Publications by authors named "Huigeng Zhu"
MicroRNAs (miRNAs) are involved in many pathological and biological processes, such as ischemia/reperfusion (I/R) injury by modulating gene expression. Increasing evidence indicates that miR-378a-3p might provide a potential cardioprotective effect against ischemic heart disease. Cell apoptosis is a crucial mechanism in I/R injury.
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- FAM46C is linked to sepsis-induced myocardial dysfunction (SIMD), which is critical in predicting sepsis outcomes.
- The study found that FAM46C can reduce cell apoptosis caused by lipopolysaccharides (LPS) in cardiac cells, with its effect mediated through specific signaling pathways.
- This research highlights the potential of FAM46C as a therapeutic target to mitigate myocardial dysfunction in sepsis, marking the first exploration of its role in SIMD.