Publications by authors named "Huichan Liu"
Hepatitis E virus infection upregulates ING5 expression and .
Acta Biochim Biophys Sin (Shanghai)
June 2024
Article Synopsis
- Hepatitis E virus (HEV) is a key cause of viral hepatitis and poses a greater risk of chronic hepatitis and liver cancer in immunocompromised individuals.
- The study investigates the role of the tumor suppressor protein ING5 in relation to HEV infection using both acute and chronic animal models.
- Findings reveal that HEV infection significantly increases ING5 expression in the livers of mice and macaques, as well as in human liver cells, highlighting its potential importance in understanding HEV-related diseases.
Article Synopsis
- Hepatitis E virus (HEV) has been found in the female genital tract, which had not been previously reported, indicating a potential link to reproductive health issues.
- Vaginal secretions, cervical smears, and cervix uteri samples showed the presence of HEV RNA and antigens, suggesting the virus can be transmitted in women.
- In experimental models, HEV caused significant damage to the genital tract and heightened inflammatory responses, showing the virus’s impact on female reproductive health.
Article Synopsis
- HEV infection in pregnant women can lead to serious outcomes such as maternal death, stillbirth, and complications during pregnancy.
- Research of placenta from HEV-4 infected women showed that the virus replicates in the placenta and can be transmitted to fetuses, causing significant damage and inflammation.
- The study indicates that differences in immune responses between infected pregnant and non-pregnant women may play a role in the severity of the outcomes associated with HEV-4 infection.
Background: Hepatitis E virus (HEV) infection causes serious adverse pregnancy outcomes during pregnancy. However, the maternal and fetal damage induced by HEV infection is rarely reported.
Methods: A BALB/c pregnant mouse model was established to explore the maternal and fetal pathological damage and inflammatory responses caused by HEV infection.
The successful launch of Luojia 1-01 complements the existing nighttime light data with a high spatial resolution of 130 m. This paper is the first study to assess the potential of using Luojia 1-01 nighttime light imagery for investigating artificial light pollution. Eight Luojia 1-01 images were selected to conduct geometric correction.
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