Integrated analysis of single-cell RNA sequencing and bulk transcriptome data identifies a pyroptosis-associated diagnostic model for Parkinson's disease.

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by an insidious onset. Despite the emphasis on motor symptom-based diagnosis, there remains an unmet clinical need for effective diagnostic approaches during the prodromal phase of PD. Recent advances in single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic analyses of PD patients open avenues for identifying potential diagnostic biomarkers.

VAR-tree model based spatio-temporal characterization and prediction of O concentration in China.

Ozone (O) pollution in the atmosphere is getting worse in many cities. In order to improve the accuracy of O prediction and obtain the spatial distribution of O concentration over a continuous period of time, this paper proposes a VAR-XGBoost model based on Vector autoregression (VAR), Kriging method and XGBoost (Extreme Gradient Boosting). China is used as an example and its spatial distribution of O is simulated.

Spatio-Temporal Characteristics of PM Concentrations in China Based on Multiple Sources of Data and LUR-GBM during 2016-2021.

Fine particulate matter (PM) has a continuing impact on the environment, climate change and human health. In order to improve the accuracy of PM estimation and obtain a continuous spatial distribution of PM concentration, this paper proposes a LUR-GBM model based on land-use regression (LUR), the Kriging method and LightGBM (light gradient boosting machine). Firstly, this study modelled the spatial distribution of PM in the Chinese region by obtaining PM concentration data from monitoring stations in the Chinese study region and established a PM mass concentration estimation method based on the LUR-GBM model by combining data on land use type, meteorology, topography, vegetation index, population density, traffic and pollution sources.

Parent-Child Attachment and Social Adaptation Behavior in Chinese College Students: The Mediating Role of School Bonding.

Family and school are two main places for adolescents to develop socialization, which can be contributed by good parent-child attachment and school bonding. Earlier studies suggested that parent-child attachment played an important role in promoting the formation of high-level school bonding, which is also likely to influence social adaptation. This study aimed to explore the relationship between parent-child attachment and social adaptation, and the mediating role of school bonding.