Publications by authors named "Huijian Fan"
Article Synopsis
- The study compares cancer outcomes for patients with FIGO 2018 stage IIIC cervical cancer treated with three different methods: abdominal radical hysterectomy (ARH), neoadjuvant chemotherapy (NACT), and radical chemoradiotherapy (R-CT).
- Researchers analyzed survival data from 4,086 patients categorized into T1, T2a, T2b, and T3 groups using Kaplan-Meier and Cox regression methods to assess overall survival (OS) and disease-free survival (DFS).
- The results suggest that NACT generally resulted in worse OS and DFS compared to ARH, while R-CT showed comparable outcomes to both ARH and NACT across different tumor
Article Synopsis
- - The study investigated whether surgical patients with stage IB1-IIA2 cervical cancer benefit from having a para-aortic lymphadenectomy (removal of lymph nodes) alongside other surgical procedures.
- - A comparison was made between two groups of patients (8,802 in total) to see if those who had the para-aortic lymphadenectomy experienced better survival rates than those who did not.
- - Findings showed no significant difference in 5-year survival outcomes regardless of whether para-aortic lymphadenectomy was performed, suggesting that it isn't recommended, particularly for patients without pelvic lymph node metastasis.
Purpose: Radiomic models have been demonstrated to have acceptable discrimination capability for detecting lymph node metastasis (LNM). We aimed to develop a computed tomography-based radiomic model and validate its usefulness in the prediction of normal-sized LNM at node level in cervical cancer.
Methods: A total of 273 LNs of 219 patients from 10 centers were evaluated in this study.
Article Synopsis
- The study compares the 5-year overall survival (OS) and disease-free survival (DFS) rates of laparoscopic radical hysterectomy (LRH) versus abdominal radical hysterectomy (ARH) in patients with stage IIA1 cervical squamous cell carcinoma.
- After analyzing data from a large database, results show that LRH has similar 5-year OS but significantly lower DFS compared to ARH, particularly in patients with tumors sized 2 cm or greater.
- The findings suggest that while LRH may be safe for smaller tumors, it is associated with poorer outcomes in terms of DFS in larger tumors, highlighting the necessity for careful surgical approach selection based on tumor size.
Objective: To determine the associations between the presence and depth of uterine corpus invasion and survival in patients with cervical cancer.
Methods: Clinical data of patients with stage IA2-IIB cervical cancer who underwent radical hysterectomy between 2004 and 2016 were retrospectively reviewed. Uterine corpus invasion was identified from a review of uterine pathology.
To investigate whether pre-treatment CT-derived radiomic features could be applied for prediction of clinical response to neoadjuvant chemotherapy (NACT) in locally advanced cervical cancer (LACC). Two hundred and seventy-seven LACC patients treated with NACT followed by surgery/radiotherapy were included in this multi-institution retrospective study. One thousand and ninety-four radiomic features were extracted from venous contrast enhanced and non-enhanced CT imaging for each patient.
View Article and Find Full Text PDFObjective: To build and validate a CT radiomic model for pre-operatively predicting lymph node metastasis in early cervical carcinoma.
Methods And Materials: A data set of 150 patients with Stage IB1 to IIA2 cervical carcinoma was retrospectively collected from the Nanfang hospital and separated into a training cohort ( = 104) and test cohort ( = 46). A total of 348 radiomic features were extracted from the delay phase of CT images.
Objective: To present the distribution of neurovascular and lymphatic vessels in uterine ligaments using 3D models based on the pathological staining of serial 2D sections of postoperative specimens.
Methods: Serial transverse sections of fresh uterine ligaments from a patient with stage IB1 cervical squamous cell carcinoma were studied using the computer-assisted anatomic dissection (CAAD) technique. The sections were stained with hematoxylin and eosin, Weigert elastic fibers, D2-40 and immunostainings (sheep anti-tyrosine hydroxylase and rabbit anti-vasoactive intestinal peptide).