White matter impairments in autism, evidence from voxel-based morphometry and diffusion tensor imaging.

This study explored white matter abnormalities in a group of Chinese children with high functioning autism (HFA). Twelve male children with HFA and ten matched typically developing children underwent diffusion tensor imaging (DTI) as well three-dimensional T1-weighted MRI for voxel-based morphometry (VBM). We found a significant decrease of the white matter density in the right frontal lobe, left parietal lobe and right anterior cingulate and a significant increase in the right frontal lobe, left parietal lobe and left cingulate gyrus in the HFA group compared with the control group.

Voxel-based morphometry study on brain structure in children with high-functioning autism.

Earlier studies have suggested abnormal brain volumes in autism, but inconsistencies exist. Using voxel-based morphometry, we compared global and regional brain volumes in 17 high-functioning autistic children with 15 matched controls. We identified significant reduction in left white matter volume and white/gray matter ratio in autism.