Biomimetic HA-GO implant coating for enhanced osseointegration via macrophage M2 polarization-induced osteo-immunomodulation.

The pro-inflammatory/anti-inflammatory polarized phenotypes of macrophages (M1/M2) can be used to predict the success of implant integration. Hence, activating and inducing the transformation of immunocytes that promote tissue repair appears to be a highly promising strategy for facilitating osteo-anagenesis. In a previous study, titanium implants were coated with a graphene oxide-hydroxyapatite (GO-HA) nanocomposite via electrophoretic deposition, and the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) was found to be significantly enhanced when the GO content was 2wt%.

A new organic soluble cucurbit[7]uril-truxene derivative as stationary phase for gas chromatographic separation of some challenging isomers.

The insolubility of parent cucurbit[n]uril or substituted-cucurbit[n]uril derivatives in organic solvents has always been a key factor restricting the column efficiency and selectivity of capillary gas chromatography column based on cucurbit[n]uril. In this work, a novel organic soluble cucurbit [7]uril-truxene derivative (Q [7]-Tr) was synthesized by Heck coupling reaction between the mono-iodinated hexahexyl-truxene and 4-vinylbenzyloxy-Q [7]. A capillary gas chromatographic column was prepared by static method with this derivative as stationary phase.

Thermal responses of face-masked pedestrians during summer: An outdoor investigation under tree-shaded areas.

During the SARS-CoV-2 (COVID-19) pandemic, most citizens were cooperative towards the face-masking policy; however, undeniably, face masking has increased complaints of thermal discomfort to varying degrees and resulted in potential health hazards during summer. Thus, a thermal comfort survey was conducted under tree-shaded areas generally preferred by pedestrians to explore the thermal response of face-masked pedestrians. Thirty-two subjects, with and without masks, participated in walking experiments, and their thermal parameters and physiological indicators were recorded; moreover, the subjects were asked to fill in subjective questionnaires.

Graphene/hydroxyapatite coating deposit on titanium alloys for implant application.

Titanium (Ti) implants are widely used in medicine. Meanwhile, surface modification of Ti can strengthen the osseointegration of implants. In this study, we modified Ti implant surfaces, which was coated with GO, HA, HA-2wt%GO and HA-5wt%GO via electrophoresis deposition, to investigate their mechanisms and biological activity.

Borderline Developmental Dysplasia of the Hip: A Risk Factor Predicting the Development and Poor Prognosis after Core Decompression for Idiopathic Osteonecrosis of the Femoral Head.

Objective: It is unclear whether idiopathic osteonecrosis of the femoral head (ONFH) is associated with borderline developmental dysplasia of the hip (BDDH). This study aimed to compare the incidence of BDDH between patients with idiopathic ONFH and matched control subjects and determine the influence of BDDH on poor prognosis after core decompression (CD).

Methods: We retrospectively examined 78 consecutive patients (111 hips) with idiopathic ONFH undergoing CD and 1:2 matched with 156 control subjects (222 hips).

A 3-Year Clinical Evaluation of Endodontically Treated Posterior Teeth Restored with Resin Nanoceramic Computer-Aided Design/Computer-Aided Manufacture (CAD/CAM)-Fabricated Partial Crowns.

BACKGROUND We aimed to investigate the clinical effects of resin nanoceramic (RNC) computer-aided design/computer-aided manufacture (CAD/CAM) partial crowns on posterior teeth after root canal treatment over a 3-year period. MATERIAL AND METHODS A total of 132 posterior teeth restored with CAD/CAM partial crowns were placed in 128 patients. The observation group (n=66) was restored with RNC restorations, while the control group received lithium disilicate-based glass ceramic (LDGC) CAD restorations.

Differential circRNA and mRNA Expression Profiling During Osteogenic Differentiation in Rat Bone Marrow Mesenchymal Stem Cells.

BACKGROUND Circular RNAs (circRNAs) play important roles in gene expression and signaling pathways. The study aimed to identify the differential expression of circRNAs and mRNAs in the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs) and to explore the biological function of circRNAs in the osteogenic differentiation of rBMSCs. MATERIAL AND METHODS High-throughput sequencing was used to detect differentially expressed circular RNA and mRNA during osteogenic differentiation of rBMSCs.

Comprehensive analysis of lncRNA-miRNA-mRNA networks during osteogenic differentiation of bone marrow mesenchymal stem cells.

Background: Long non-coding RNA (lncRNA) plays crucial role in osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs), involving in regulation of competing endogenous RNA (ceRNA) mechanisms and conduction of signaling pathways. However, its mechanisms are poorly understood. This study aimed to investigate lncRNAs, miRNAs and mRNAs expression profiles in rat BMMSCs (rBMMSCs) osteogenic differentiation, screen the potential key lncRNA-miRNA-mRNA networks, explore the putative functions and identify the key molecules, as the basis of studying potential mechanism of rBMMSCs osteogenic differentiation driven by lncRNA, providing molecular targets for the management of bone defect.

Permanent Maxillary Odontometrics for Sex Estimation Based on a 3-Dimensional Digital Method.

BACKGROUND In the field of forensic medicine, sex estimation is a critical step in personal identification. Teeth are the hardest tissue and have high temperature resistance and corrosion resistance. In cases such as an airplane crash or the corpse of an unknown person, teeth often play a crucial role in identification.

Efficient ∼4 µm emission from Pr/Yb co-doped fluoroindate glass.

/ co-doped fluoroindate () glasses were prepared by using a traditional melt-quenching method in dry atmosphere. Pumped by a 976 or 1570 nm laser diode, efficient emissions at ∼4µ were obtained from the / co-doped glasses, which could be ascribed to the transition → of ions. The relative stimulated emission cross section was calculated to be ∼1.

Superaerophobic copper-based nanowires array for efficient nitrogen reduction.

Electrocatalytic N reduction reaction (NRR) provides a promising route for NH production under ambient conditions to replace traditional Haber-Bosch process. For this purpose, efficient NRR electrocatalysts with high NH yield rate and high Faradaic efficiency (FE) are required. Cu-based materials have been recognized catalytic active for some multi-electron-involved reduction reactions and usually exhibit inferior catalytic activities for hydrogen evolution reaction.

Low-Cost and Convenient Microchannel Resistance Biosensing Platform by Directly Translating Biorecognition into a Current Signal.

We report a low-cost and convenient microchannel resistance (MCR) biosensing platform that uses current signal to report biorecognition. The biorecognition behavior between targets and biometric molecules (antigens, antibodies, or oligonucleotides) immobilized on magnetic beads and polystyrene (PS) microspheres induces a quantitative change in the unreacted PS microspheres. After magnetic separation, the unreacted PS microsphere solution is passed through the microchannel, leading to an obvious blocking effect, resulting in an increase in resistance, which can in turn be measured by monitoring the electric current.

Quantitative control of noise in mammalian gene expression by dynamic histone regulation.

Fluctuation ('noise') in gene expression is critical for mammalian cellular processes. Numerous mechanisms contribute to its origins, yet the mechanisms behind large fluctuations that are induced by single transcriptional activators remain elusive. Here, we probed putative mechanisms by studying the dynamic regulation of transcriptional activator binding, histone regulator inhibitors, chromatin accessibility, and levels of mRNAs and proteins in single cells.

Food Safety in Post-COVID-19 Pandemic: Challenges and Countermeasures.

Understanding food safety hazard risks is essential to avoid potential negative heath impacts in the food supply chain in a post-COVID-19 pandemic era. Development of strategies for virus direction in foods plays an important role in food safety and verification. Early warning, tracing, and detection should be implemented as an integrated system in order to mitigate thecoronavirus disease 2019 (COVID-19) outbreak, in which the detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is critical as it not only concerns screening of populations but also monitoring of possible contaminated sources such as the food supply chain.

Intense emission at ∼3.3 µm from Er-doped fluoroindate glass fiber.

Fluoroindate glass fibers with an doping concentration of ∼0.5 were fabricated by using a rod-in-tube method. Pumped by a 976 nm laser diode, intense emission at ∼3.

Dental measurements based on a three-dimensional digital technique: A comparative study on reliability and validity.

Objective: In orthodontics and prosthodontics fields, it is often necessary to measure the crown dimensions of patient's teeth for further diagnosis and treatment. This study aims to assess the reliability and validity of dental measurements by comparing three-dimensional (3D) measurement of digital model derived from 3D handheld scanner with electronic digital caliper measurement of plaster model, providing a promising technology for dentistry.

Design: The mesiodistal diameter, buccolingual diameter and clinical crown height of 2800 teeth were measured on 100 sets of maxillary and mandibular dental plaster models as well as on the corresponding 3D digital models obtained by structured light scanning of the plaster models.

Bacteriostatic effects of nanometer silver disinfectant on the biofilms in dental unit water lines.

Background/purpose: Dental unit water lines (DUWLs) may be contaminated by aerobic bacteria in clinical settings and comprehensive disinfecting methods should be considered without delay. Herein, this study aims to investigate the timeliness and dynamic bacteriostatic effects of different forms of nanometer silver (NMS) disinfectant on bio-film in DUWLs.

Materials And Methods: Bacterial DUWLs samples were respectively treated with different NMS forms, including liquid phase and solid phase at the concentrations of 0.

Ultrasensitive determination of organotin compounds in plastic food packaging and edible oils by sheathless capillary electrophoresis-electrospray ionization-mass spectrometry.

The determination of trace-amount organotins in plastic food packaging materials is of great significance in food safety. However, due to the complexity of organotins and sample treatment processes, it is still a challenging task. Here, we report a method for the sensitive and simultaneous determination of organotins in plastic food packaging materials and edible oils, by utilizing sheathless capillary electrophoresis-electrospray ionization-mass spectrometry.

Sensitive detection of benzophenone-type ultraviolet filters in plastic food packaging materials by sheathless capillary electrophoresis-electrospray ionization-tandem mass spectrometry.

While they are commonly used as ultraviolet (UV) filters in plastic food packaging materials, benzophenones (BPs) are reported as environmental endocrine disruptors, and some of them possess significant estrogenic activity. Therefore sensitive determination of the content of those UV filters in plastic polymers is of vital importance in safety assessment of food packaging materials. Here, the sheathless capillary electrophoresis-electrospray ionization-tandem mass spectrometry (CE-ESI-MS/MS) method is applied for the first time to sensitively detect BP-type UV filters in plastic food packaging materials.

[The ideneification of liver immune-related genes in obese mice induced by long-term high-fat diet].

Objective To investigate the expression levels of hepatic immune-related genes in C57BL/6J mice treated by high-fat diet. Methods Male C57BL/6J mice were treated by high-fat diet for 16 and 38 weeks, and the control group were given normal diet. The body mass and blood glucose levels were measured, and the liver slices were checked by HE staining.

[Distribution of WNT10A gene rs10177996 polymorphism between Han and Uygur populations in Xinjiang area].

Purpose: To explore the characteristics of distribution of WNT10A gene rs10177996 polymorphism between Han and Uygur populations in Xinjiang area.

Methods: A cross-sectional survey on 154 Han individuals in Urumqi area and 134 Uygur individuals in Kashgar area was performed. Buccal epithelial cells were harvested using Cotton swab scraping, and DNA was extracted by special kit.

Investigating bone chip formation in craniotomy.

In a craniotomy, the milling cutter is one of the most important cutting tools. The operating performance, tool durability and cutting damage to patients are influenced by the tool's sharpness, intensity and structure, whereas the cutting characteristics rely on interactions between the tool and the skull. In this study, an orthogonal cutting experiment during a craniotomy of fresh pig skulls was performed to investigate chip formation on the side cutting and face cutting of the skull using a high-speed camera.

Correlation between facial morphology and gene polymorphisms in the Uygur youth population.

Human facial morphology varies considerably among individuals and can be influenced by gene polymorphisms. We explored the effects of single nucleotide polymorphisms (SNPs) on facial features in the Uygur youth population of the Kashi area in Xinjiang, China. Saliva samples were collected from 578 volunteers, and 10 SNPs previously associated with variations in facial physiognomy were genotyped.