4D Printing Self-Sensing and Load-Carrying Smart Components.

In the past decade, 4D printing has received attention in the aerospace, automotive, robotics, and biomedical fields due to its lightweight structure and high productivity. Combining stimulus-responsive materials with 3D printing technology, which enables controllable changes in shape and mechanical properties, is a new technology for building smart bearing structures. A multilayer smart truss structural component with self-sensing function is designed, and an internal stress calibration strategy is established to better adapt to asymmetric loads.

Treatment of acral and mucosal melanoma: Current and emerging targeted therapies.

Targeted therapies revolutionized the management of patients with advanced and metastatic cutaneous melanoma. However, despite recent advances in the understanding of the molecular drivers of melanoma and its treatment with targeted therapies, patients with rare and aggressive melanoma subtypes, including acral melanoma (AM) and mucosal melanomas (MM), show limited long-term clinical benefit from current targeted therapies. While patients with AM or MM and BRAF or KIT mutations may benefit from targeted therapies, the frequency of these mutations is relatively low, and there are no genotype-specific treatments for most patients with AM or MM who lack common driver mutations.