Effect of dehydroepiandrosterone administration before in vitro fertilization on the live birth rate in poor ovarian responders according to the Bologna criteria: A randomised controlled trial.

Objective: To evaluate the effect of dehydroepiandrosterone (DHEA) pre-treatment before in vitro fertilization and embryo transfer (IVF-ET) on the live birth rate in infertile women with poor ovarian response (POR) defined according to the Bologna criteria.

Design: A randomized, double-blind, placebo-controlled trial.

Setting: Nine reproductive medical centers in China.

Two New Types of Homodiploid Fish and Polyploid Hybrids Derived from the Distant Hybridization of Female Koi Carp and Male Bighead Carp.

Bighead carps  (Hypophthalmichthys nobilis) and silver carps (Hypophthalmichthys molitrix) represent an important component of freshwater ichthiofauna in its native range, though they might become mass propagation in other systems (North America) and the reason of concern for fisheries management. Therefore, understanding their reproductive traits and particularly in the context of hybridization with other cyprinids was of value to explain their rapid propagation as well as potential benefits for aquaculture due to their unique diet, behavior, growth potential, and tolerance to deteriorating environmental conditions in freshwater ecosystems. Distant hybridization is an effective tool to create different ploidy offspring with changed phenotypes and genotypes.

Variations in the Mitochondrial Genome of a Goldfish-Like Hybrid [Koi Carp (♀) × Blunt Snout Bream (♂)] Indicate Paternal Leakage.

Previously, a homodiploid goldfish-like fish (2 = 100; GF-L) was spontaneously generated by self-crossing a homodiploid red crucian carp-like fish (2 = 100; RCC-L), which was in turn produced via the distant hybridization of female koi carp (, KOC, 2 = 100) and male blunt snout bream (, BSB, 2 = 48). The phenotypes and genotypes of RCC-L and GF-L differed from those of the parental species but were similar to diploid red crucian carp (2 = 100; RCC) and goldfish (2 = 100; GF), respectively. We sequenced the complete mitochondrial DNAs (mtDNAs) of the KOC, BSB, RCC-L, GF-L, and subsequent generations produced by self-crossing [the self-mating offspring of RCC-L (RCC-L-F) to the self-mating offspring of RCC-L-F (RCC-L-F) and the self-mating offspring of GF-L (GF-L-F)].

The Hybrid Genome of a New Goldfish-Like Fish Lineage Provides Insights Into the Origin of the Goldfish.

Distant hybridization leads to obvious changes in genotypes and phenotypes, giving rise to species with novel capabilities. However, the fusion of distinct genomes also polymerizes the DNA or gene variations that occur during the course of evolution. Knowledge of the early stages of post-hybridization evolution is particularly important.

Hox genes reveal variations in the genomic DNA of allotetraploid hybrids derived from Carassius auratus red var. (female) × Cyprinus carpio L. (male).

Background: Hox transcription factors are master regulators of animal development. Although highly conserved, they can contribute to the formation of novel biological characteristics when modified, such as during the generation of hybrid species, thus potentially serving as species-specific molecular markers. Here, we systematically studied the evolution of genomic sequences of Hox loci in an artificial allotetraploid lineage (4nAT, 4n = 200) derived from a red crucian carp (♀, RCC, 2n = 100) × common carp (♂, CC, 2n = 100) cross and its parents (RCC and CC).

Krüppel-like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway.

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The most important reason for the occurrence of HCC is hepatitis C or B infection. Moreover, genetic factors play an important role in the tumorigenesis of HCC.

Use of Walnut Shell Powder to Inhibit Expression of Fe(2+)-Oxidizing Genes of Acidithiobacillus Ferrooxidans.

Acidithiobacillus ferrooxidans is a Gram-negative bacterium that obtains energy by oxidizing Fe(2+) or reduced sulfur compounds. This bacterium contributes to the formation of acid mine drainage (AMD). This study determined whether walnut shell powder inhibits the growth of A.

[Observation of the efficacy of allergen blocking nasal spray in patients with rhinitis sicca].

Objective: To observe the efficacy of allergen blocking nasal spray (ABNS) , combined with seawater spray (SS) and myrtol standardized capsules (MSS), in patients with rhinitis sicca.

Method: Patients diagnosed as rhinitis sicca were randomly divided into 2 groups: ABNS+SS group and SS group. In ABNS+SS group, patients used ABNS and SS four times per day and MSS twice per day.

[Health economics analysis of specific immunotherapy in allergic rhinitis accompanied with asthma].

Objective: To investigate the cost-effectiveness of standardized specific immunotherapy (SIT) for allergic rhinitis patients accompanied with asthma (ARAS) in China.

Method: Forty ARAS patients sensitized with house dust mite (HDM) were administered with SIT (SIT group) or merely medicine treatment (control group). Alutard dermatophagoides pteronyssinus vaccine from ALK company was used for immunotherapy.

[Efficacy evaluation of specific immunotherapy with standardized dermatophagoides pteronyssinus extract for allergic rhinitis accompanied with asthma].

Objective: To evaluate the efficacy of specific immunotherapy (SIT) with standardized dermatophagoides pteronyssinus extract for allergic rhinitis (AR)accompanied with asthma.

Method: One hundred and fifty-five patients (40 AR with asthma, AR & asthma) in accordance with the inclusion criteria of SIT, were allocated to receive standardized Dermatophagoides pteronyssinus extract (SIT group, n = 89) or medical treatment (control group, n = 66). AR with or without asthma was observed separately.

[Age features of the allergens in allergic rhinitis patients of different age in Hubei area].

Objective: To investigate the distribution of positive allergens in patients with allergic rhinitis and the discrepancy among different age group.

Method: Skin prick tests were done to 2 808 allergic rhinitis patients, the major allergens of local area were tested with standard allergens. Data was analyzed with age and allergens.

[Efficacy evaluation of polysaccharide nucleic acid-fraction of BCG on vasomotor rhinitis].

Objective: To investigate the efficacy and safety of polysaccharide nucleic acid-fraction (BCG-PSN) in the treatment of vasomotor rhinitis.

Method: Sixty patients were randomly divided into BCG-PSN group (n = 30) and control group (n = 30). The patients in BCG-PSN group were administered with BCG-PSN 1.

[The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis].

Objective: To study the role of serum IL-10, 12, 13, 16 in patients with allergic rhinitis and vasomotor rhinitis.

Method: The serum levels of IL-10, 12, 13, 16 were measured by ELISA in 30 cases of allergic rhinitis, 25 cases of vasomotor rhinitis and 20 healthy people.

Result: The level of IL-12 in allergic rhinitis was (170.

[Safety analysis of Allergovit immunotherapy in patients of allergic rhinitis].

Objective: To analyse the safety of Allergovit immunotherapy in patients of allergic rhinitis.

Method: Two hundred and fifty-six patients with allergic rhinitis received Allergovit immunotherapy, their local and systemic side-effect were observed, recorded and analyzed during the treatment.

Result: The number of patients who got local side-effect was 84 cases, the percent of local side-effect was 4.

[Choice of the methods for inferior turbinectomy].

Objective: To make clear the indications for each kind of inferior turbinectomy and to find out the best way of inferior turbinectomy.

Method: The nasal resistances in pre-operation and post-operation were examined with rhinomanometer in 97 cases. The time of recovery, the symptoms remained and the complications after operation were recorded.

[The study of the relationship between obstructive sleep apnea syndrome and positional nasal resistance].

Objective: To study the nasal resistance in different position and its possible relationship to obstructive sleep apnea syndrome (OSAS).

Method: The positional rhinomanometry and the detection of polysomnography were performed in 14 normal subjects, 20 snoring patients and 40 patients with OSAS.

Result: The study reveals that: 1.