Nordcan.R: a new tool for federated analysis and quality assurance of cancer registry data.

Aim Of The Article: We present our new GDPR-compliant federated analysis programme (nordcan.R), how it is used to compute statistics for the Nordic cancer statistics web platform NORDCAN, and demonstrate that it works also with non-Nordic data.

Materials And Methods: We chose R and Stata programming languages for writing nordcan.

Association of modifiable lifestyle with colorectal cancer incidence and mortality according to metabolic status: prospective cohort study.

Background: Metabolic syndrome has been linked to an increased risk of colorectal cancer (CRC) incidence and mortality, but whether adopting a healthy lifestyle could attenuate the risk of CRC conferred by metabolic syndrome remains unclear. The aim of the study is to investigate the individual and joint effects of modifiable healthy lifestyle and metabolic health status on CRC incidence and mortality in the UK population.

Methods: This prospective study included 328,236 individuals from the UK Biobank.

Climate change affected the spatio-temporal occurrence of disasters in China over the past five centuries.

Climate change may contribute to the spatio-temporal occurrence of disasters. Long-term studies of either homogeneous or heterogeneous responses of historical disasters to climate change are, however, limited by the quality and quantity of the available proxy data. Here we reconstruct spatio-temporal patterns of five types of disasters in China during the period AD 1368-1911.

Quantitative-Profiling Method of Serum Steroid Hormones by Hydroxylamine-Derivatization HPLC-MS.

A sensitive and rapid high performance liquid chromatography-mass spectrometry (HPLC-MS) method was developed and validated for simultaneous quantification of ten steroid hormones, including estrogens, androgens, progesterones, and corticosteroids four classes of steroids. The following ten steroid hormones were analyzed: progesterone, 21-deoxycortisol, estrone, 4-androstenedione, testosterone, dihydro-testosterone, androstenone, dehydroepiandrosterone, corticosterone and cortisone. Stable deuterated isotopes were used as internal standards for quantification.

Theory of Mind Development in School-Aged Left-Behind Children in Rural China.

The current study aimed to investigate differences in theory of mind between left-behind children and non-left-behind children in rural China and to examine the potential protective role of general reasoning ability in left-behind children's theory of mind. Participants included 213 children aged 7.10-13.

Scale-dependent climatic drivers of human epidemics in ancient China.

A wide range of climate change-induced effects have been implicated in the prevalence of infectious diseases. Disentangling causes and consequences, however, remains particularly challenging at historical time scales, for which the quality and quantity of most of the available natural proxy archives and written documentary sources often decline. Here, we reconstruct the spatiotemporal occurrence patterns of human epidemics for large parts of China and most of the last two millennia.

Spatio-temporal dynamics of a fish predator: Density-dependent and hydrographic effects on Baltic Sea cod population.

Understanding the mechanisms of spatial population dynamics is crucial for the successful management of exploited species and ecosystems. However, the underlying mechanisms of spatial distribution are generally complex due to the concurrent forcing of both density-dependent species interactions and density-independent environmental factors. Despite the high economic value and central ecological importance of cod in the Baltic Sea, the drivers of its spatio-temporal population dynamics have not been analytically investigated so far.

Was mandatory quarantine necessary in China for controlling the 2009 H1N1 pandemic?

The Chinese government enforced mandatory quarantine for 60 days (from 10 May to 8 July 2009) as a preventative strategy to control the spread of the 2009 H1N1 pandemic. Such a prevention strategy was stricter than other non-pharmaceutical interventions that were carried out in many other countries. We evaluated the effectiveness of the mandatory quarantine and provide suggestions for interventions against possible future influenza pandemics.

Validation of the gravity model in predicting the global spread of influenza.

The gravity model is often used in predicting the spread of influenza. We use the data of influenza A (H1N1) to check the model's performance and validation, in order to determine the scope of its application. In this article, we proposed to model the pattern of global spread of the virus via a few important socio-economic indicators.

Reconstruction of a 1,910-y-long locust series reveals consistent associations with climate fluctuations in China.

It is becoming increasingly clear that global warming is taking place; however, its long-term effects on biological populations are largely unknown due to lack of long-term data. Here, we reconstructed a 1,910-y-long time series of outbreaks of Oriental migratory locusts (Locusta migratoria manilensis) in China, on the basis of information extracted from >8,000 historical documents. First by analyzing the most recent period with the best data quality using generalized additive models, we found statistically significant associations between the reconstructed locust abundance and indexes of precipitation and temperature at both annual (A.

Climate change induced range shifts of Galliformes in China.

Climate change will cause range shifts of many species in the future. Galliformes might be particularly vulnerable to climate change, as they have low dispersal ability. Little is known about their possible responses to the future climate.

Periodic climate cooling enhanced natural disasters and wars in China during AD 10-1900.

Recent studies have linked climatic and social instabilities in ancient China; the underlying causal mechanisms have, however, often not been quantitatively assessed. Here, using historical records and palaeoclimatic reconstructions during AD 10-1900, we demonstrate that war frequency, price of rice, locust plague, drought frequency, flood frequency and temperature in China show two predominant periodic bands around 160 and 320 years where they interact significantly with each other. Temperature cooling shows direct positive association with the frequency of external aggression war to the Chinese dynasties mostly from the northern pastoral nomadic societies, and indirect positive association with the frequency of internal war within the Chinese dynasties through drought and locust plagues.

Periodic temperature-associated drought/flood drives locust plagues in China.

Global warming is currently of great concern. Yet the ecological effects of low-frequency climate variations remain largely unknown. Recent analyses of interdecadal variability in population abundance of the Oriental migratory locust (Locusta migratoria manilensis) in China have revealed negative associations with temperature and positive associations with Yangtze drought and flood frequencies during the past millennium (AD 957-1956).

Relationship between increase rate of human plague in China and global climate index as revealed by cross-spectral and cross-wavelet analyses.

Plague has caused the death of hundreds of millions of people throughout the human history. Today this disease is again re-emerging and hence is again becoming an increasing threat to human health in several parts of the world. However, impacts of global climate variation (e.