Strategy for Fabricating Degradable Low-Surface-Energy Cross-Linked Networks with Excellent Anti-Fouling Properties.

Marine biofouling negatively impacts marine industries and ship navigation. However, current coatings are based on a single antifouling mechanism, which is insufficient to cope with the complex and ever-changing marine environment. Herein, multifunctional antifouling coatings were developed using a material system containing perfluoropolyether and caprolactone chains.

A Novel Oncogenic and Drug-Sensitive KIF5B-NTRK1 Fusion in Lung Adenocarcinoma.

We present a case of a lung adenocarcinoma patient harboring a novel kinesin family member 5B ()- gene fusion that responds well to entrectinib. Moreover, - gene chimera has been shown to be an oncogene, activating both the MAPK and PI3K/AKT signaling pathways. The biopsy sample was analyzed using various methods such as hematoxylin-eosin staining (HE), immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS) based on a 1267-gene panel.

Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system.

The downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive. Here, we reveal that Cadm4 undergoes specific palmitoylation at cysteine-347 (C347), which is crucial for its stable localization on the plasma membrane (PM). Mutation of C347 to alanine (C347A), blocking palmitoylation, causes Cadm4 internalization from the PM and subsequent degradation.

The disparity of platelet factor 4 and platelets in individuals of different ages.

The aging process profoundly impacts the systemic milieu, with specific blood-borne factors playing critical roles in its regulation. Platelet Factor 4 (PF4), released by platelets, has emerged as a novel blood-borne factor that contributes to the rejuvenation of aging brains in rodents. However, the age-related disparity in PF4 levels in humans remains poorly understood.

Deploying a Dipole Electric Field at the CsPbI Perovskite/Carbon Interface for Enhancing Hole Extraction and Photovoltaic Performance.

Carbon-based CsPbI perovskite solar cells without hole transporter (C-PSCs) have achieved intense attention due to its simple device structure and high chemical stability. However, the severe interface energy loss at the CsPbI/carbon interface, attributed to the lower hole selectivity for inefficient charge separation, greatly limits device performance. Hence, dipole electric field (DEF) is deployed at the above interface to address the above issue by using a pole molecule, 4-trifluoromethyl-Phenylammonium iodide (CF-PAI), in which the ─NH group anchors on the perovskite surface and the ─CF group extends away from it and connects with carbon electrode.

Spatially selective defect management of CsPbI films for high-performance carbon-based inorganic perovskite solar cells.

Defects formed at the surface, buried interface and grain boundaries (GB) of CsPbI perovskite films considerably limit photovoltaic performance. Such defects could be passivated effectively by the most prevalent post modification strategy without compromising the photoelectric properties of perovskite films, but it is still a great challenge to make this strategy comprehensive to different defects spatially distributed throughout the films. Herein, a spatially selective defect management (SSDM) strategy is developed to roundly passivate various defects at different locations within the perovskite film by a facile one-step treatment procedure using a piperazine-1,4-diium tetrafluoroborate (PZD(BF)) solution.

Palmitoylation is required for Sept8-204 and Sept5 to form vesicle-like structure and colocalize with synaptophysin.

Sept8 is a vesicle associated protein and there are two typical transcriptional variants (Sept8-204 and Sept8-201) expressed in mice brain. Interestingly, the coexpression of Sept8-204/Sept5 induces the formation of small sized vesicle-like structure, while that of the Sept8-201/Sept5 produces large puncta. Sept8 is previously shown to be palmitoylated.

Energy Harvesters and Self-Powered Sensors for Smart Electronics, 2nd Edition.

With the worldwide rollout of the 5G communication network and 6G around the corner, we have witnessed the rapid development of the Internet of Things (IoT) technology, enabling big data and digital transformation in various fields [...

The effect of ovarian injection of autologous platelet rich plasma in patients with poor ovarian responder: a systematic review and meta-analysis.

Objective: To evaluate the effects of ovarian injection of autologous platelet rich plasma (aPRP) on patients with poor ovarian responder (POR) based on the existing clinical evidence.

Methods: According to systematic review and meta-analysis, we comprehensively searched nine databases established as of September 6, 2023, and evaluated the impact of ovarian PRP infusion on poor ovarian responder. The research results include serum follicle-stimulating hormone(FSH) and anti-Mullerian hormone(AMH) levels, antral Follicle Count(AFC), oocyte number, and embryo number.

A Self-Powered Flexible Displacement Sensor Based on Triboelectric Effect for Linear Feed System.

The detection and feedback of displacement and velocity significantly impact the control accuracy of the linear feed system. In this study, we propose a flexible and self-powered displacement sensor based on the triboelectric effect, designed for seamless integration into linear feed systems. The displacement sensor comprises two parts, the mover and stator, operating in a sliding mode.

Correlation between long non-coding RNA MAFG-AS1 and cancer prognosis: a meta-analysis.

Background: MAF transcription factor G antisense RNA 1 (MAFG-AS1), a novel long non-coding RNA discovered recently, was proved to be useful in predicting malignancy prognosis. Nevertheless, its association with cancer prognosis has been inconsistent. Therefore, this meta-analysis aimed to explore the clinicopathological and prognostic significance of MAFG-AS1 in diverse carcinomas.

Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics.

Septin proteins are involved in diverse physiological functions, including the formation of specialized cytoskeletal structures. Septin 8 (Sept8) is implicated in spine morphogenesis and dendritic branching through palmitoylation. We explored the role and regulation of a Sept8 variant in human neural-like cells and in the mouse brain.

Novel miniature transendoscopic telerobotic system for endoscopic submucosal dissection (with videos).

Background And Aims: The lack of tissue traction and instrument dexterity to allow for adequate visualization and effective dissection were the main issues in performing endoscopic submucosal dissection (ESD). Robot-assisted systems may provide advantages. In this study we developed a novel transendoscopic telerobotic system and evaluated its performance in ESD.

Electrodeposition of High-Quality Ni/SiC Composite Coatings by Using Binary Non-Ionic Surfactants.

In order to increase the hardness, wear resistance and corrosion resistance of nickel-based coatings, pure nickel is often co-electrodeposited with silicon carbide (SiC) particles. However, SiC particles tend to agglomerate and precipitate in the bath, which reduces the amounts of nanoparticles and causes nonuniformity. Herein, we solve these problems by using binary non-ionic surfactants (Span 80 and Tween 60) to effectively disperse SiC particles (binary-SiC) in the bath, which suppresses nanoparticles agglomeration and leads to uniformly distributed SiC particles in the composite coatings.

Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway.

Purpose: Epithelial cystatin SN (CST1), a type 2 cysteine protease inhibitor, was significantly upregulated in asthma. In this study, we aimed to investigate the potential role and mechanism of CST1 in eosinophilic inflammation in asthma.

Methods: Bioinformatics analysis on Gene Expression Omnibus datasets were used to explore the expression of CST1 in asthma.

Intelligent Cubic-Designed Piezoelectric Node (iCUPE) with Simultaneous Sensing and Energy Harvesting Ability toward Self-Sustained Artificial Intelligence of Things (AIoT).

The evolution of artificial intelligence of things (AIoT) drastically facilitates the development of a smart city comprehensive perception and seamless communication. As a foundation, various AIoT nodes are experiencing low integration and poor sustainability issues. Herein, a cubic-designed intelligent piezoelectric AIoT node iCUPE is presented, which integrates a high-performance energy harvesting and self-powered sensing module a micromachined lead zirconate titanate (PZT) thick-film-based high-frequency (HF)-piezoelectric generator (PEG) and poly(vinylidene fluoride--trifluoroethylene) (P(VDF-TrFE)) nanofiber thin-film-based low-frequency (LF)-PEGs, respectively.

Inclusion Complexes of Photosensitizers with Cyclodextrins for Enhancing the Fabrication of Volume Grating.

A supramolecule photosensitizer (supra-photosensitizer) based on the host-guest complexation of cyclodextrins and a bis-chalcone dye (BDEA) was prepared. Methyl-β-cyclodextrin (Me-β-CD), with the highest inclusion rate, was confirmed as the best host among the four cyclodextrins. The host-guest properties of Me-β-CD and BDEA were characterized by FTIR, XRD, H NMR, PLQY, SEM, Job's plot, Benesi-Hildebrand plot, and others.

A wear and heat-resistant hydrophobic fluoride-free coating based on modified nanoparticles and waterborne-modified polyacrylic resin.

Hydrophobic coatings have attracted extensive research due to their broad application prospects. However, hydrophobic coatings in practical applications are often limited by their insufficient stability and are difficult to be applied on a large scale. In this regard, wear and heat resistance are key aspects that must be considered.

Dimethyl sulfoxide: a promising solvent for inorganic CsPbI perovskite.

Inorganic CsPbI perovskite is an important photovoltaic material due to its suitable band gap and high chemical stability. However, it is a challenge to grow high-quality CsPbI perovskite because the stability of perovskite phase is low and is sensitive to solvent. So far, most of CsPbI perovskites in high-performance perovskite solar cells (PSCs) were prepared from N,N-dimethylformamide, a highly toxic solvent, and no successful case has been reported for dimethyl sulfoxide (DMSO), which is environmentally-friendly with considerably higher complexation capability.

Electrodeposition of Polyporous Sn-Ni Coating in Deep Eutectic Solvents for Removing Organic Dyes.

Materials with a high specific surface area including a porous structure have been widely researched due to the applicability in the adsorption of various organic dyes. However, further application of porous materials is limited by the complicated and expensive preparation process. Herein, a Sn-Ni coating with a polyporous structure is successfully prepared via a simple and high-efficiency electrodeposition approach in deep eutectic solvents (DESs).

Epigenetic regulation of aging: implications for interventions of aging and diseases.

Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA (ncRNA) regulation, and RNA modification, all of which participate in the regulation of the aging process, and hence contribute to aging-related diseases. Therefore, understanding the epigenetic mechanisms in aging will provide new avenues to develop strategies to delay aging.

Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons.

The dynamics of synaptic vesicles (SVs) within presynaptic domains are tightly controlled by synapsin1 phosphorylation; however, the mechanism underlying the anchoring of synapsin1 with F-actin or SVs is not yet fully understood. Here, we found that Syn1 is modified with protein palmitoylation, and examining the roles of Syn1 palmitoylation in neurons led us to uncover that Syn1 palmitoylation is negatively regulated by its phosphorylation; together, they manipulate the clustering and redistribution of SVs. Using the combined approaches of electron microscopy and genetics, we revealed that Syn1 palmitoylation is vital for its binding with F-actin but not SVs.

Elevated CXCL14 in Induced Sputum Was Associated with Eosinophilic Inflammation and Airway Obstruction in Patients with Asthma.

Introduction: CXCL14 involved in inflammatory processes was upregulated in the asthma expression profile datasets in our pilot study. However, the expression of CXCL14 in induced sputum and its potential clinical role in asthma were poorly reported.

Objective: We sought to detect CXCL14 expression in airway epithelium and induced sputum cells of asthma and explore its potential clinical implications.