High-affinity ssDNA aptamer and chemiluminescent aptasensor for TIMP-1 detection in human serum.

TIMP-1 (Tissue Inhibitor of Metalloproteinases-1) is a protein involved in regulating extracellular matrix (ECM) degradation. It is recognized as a significant biomarker for cancer diagnosis. This study aimed to develop and characterize a single-stranded DNA (ssDNA) aptamer targeting human TIMP-1 protein with high affinity and specificity.

Interfacial engineering-based colonization of biofilms on polyethylene terephthalate (PET) surfaces: Implications for whole-cell biodegradation of microplastics.

Microplastic pollution has become a significant environmental issue. One of the most important sources and components of microplastics is polyester fabric - polyethylene terephthalate (PET). Because the catalytic depolymerization of PET typically requires specific conditions such as alkaline environments, specific solvents, or high temperatures, there is an urgent need for a simpler, eco-friendly solution with high degradation efficiency for managing the vast amounts of PET textile waste.

Characterizing PANoptosis gene signature in prognosis and chemosensitivity of colorectal cancer.

Background: PANoptosis is a cell death pathway involved in pyroptosis, apoptosis and necrosis, and plays a key role in the development of malignant tumors. However, the molecular signature of PANoptosis in colorectal cancer (CRC) prognosis has not been thoroughly explored. The present study aimed to develop a novel prognostic model based on PANoptosis-related genes in CRC.

Microplastic characteristics in rain/snow sampled from two northern Chinese cities.

Atmospheric precipitation is recognized as a significant source of environmental microplastics, especially in inland waters and remote areas. However, due to the limited availability of existing data, further information on microplastics in precipitation is essential. Therefore, this study aims to elucidate the contamination of microplastics in both snowfall and rainfall while identifying potential factors that may influence their presence during atmospheric deposition.

Corrigendum: Accuracy of a novel real-time continuous glucose monitoring system: a prospective self-controlled study in thirty hospitalized patients with type 2 diabetes.

[This corrects the article DOI: 10.3389/fendo.2024.

Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics.

High-quality schematic illustrations are fundamental to the publication of scientific achievements in biomedical research, which are crucial for effectively conveying complex biomedical concepts. However, creating such illustrations remains challenging for many researchers due to the need to devote a significant amount of time and effort to accomplish it. To address this need, we present the Generic Diagramming Platform (GDP, https://BioGDP.

TiCT MXene Based Electro-Ionic Soft Actuator with Potential for Wearable Finger Straps.

Soft electro-ionic actuators have received extensive research and attention due to their advantages such as low voltage response and adjustable deformation. However, they have not been able to enter the actual industry application like traditional rigid actuators; one of the reasons may be that the kinematic properties of actuators have been less studied. The electro-ionic actuator based on TiCT MXene-CNT/PPy electrode prepared in this paper shows good bending displacement (18.

RMVar 2.0: an updated database of functional variants in RNA modifications.

Evaluating the impact of genetic variants on RNA modifications (RMs) is crucial for identifying disease-associated variants and understanding the pathogenic mechanisms underlying human diseases. Previously, we developed a database called RMVar to catalog variants linked to RNA modifications in humans and mice. Here, we present an updated version RMVar 2.

Bibliometric analysis of occupational exposure in operating room from 1973 to 2022.

Objective: The purpose of this study is to identify and visualize from different perspectives the topic on occupational exposure in operating room (OEOR).

Methods: In the Web of Science Core Collection (WoSCC), all the half-century data were retrieved from January 1st, 1973 to December 31st, 2022. CiteSpace, VOSviewer and Excel 2019 were employed to analyze and visualize data, based on publications, countries, institutions, journals, authors, keywords.

Appropriate delay of primary tumour radiotherapy may lead to better long-term overall survival for non-small cell lung cancer treated with EGFR-TKIs.

Purpose: The most appropriate time of primary tumor radiotherapy in non-small cell lung cancer(NSCLC) with EGFR-TKIs remains unclear. The aim of this study was to investigate the effect of the time factor of primary tumor radiotherapy on long-term overall survival(OS)and provide a theoretical basis for further clinical research.

Patients And Methods: In total, 238 patients with EGFR-TKIs and OS ≥ 12 months were statistically analysed.

Prevalence and risk factors of antenatal depression in the first trimester: A real-world cross-sectional study in a developed district in South China.

Background: Antenatal depression may result in adverse outcomes for both the mother and the offspring. However, few studies have focused on the screening of pregnant women at a higher risk for antenatal depression in the first trimester. The present study aimed to assess the effect of lifestyle and family relationships on antenatal depression in the first trimester in a large Chinese population.

Eliciting psychiatric nurses' preferences for workplace violence prevention: a protocol for discrete choice experiment.

Introduction: Workplace violence against healthcare workers has become a serious global public health problem. The incidence of workplace violence towards Psychiatric nurses is higher than in all other medical institutions, up to 84.2% per year.

Nanozyme-Catalyzed Colorimetric Detection of the Total Antioxidant Capacity in Body Fluids by Paper-Based Microfluidic Chips.

Total antioxidants play a crucial role in human health, and detection of the total antioxidant capacity (TAC) has broad application prospects in fields such as food safety, environmental assessment, and disease diagnosis. However, a long detection time, cumbersome steps, high cost, reliance on professional equipment, and nonportability still remain significant challenges. In this work, an efficient strategy of point-of-care testing (POCT) of the TAC in body fluids by nanozyme-catalyzed colorimetric paper-based microfluidic sensors is proposed.

Accuracy of a novel real-time continuous glucose monitoring system: a prospective self-controlled study in thirty hospitalized patients with type 2 diabetes.

Aims: The present study aimed to investigate the accuracy of the Glunovo real-time continuous glucose monitoring system (rtCGMS).

Methods: We conducted a 14-day interstitial glucose level monitoring using Glunovo rtCGMS on thirty hospitalized patients with type 2 diabetes. The flash glucose monitoring (FGM) was used as a self-control.

Microfluidic chemistry assisted synthesis of cobalt quantum dot embedded nitrogen doped carbon with oxidase-like properties toward ascorbic acid detection.

Ascorbic acid (AA) is a powerful antioxidant in food safety and disease treatment. It is of great significance to develop a low-cost, high-stability, and easy-to-operate colorimetric method for quantitative detection of AA in food or human body. Although various nanozymes have been developed for the colorimetric detection of AA, the size regulation of the catalytic center of nanozymes remains a challenge.

Single-cell and multi-omics analyses highlight cancer-associated fibroblasts-induced immune evasion and epithelial mesenchymal transition for smoking bladder cancer.

Tobacco carcinogens are recognized as critical hazard factors for bladder tumorigenesis, affecting the prognosis of patients through aromatic amines components. However, the specific function of tobacco carcinogens and systematic assessment models in the prognosis of bladder cancer remains poorly elucidated. We retrieved bladder cancer specific tobacco carcinogens-related genes from Comparative Toxicogenomic Database, our Nanjing Bladder Cancer cohort and TCGA database.

γ-Glutamylcysteine ameliorates blood-brain barrier permeability and neutrophil extracellular traps formation after ischemic stroke by modulating Wnt/β-catenin signalling in mice.

During the inflammatory response after stroke, the blood-brain barrier (BBB) is significantly disrupted, compromising its integrity. This disruption allows many peripheral neutrophils to infiltrate the injury site in the brain and release neutrophil extracellular traps (NETs), which further increase BBB permeability. In this study, we aimed to investigate the protective effects of γ-Glutamylcysteine (γ-GC), an immediate precursor of GSH, against BBB breakdown and NET formation after ischemic stroke.

Eliciting Depression Patients' Preferences for Medication Management: A Protocol for Discrete Choice Experiment.

Introduction: Depression threatens people's lives and imposes huge economic burden. Antidepressant therapy is the first-line treatment for depression, and patient adherence to medication is the key to successful treatment. Depression patients have poor medication adherence, which leads to failure of depression management and significantly poorer clinical outcomes.