxylation of Indoles with Carboxylic Acids via a Transient Directing Groups Strategy.

The development of an efficient method for the synthesis of C4 oxy-substituted indoles is an appealing yet challenging task. Herein, we report a general palladium-catalyzed TDG approach for the direct C4-H acyloxylation of indoles. The protocol features atom and step economy, excellent regioselectivity, and good tolerance of functional groups.

Effects of motor-cognitive interaction based on dual-task gait analysis recognition in middle age to aging people with normal cognition and mild cognitive impairment.

Background: Mild cognitive impairment (MCI) is considered a transitional stage between cognitive normality and dementia among the elderly, and its associated risk of developing Alzheimer's disease (AD) is 10-15 times higher than that of the general population. MCI is an important threshold for the prevention and control of AD, and intervention in the MCI stage may be the most effective strategy to delay the occurrence of AD.

Materials And Methods: In this study, 68 subjects who met the inclusion criteria were divided into an MCI group (38 subjects) and normal elderly (NE) group (30 subjects).

Palladium-catalyzed phosphorylation of arylsulfonium salts with P(O)H compounds C-S bond cleavage.

Herein we report a novel palladium-catalyzed phosphorylation of arylsulfonium salts with P(O)H compounds C-S bond cleavage under mild conditions. The protocol provides a pragmatic strategy applicable to the synthesis of diverse arylphosphonates.

Self-assembled sonogels formed from 1,4-naphthalenedicarbonyldinicotinic acid hydrazide.

In this paper, we report self-assembled sonogels formed from 1,4-naphthalenedicarbonyldinicotinic acid hydrazide (NDC-NN3) in some liquids including ethanol, tetrahydrofuran (THF), 1,4-dioxane, -propanol, -butanol and -pentanol. When the clear solution of NDC-NN3 in the selected liquids mentioned above at a suitable concentration was irradiated with ultrasound waves at room temperature, a sonogel was formed. Upon heating, the sonogel dissolved gradually and finally became a clear solution again.

Supramolecular gel formation regulated by water content in organic solvents: self-assembly mechanism and biomedical applications.

As one of the most important and fruitful methods, supramolecular self-assembly has a significant advantage in designing and fabricating functional soft materials with various nanostructures. In this research, a low-molecular-weight gelator, ,'-di(pyridin-4-yl)-pyridine-3,5-dicarboxamide (PDA-N4), was synthesized and used to construct self-assembled gels a solvent-mediated strategy. It was found that PDA-N4 could form supramolecular gels in mixed solvents of water and DMSO (or DMF) at high water fraction (greater than or equal to 50%).

Hydrothermal liquefaction of Ulva prolifera macroalgae and the influence of base catalysts on products.

Hydrothermal liquefaction of Ulva prolifera macroalgae (UM), an aquatic biomass, was carried out in an autoclave reactor at different temperature (270, 290 and 310 °C) and reaction holding time (10, 20 and 30 min.). The catalytic reactions of UM were carried out in the presence of three basic catalysts (KOH, NaOH and NaCO) with the different catalyst amount.

A pH-/thermo-responsive hydrogel formed from ,'-dibenzoyl-l-cystine: properties, self-assembly structure and release behavior of SA.

In this study, we report a pH-/thermo-responsive hydrogel formed by ,'-dibenzoyl-l-cystine (DBC). It is difficult to dissolve DBC in water even on heating, and it exhibits no gelation ability. Interestingly, DBC is readily soluble in NaOH solution at room temperature and the self-assembled hydrogels are obtained by adjusting the basic DBC aqueous solution with HCl to achieve a given pH value (<3.

MicroRNA-214 Suppresses Ovarian Cancer by Targeting β-Catenin.

Background/aims: Ovarian cancer is one of the most common malignancies with a high rate of mortality in women. However, current therapies for ovarian cancer treatment are ineffective. Therefore, novel target identification is an urgent requisite.

Development of matrix solid-phase dispersion method for the extraction of short-chain chlorinated paraffins in human placenta.

Chlorinated paraffins (SCCPs) are widely used worldwide, and they can be released into the environment during their production, transport, usage and disposal, which pose potential risks for human health. In this work, an efficient, reliable and rapid pretreatment method based on matrix solid-phase dispersion (MSPD) was developed for the analysis of short-chain CPs (SCCPs) in human placenta by gas chromatograph-electron capture negative ion low-resolution mass spectrometry (GC-ECNI-LRMS) and gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOF-HRMS). The MSPD-relevant parameters including dispersing sorbent, sample-to-sorbent mass ratio, and elution solvent were optimized using the orthogonal test.

Self-assembled metallogels formed from N,N',N''-tris(4-pyridyl)trimesic amide in aqueous solution induced by Fe(III)/Fe(II) ions.

In this work, we report self-assembled metallogels formed from a ligand of trimesic amide, N,N',N''-tris(4-pyridyl)trimesic amide (TPTA), induced by Fe(III)/Fe(II) ions. TPTA is difficult to dissolve in water even in the presence of some metal ions such as Cu(2+), Co(2+), Ni(2+), K(+), Na(+) and Mg(2+) under heating, and it exhibits no gelation ability. Interestingly, upon heating TPTA can be dissolved easily in aqueous solution containing Fe(3+)/Fe(2+), and subsequently self-assembled into metallogels after cooling.

Heat-set gels formed from easily accessible gelators of a succinamic acid derivative (SAD) and a primary alkyl amine (R-NH2).

Currently, the design and construction of an intelligent stimuli-responsive gel system is still a significant challenge. We present here a new gel system from which the formation of heat-set gels, conventional gels and irreversible heat-set gels can be achieved in aromatic solvents. This gel system is based on two-component gelators containing a succinamic acid derivative (SAD) and a primary alkyl amine (R-NH2).

Effect of functional group on the monolayer structures of biodegradable quaternary ammonium surfactants.

The monolayer structures and conformational ordering of cationic surfactants including the biodegradable quaternary ammonium molecules have been systematically characterized by π-A isotherm, surface potential, atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and sum frequency generation (SFG) vibrational spectroscopy. It was found that the monolayer of the typical dialkyl dimethylammonium on the water surface was less densely packed along with many conformational gauche defects. The packing density and ordering of these monolayers were improved as halide ions were added to the subphase.

A microporous hydrogen-bonded organic framework: exceptional stability and highly selective adsorption of gas and liquid.

An extremely stable hydrogen-bonded organic framework, HOF-8, was fabricated. HOF-8 is not only thermally stable but also stable in water and common organic solvents. More interestingly, desolvated HOF-8 exhibits high CO2 adsorption as well as highly selective CO2 and C6H6 adsorption at ambient temperature.

Molecular assemblies of 4-(hexadecyloxy)-n-(pyridinylmethylene)anilines at the air-water interface and Cu(II)-promoted vesicle formation via metal coordination.

The molecular assemblies of 4-(hexadecyloxy)-N-(pyridinylmethylene)anilines (HPA) at the air-water interface on pure water and aqueous Cu(II) subphases have been investigated using in situ infrared reflection absorption spectroscopy (IRRAS). The Schiff base units were oriented with their long axes almost perpendicular to the water surface, and both imine and pyridinyl nitrogen atoms of the Schiff base units were coordinated to Cu(II) ions together with their geometrical conversions. The alkyl chains in the monolayers were quantitatively determined on the assumption that the HPA monolayers at the air-water interface were composed of sublayers of alkyl chains and Schiff base units, and the chain orientation angle on pure water was 30 +/- 2 degrees and increased to 37 +/- 2 degrees on the aqueous Cu(II) subphase.

In situ studies of metal coordinations and molecular orientations in monolayers of amino-acid-derived Schiff bases at the air-water interface.

The surface behaviors of monolayers of amino-acid-derived Schiff bases, namely, 4-(4-(hexadecyloxy)benzylideneamino)benzoic acid (HBA), at the air-water interface on pure water and ion-containing subphases (Cu2+, Ca2+, and Ba2+) have been clarified by a combination of surface pressure-area isotherms and surface plasmon resonance (SPR) technique, and the metal coordinations and molecular orientations in the monolayers have been investigated using in situ infrared reflection absorption spectroscopy (IRRAS). The presence of metal ions gives rise to condensation of the monolayers (Cu2+, pH 6.1; Ca2+, pH 11; Ba2+, pH 10), even leading to the formation of three-dimensional structures of the compressed monolayer in the case of Ba2+ (pH 12).

Controllable synthesis of CuS-P(AM-co-MAA) composite microspheres with patterned surface structures.

Copper sulfide-poly(acrylamide-co-methacrylic acid) (CuS-P(AM-co-MAA)) composite microspheres with patterned surface structures have been synthesized in a controllable manner by means of the polymer microgel template method. The formation of CuS particles can be regulated by controlling the decomposition of thioacetamide (TAA) in acidic solution. Compared with the microgel template, the surface morphologies of the composite microspheres are characterized by compact and creased textures.

Determination of chain orientation in the monolayers of amino-acid-derived schiff base at the air-water interface using in situ infrared reflection absorption spectroscopy.

The chain orientation in the monolayers of amino-acid-derived Schiff base, 4-(4-dodecyloxy)-2-hydroxybenzylideneamino)benzoic acid (DSA), at the air-water interface has been determined using infrared reflection absorption spectroscopy (IRRAS). On pure water, a condensed monolayer is formed with the long axes of Schiff base segments almost perpendicular to the water surface. In the presence of metal ions (Ca2+, Co2+, Zn2+, Ni2+, and Cu2+) in the subphase, the monolayer is expanded and the long axes of the Schiff base segments are inclined with respect to the monolayer normal depending on metal ion.

Chain orientation and headgroup structure in Langmuir monolayers of stearic acid and metal stearate (Ag, Co, Zn, and Pb) studied by infrared reflection-absorption spectroscopy.

The monolayers of stearic acid at the air-water interface on pure water and ion-containing subphases have been studied using infrared reflection-absorption spectroscopy. In the presence of Co(2+), Zn(2+), and Pb(2+), ordered hydrocarbon chains and hexagonal subcell structure remain almost unchanged in comparison with those for the monolayer on pure water at the surface pressure of 20 m/Nm. In the cases of Co(2+) and Zn(2+), the H-bonded monodentate and unsymmetric bidentate chelating structure within the headgroups were formed, and in the case of Pb(2+), three types of structures, bidentate chelating, unsymmetric chelating, and bidentate bridging coordinations, were formed.