A Universal Method for Fingerprinting Multiplexed Bacteria: Evolving Pruned Sensor Arrays via Machine Learning-Driven Combinatorial Group-Specificity Strategy.

Array-based sensing technology holds immense potential for discerning the intricacies of biological systems. Nevertheless, developing a universal strategy for simultaneous identification of diverse types of multianalytes and meeting the diagnostic needs of a range of multiclassified clinical diseases poses substantial challenges. Herein, we introduce a combination method for constructing sensor arrays by assembling two types of group-specific elements.

A Supramolecular Fluorescent Sensor Array Composed of Conjugated Fluorophores and Cucurbit[7]uril for Bacterial Recognition.

Bacterial infections have emerged as a significant contributor to global mortality and morbidity rates. Herein, we introduce a dual fluorescence "turn-on" supramolecular sensor array composed of three assembled complexes (-), formed from three positively charged fluorophores (-) and one cucurbit[7]uril (CB[7]). The ability of this three-element array to simultaneously recognize 10 bacterial species within just 30 s was remarkable, boasting an impressive 100% accuracy.

Digital pH fluorescent sensing shown by small organic molecules.

A series of 2-(N-oxide pyridyl)-5-methoxythiazoles were synthesized and corresponding optical properties were also investigated. It is first found that a digital-type fluorescent responses in a sharp pH variation with dual-emission could be fulfilled based on a small fluorophore.