Publications by authors named "Huijia Guo"
Highly efficient silencing of microRNA by heteroduplex oligonucleotides.
Nucleic Acids Res
August 2019
Article Synopsis
- - AntimiR is an antisense oligonucleotide aimed at silencing microRNA (miRNA) to treat hard-to-manage diseases, but improving its effectiveness and reducing toxicity has been a challenge.
- - Researchers developed a new technology called heteroduplex oligonucleotide (HDO)-antimiR, which binds more effectively to targeted miRNA in living organisms, showing a 12-fold increase in efficiency compared to traditional single-stranded antimiR.
- - The study found that HDO-antimiR enhanced the expression of messenger RNAs that target miRNA, indicating its greater potency is due to improved intracellular effects rather than better stability or delivery to cells.