HOXA cluster antisense RNA 2 elevates KIAA1522 expression through microRNA-520d-3p and insulin like growth factor 2 mRNA binding protein 3 to promote the growth of vascular smooth muscle cells in thoracic aortic aneurysm.

Aims: Recently, long non-coding RNAs (lncRNAs) have been revealed to mediate smooth muscle dysfunction in thoracic aortic aneurysm (TAA). LncRNA HOXA-AS2 has been proposed to engage in the regulation of diverse diseases. However, its function in TAA remains unknown.

Polyunsaturated Fatty Acid Diet and Upregulation of Lipoxin A4 Reduce the Inflammatory Response of Preeclampsia.

The aim of this study was to investigate the effects and mechanisms of polyunsaturated fatty acids (PUFAs) and lipoxin A4 (LXA4) on preeclampsia (PE). The LXA4 level was significantly reduced in PE rats. The PUFA diet upregulated the expressions of lipoxygenase 12 (LOX12) and lipoxygenase 15 (LOX15) and downregulated those of cyclooxygenase-2, tumor necrosis factor-α (TNF-α), and endoglin.

METTL3 promotes the proliferation and invasion of esophageal cancer cells partly through AKT signaling pathway.

Methyltransferase-like 3 (METTL3) is identified as a methyltransferase responsible for N-methyladenosine (mA) modification of mRNA, miRNA and lncRNA. Emerging evidences suggest that METTL3 is involved in tumorigenesis and progression of multiple tumor types. However, the functional role of METTL3 in esophageal cancer (EC) remains unclear.

Long noncoding RNA MALAT1 contributes to pregnancy-induced hypertension development by enhancing oxidative stress and inflammation through the regulation of the miR-150-5p/ET-1 axis.

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been identified previously in the pathogenesis of hypertension and some gestational diseases. However, the biological functions of MALAT1 in pregnancy-induced hypertension (PIH) are still poorly understood. Herein, we aim to explore the functional relevance of MALAT1 in PIH and to explain the potential underlying mechanisms.

Complete mitochondrial genome of the Chinese skipper, Polytremis jigongi (Lepidoptera: Hesperiidae).

The sequence of the mitochondrial genome (mitogenome) of Polytremis jigongi (Lepidoptera: Hesperiidae) has been presented in this article. It is 15,353 bp in length, with an A + T content of 80.9% containing 13 protein-coding genes, 22 tRNAs, 2 rRNAs, and a noncoding control region (D-loop).

Complete mitochondrial DNA genome of Polytremis nascens (Lepidoptera: Hesperiidae).

In this study, the complete mitochondrial DNA (mtDNA) sequence of Polytremis nascens (Lepidoptera: Hesperiidae) was determined. The 15,392 bp mitogenome with GenBank accession number KM981865 contained 13 protein genes, 22 tRNAs, 2 rRNAs, and a non-coding control region (D-loop). All the 37 typical animal mitochondrial genes were found.

[Determination of chyodeoxycholic acid in Bile Arisaema by HPLC-ELSD].

Objective: To develop an HPLC method for the determination of hyodeoxycholic acid in Bile Arisaema.

Method: The methanol extracts were separated on a Diamonsil ODS column eluted at 35 degrees C with a mixture of methanol-water-glacial acetic acid (75:25:0.01) at flow-rate 1.

[Quantititive study for chromatographic fingerprints of processed products of Paeonia lactiflora].

Objective: To explore the utility of Principal Factor Analysis (PFA) in chromatographic data for quality control.

Method: Chromatographic fingerprints of processed root pieces of Paeonia lactiflora were determined by HPLC, the PFA was used for data processing.

Result: The quantitative differences among different growing areas and different processing batches were found with the method.

[Experimental study on processing of Paeonia lactiflora].

Objective: To provide experimental data for the quality control of processed Paeonia lactiflora, a Chinese herbal medicine.

Method: Traditional processing of P. lactiflora was simulated, content of paeoniflorin and water extracts among different preparations were assayed by HPLC; The quantitative correlations among different processing conditions were analyzed, the effects of processing parameters on the contents of paeoniflorin and water extracts were assayed a nanalysed.

[Study on quality control of Paeonia lactiflora].

Objective: To provide the experimental data for the quality control of Paeonia lactiflora a prepared Chinese medicinal herb.

Method: The contents paeoniflorin among different growing areas and different processing methods methods were assayed by HPLC.

Result: The quantitative differences of paeoniflorin content among different growing areas and different processing methods wereanalyzed quantitatively.