Regulating the aromatic structure in carbon dots to enhance the internal filter effect for sensitive on-site monitoring of anthrax biomarkers.

Anthrax, a fatal infectious disease caused by Bacillus anthracis (B. anthracis), poses a significant threat to public health. Herein, a novel type of carbon dots rich in π → π∗ transitions (R-CDs) was developed to fabricate an R-CDs/Eu hybrid for the rapid on-site detection of the B.

Transformative insights in breast cancer: review of atomic force microscopy applications.

Breast cancer remains one of the foremost global health concerns, highlighting the urgent need for innovative diagnostic and therapeutic strategies. Traditional imaging techniques, such as mammography and ultrasound, play essential roles in clinical practice; however, they often fall short in detecting early-stage tumors and providing comprehensive insights into the mechanical properties of cancer cells. In this context, Atomic Force Microscopy (AFM) has emerged as a transformative tool in breast cancer research, owing to its high-resolution imaging capabilities and nanomechanical characterization.

Case Report: Necrotizing pneumonia in pediatric patients: a rare case of unilateral necrosis in two entire lobe tissues.

Background: Necrotizing pneumonia is a serious complication of infection, especially in pediatric patients. Although necrotizing pneumonia is a rare condition, the occurrence of unilateral necrosis in two entire lobe tissues is even rarer. This case study presents a 5-year-old male child with necrotizing pneumonia caused by , describing the clinical features, laboratory abnormalities, and radiographic findings associated with this condition, particularly the rare occurrence of unilateral necrosis in two entire lobe tissues.

Acute Concurrent Exercise Improves Inhibitory Control Without Mediating the Role of Lactate: An Event-Related Potential Study.

Background: Concurrent exercise (CE), an emerging exercise modality characterized by sequential bouts of aerobic (AE) and resistance exercise (RE), has demonstrated acute benefits on executive functions (EFs) and neuroelectric P3 amplitude. However, the effect of acute CE on inhibitory control, a sub-component of EFs, and P3 amplitude remains inconclusive. Moreover, exploring the mechanisms underlying the effects of acute exercise on EFs contributes to scientific comprehension, with lactate recognized as a crucial candidate positively correlated with EFs.

Microcystin-LR Exposure Damages Neurons by Inducing α-Syn Aggregation via MAPK4/GATA2/SNCA and PP2A/GRKs Pathways.

Microcystin-LR (MC-LR) is a natural neurotoxin with strong toxicity, and studies have demonstrated that chronic MC-LR exposure generated Parkinson-like dyskinesia in mice. Parkinson's disease (PD) is a neurologic degenerative disease mostly occurring in elderly people, and the progressive loss of dopaminergic neurons and the formation of Lewy bodies are the hallmark pathological features. The main component of Lewy bodies is α-synuclein (α-syn) encoded by the SNCA gene, and the copy number mutation of SNCA gene can promote the overexpression of α-syn.

Enhanced NH-SCR activity of Cu-SAPO-34 by regulating Si distribution an interzeolite conversion strategy.

An interzeolite conversion (IZC) method was developed for the rapid synthesis of Cu-SAPO-34 from SAPO-37, achieving isolated Si distribution and optimized Cu states. The resulting Cu-SAPO-34 exhibited exceptional NH-SCR performance, with over 90% NO conversion from 200-600 °C due to proper acidity and Cu status generated from the isolated Si.

Screening, identification and functional validation of Microcystin-LR direct binding target proteins based on thermal proteomics profiling.

Microcystin-LR (MC-LR) is one of the most common harmful cyanobacterial toxin and poses a serious threat to human health and ecosystems. The accepted toxic effect of MC-LR is to inhibit its enzymatic activity by covalently binding to protein phosphatase 2A (PP2A). However, numerous researches have revealed that the toxic effects of MC-LR are not solely dependent on PP2A.

Supportive care needs of parents caring for children with leukemia: a latent profile analysis.

Background: Parents' supportive care needs directly affect their quality of life and the quality of care for their children diagnosed with leukemia.

Objectives: To identify supportive care needs of Chinese parents in the unobserved subgroups who care for children with leukemia and to examine the associations of the latent class membership with individual characteristics.

Methods: A multicenter cross-sectional survey study was conducted.

Identifying Typologies of Symptoms and Functional Impairments in Chinese Children With Leukemia and Their Population Characteristics: A Latent Profile Analysis.

Background: Symptom distress and functional impairments in children with leukemia directly affect their quality of life.

Objectives: To identify subgroups of symptom distress and functional impairments in Chinese children with leukemia and to examine the associations of the latent classes with individual characteristics.

Methods: This multicenter cross-sectional survey study recruited children with leukemia who received chemotherapy in 4 hospitals in Shanghai, Jiangsu, Zhejiang, and Guangdong Province.

MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2.

Microcystins are environmental toxins produced by freshwater cyanobacteria. Microcystin-LR (MC-LR) is one of the most abundant and harmful isomers. MC-LR poses a serious threat to human health.

Preparation of composite calcium phosphate cement scaffold loaded with Hedysarum polysaccharides and its efficacy in repairing bone defects.

It's imperative to create a more ideal biological scaffold for bone defect repair. Calcium phosphate bone cements (CPC) could be used as a scaffold. Some ingredients and osteogenic factors could be added to improve its poor mechanical properties and biological activity.

Insights to the cooperation of double-working potential electroactive biofilm for performance of sulfamethoxazole removal: ARG fate and microorganism communities.

Bioelectrochemical systems (BESs) have shown great potential in enhancing sulfamethoxazole (SMX) removal. However, electroactive biofilms (EBs) constructed with single potentials struggle due to limited biocatalytic activity, hindering deep SMX degradation. Here, we constructed a double-working potential BES (BES-D) to investigate its ability to eliminate SMX and reduce the levels of corresponding antibiotic resistance genes (ARGs).

Enhancing Stability of SAPO-37 Molecular Sieve through Aluminum Phosphate Utilization: Synthesis, Stability Mechanism, and Catalytic Performance.

SAPO-37 molecular sieve, characterized by its three-dimensional 12-membered-ring FAU structure, has drawn wide attention due to its unique properties and catalytic potential. However, its susceptibility to framework collapse under low-temperature and humid conditions hinders practical applications, affecting both the reaction performance and sample storage. To tackle this, we utilized aluminum phosphate as a precursor for synthesizing SAPO-37, aiming to modify Si incorporation mechanisms and improve P and Al environments.

Basement membrane-associated gene expression as a predictor of survival in oral cancer.

Background: This study sought to investigate the prognostic value of basement membrane (BM)-associated gene expressions in oral cancer.

Methods: We harvested and integrated data on BM-associated genes (BMGs), the oral cancer transcriptome, and clinical information from public repositories. After identifying differentially expressed BMGs, we used Cox and Lasso regression analyses to create a BMG-based risk score for overall survival at various intervals.

pH-responsive dual-emission carbon dots for the ratiometric detection of organophosphorus pesticides in Brassica chinensis and Hg in water.

Accurate and rapid monitoring of organophosphorus pesticides (OPs) residues is crucial for regulating food safety. Herein, dual-emission carbon dots (de-CDs) were fabricated for the ratiometric detection of OPs and Hg. The de-CDs exhibited two emission peaks at 678 and 485 nm when excited with visible light.

Synthetic Microbial Community Members Interact to Metabolize Caproic Acid to Inhibit Potato Dry Rot Disease.

The potato dry rot disease caused by spp. seriously reduces potato yield and threatens human health. However, potential biocontrol agents cannot guarantee the stability and activity of biocontrol.

Fabrication of a ZIF-on-lamella-zeolite architecture as a highly efficient catalyst for aldol condensation.

Designing composite catalysts that harness the strengths of individual components while mitigating their limitations is a fascinating yet challenging task in catalyst engineering. In this study, we aimed to enhance the catalytic performance by anchoring ZIF-67 nanoparticles of precise sizes onto lamella Si-MWW zeolite surfaces through a stepwise regrowth process. Co ions were initially grafted onto the zeolite surface using ultrasonication, followed by a seed-assisted secondary growth method.

Correlation of serum complement factor 5a level with inflammatory response and cognitive function in patients with Alzheimer's disease of different severity.

Background: Alzheimer's disease (AD) is a common cause of dementia. Serum complement factor 5a (C5a) is exceedingly implicated in AD. We explored the role of C5a levels in AD patients of different severity.

Aggregation-induced emission enhancement of gold nanoclusters triggered by sodium heparin and its application in the detection of sodium heparin and alkaline amino acids.

This work first reported that sodium heparin could cause the aggregation-induced emission enhancement (AIEE) effect of GSH-AuNCs (Glutathione functionalized gold nanoclusters). While it was interestingly found that the addition of alkaline amino acids would greatly weaken this effect. Thus, fluorescent system was designed for the quantitative detection of sodium heparin and alkaline amino acids.

Seed-Assisted Interzeolite Conversion Strategy for Fabricating Lewis Acid Sn-CHA Zeolites.

Small-pore Lewis acid zeolites have been showing increasing potential in shape-selective reactions regarding small-molecule conversion. In this study, Sn-CHA with tunable framework Sn contents was facilely prepared via a fluoride-free, seed-assisted interzeolite conversion (IZC) pathway. Commercially available dealuminated USY functioned as the parent sample, and seeding played a vital role in accelerating the transformation process, promoting the target zeolite yield, and guiding the attached-growth pathway.

Enhanced removal of antibiotic and antibiotic resistance genes by coupling biofilm electrode reactor and manganese ore substrate up-flow microbial fuel cell constructed wetland system.

Manganese ore substrate up-flow microbial fuel cell constructed wetland (UCW-MFC(Mn)) as an innovative wastewater treatment technology for purifying antibiotics and electricity generation with few antibiotic resistance genes (ARGs) generation has attracted attention. However, antibiotic purifying effects should be further enhanced. In this study, a biofilm electrode reactor (BER) that needs direct current driving was powered by a Mn ore anode (UCW-MFC(Mn)) to form a coupled system without requiring direct-current source.

KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma.

Cell division cycle associated 5 (CDCA5) is correlated with the development and progression of many malignant tumors. However, little is known about its role in epithelial ovarian cancer (EOC) progression. In this study, the clinical value, biological function and underlying mechanisms of CDCA5 in EOC were evaluated.