Sera and lungs metabonomics reveals key metabolites of resveratrol protecting against PAH in rats.

Pulmonary arterial hypertension (PAH) is a type of high morbidity and mortality disease. Currently, the intrinsic metabolic alteration and potential mechanism of PAH are still not fully uncovered. Previously, we have found that polyphenol resveratrol (Rev) reversed the remodeling of the pulmonary vasculature and decreased the number of mitochondria in pulmonary arterial smooth muscle cells (PASMCs) (Lei Yu et al.

Chemical constituents from the fruits of L. and their vascular relaxation effect on rat mesenteric arteries.

Eight compounds were obtained from the dry fruits of L., and their potential vascular relaxant activities were explored. The present study first revealed the access of Rosin () and Piperchabaoside () in the medicinal plant L.

The vascular dilatation induced by Hydroxysafflor yellow A (HSYA) on rat mesenteric artery through TRPV4-dependent calcium influx in endothelial cells.

Ethnopharmacological Relevance: Hydroxysafflor yellow A (HSYA) is the principal constituent of the flowers of Carthamus tinctorius L., a traditional Chinese herbal medicine, which has been used for the treatment of cerebrovascular and cardiovascular diseases due to its property of promoting blood circulation and removing blood stasis. It is dominated in the water extract of Carthamus tinctorius L.