Publications by authors named "Huige Guo"

Article Synopsis
  • Heart disease (HD) encompasses various heart-related diseases, and research indicates that mitochondrial dysfunction plays a key role in its development.
  • The protein PGC‑1α is crucial for maintaining mitochondrial function by influencing energy metabolism, biogenesis, and response to oxidative stress, and its activity is modulated by multiple signaling pathways.
  • The review also discusses the involvement of PGC‑1α in several HD conditions, such as heart failure and diabetic cardiomyopathy, highlighting the complexity of its therapeutic role and the challenges in targeting it for treatment.
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Prevalent interactions among marine phytoplankton triggered by long-range climatic stressors are well-known environmental disturbers of community structure. Dynamic response of phytoplankton physiology is likely to come from interspecies interactions rather than direct climatic effect on single species. However, studies on enigmatic interactions among interspecies, which are induced by bioactive extracellular compounds (BECs), especially between related harmful algae sharing similar shellfish toxins, are scarce.

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Microplastics (MPs) have drawn exponential attention as anthropogenic pollutants, which have invaded every corner of planet. Seamounts are prominent features of the deep-sea topography, acting as breeding ground for marine animal calves and hotspots of pelagic biodiversity, yet MPs pollution in seamounts is scarcely studied. We investigated the MPs load in the whole vertical profile of seamount ambient water in the Subtropical Northwest Pacific Ocean.

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Mercury (Hg) isotopes provide a useful tool to understand Hg sources and processes in the environment. The Hg isotopic composition of seawater remains poorly constrained due to the lack of an efficient method to process large volumes of low-Hg-concentration seawater samples. Here, we develop a continuous flowdouble purge and trap device for the in situ preconcentration of Hg in seawater.

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Epidemiological studies in recent years have identified an association between exposure to air pollutants and acute myocardial infarction (AMI); however, the association between short-term ozone (O) exposure and AMI hospitalization remains unclear, particularly in developing countries. Therefore, this study collected information on 24,489 AMI patients, including daily air pollutant and meteorological data in Henan, China, between 2016 and 2021. A distributed lagged nonlinear model combined with a Poisson regression model was used to estimate the nonlinear lagged effect of O on AMI hospitalizations.

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Enhancer of zeste homolog 2 (EZH2) is a catalytic subunit of polycomb repressor complex 2 and plays important roles in endothelial cell homeostasis. EZH2 functionally methylates lysine 27 of histone H3 and represses gene expression through chromatin compaction. EZH2 mediates the effects of environmental stimuli by regulating endothelial functions, such as angiogenesis, endothelial barrier integrity, inflammatory signaling, and endothelial mesenchymal transition.

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A simple resorcinol method to determine nitrate (NO) in seawater using a microplate reader with a 48-well plate was established. The method involved the nitration of resorcinol in sulfuric acid to form a pink product that was detected at 505 nm. Reagent concentrations were optimized, and the effect of salinity on NO determination was investigated.

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Multi-wavelength radiometric thermometry has a wide application prospect in many fields. However, due to unknown emissivity, the data processing algorithm remains a difficult problem. The Broyden-Fletcher-Goldfarb-Shanno (BFGS) algorithm is proposed to inverse true temperature and spectral emissivity without assuming the emissivity model.

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Pharmaceuticals and personal care products (PPCPs) in the sea area surrounding a densely populated tourist city in southeastern China were investigated. In total, 32 PPCP pollutants classified into 23 categories were detected. Different spatial distribution patterns of PPCPs indicated possible contamination from runoff and multiple local sources.

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China is the largest plastic consumer in the world. Despite its plastic waste import ban in 2017, this populous economy inevitably generates a large amount of waste, including plastic waste, a considerable part of which has become marine litter. Data from the 2018 National Coastal Cleanup and Monitoring Project, the largest beach litter monitoring activities using the citizen science approach in China, have been retrieved and analyzed to understand spatial patterns, composition, and original usage of marine litter.

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Marine debris characterization is fundamental for developing policies aiming at ending the flow of marine debris at the source. China has the largest coastal population in the world. For this emerging economy, the sources of debris might be different from those in regions at different developmental stages.

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People are increasingly aware of ubiquitous microplastic (MP) pollution in the world's ocean due to its far-reaching harmful impacts on marine ecosystem and potential hazards to human health, yet surprisingly comparatively limited studies about the abundance, source, transport, and fate of MPs in the Northwestern Pacific Ocean are available. We conducted the field survey of MPs pollution at the surface of the Northwestern Pacific Ocean between August 25 and September 26, 2017. MPs were collected from 18 sampling stations in the Northwestern Pacific Ocean using a manta trawl net with a mesh size of ∼330 μm and a rectangular net opening of 0.

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Prevalence of microplastics (MPs) throughout the world's oceans has raised growing concerns due to its detrimental effects on the environment and living organisms. Most recent studies of MPs, however, have focused on the estuaries and coastal regions. There is a lack of study of MPs pollution in the open ocean.

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