F-53B stimulated vascular smooth muscle cell phenotypic switch and vascular remodeling via ferroptosis-related pathway.

The compound 6:2 chlorinated polyfluorinated ether sulfonate (F53B), an alternative to perfluorooctane sulfonate (PFOS), has been widely utilized in China. Although the connection between the exposure and toxicity of F53B is established, the role and mechanisms of the compound in promoting vascular remodeling are yet to be elucidated. Thus, the present study investigated the impact of F53B on the function of vascular smooth muscle cells (VSMCs) and vascular remodeling.

Differences of microplastics and nanoplastics in urban waters: Environmental behaviors, hazards, and removal.

Microplastics (MPs) and nanoplastics (NPs) are ubiquitous in the aquatic environment and have caused widespread concerns globally due to their potential hazards to humans. Especially, NPs have smaller sizes and higher penetrability, and therefore can penetrate the human barrier more easily and may pose potentially higher risks than MPs. Currently, most reviews have overlooked the differences between MPs and NPs and conflated them in the discussions.

Compound heterozygosity for Southeast Asian hereditary persistence of fetal hemoglobin and β0-thalassemia results in thalassemia intermedia: Pedigree analysis and genetic research in a family from South China. A case report.

Rationale: Compound heterozygotes for deletional β-thalassemia can be difficult to diagnose due to its diverse clinical presentations and no routine screenings. This can lead to disease progression and delay in treatment.

Patient Concerns: We reported pedigree analysis and genetic research in a family with rare β-thalassemia.

Role of Carbonyl Compounds for -Nitrosamine Formation during Nitrosation: Kinetics and Mechanisms.

-Nitrosamines are potential human carcinogens frequently detected in natural and engineered aquatic systems. This study sheds light on the role of carbonyl compounds in the formation of -nitrosamines by nitrosation of five secondary amines via different pathways. The results showed that compared to a control system, the presence of formaldehyde enhances the formation of -nitrosamines by a factor of 5-152 at pH 7, depending on the structure of the secondary amines.

BiFeO/rGO nanocomposite with visible light photocatalytic performance for tetracycline degradation.

Bismuth-iron semiconductor materials have been widely studied in the photocatalytic field due to their excellent light responsiveness. Among them, the potential and mechanism regarding photocatalytic degradation of organic pollutants by BiFeO are seriously ignored. In this research, BiFeO/reduced graphene oxide (BFO/rGO) was successfully synthesized for tetracycline (TC) removal.

Polystyrene nanoplastics induce vascular stenosis via regulation of the PIWI-interacting RNA expression profile.

Nanoplastics (NPs) have become common worldwide and attracted increasing attention due to their serious toxic effects. Owing to their higher surface area and volume ratios and ability to easily enter tissues, NPs impose more serious toxic effects than microplastics. However, the effect of NP exposure on vascular stenosis remains unclear.

A novel tiRNA-Glu-CTC induces nanoplastics accelerated vascular smooth muscle cell phenotypic switching and vascular injury through mitochondrial damage.

Nanoplastics pose several health hazards, especially vascular toxicity. Transfer RNA-derived small RNAs (tsRNAs) are novel noncoding RNAs associated with different pathological processes. However, their biological roles and mechanisms in aberrant vascular smooth muscle cell (VSMC) plasticity and vascular injury are unclear.

Chrysin prevents inflammation-coinciding liver steatosis via AMPK signalling.

Objectives: We aimed to elucidate the therapeutic potential of Chrysin (CN) against the high-fat diet (HFD) induced non-alcoholic fatty liver disease (NAFLD) and its mechanism.

Methods: To assess the hypothesis, NAFLD was induced in C57BL/6 mice by feeding a high-fat diet for up to two months, followed by CN administration (for three months). Liver injury/toxicity, lipid deposition, inflammation and fibrosis were detected via molecular and biochemical analysis, including blood chemistry, immunoimaging and immunoblotting.

BiMoO nanoparticles anchored in BiOI: A p-n heterojunction photocatalyst to enhance water purification.

Selective constructing of heterojunctions enables directional electron-hole migration and favorable charge separation. In this study, a novel p-n junction BiMoO (BMO) nanoparticles anchored in BiOI construct by hydrothermal and subsequent in-situ synthesis. The construction of tight heterojunctions that enhance the characteristic absorption of visible light by BiMoO/BiOI (BIMO) and expose more reactive sites can be used to facilitate the rapid degradation of antibiotics (Tetracycline, TC), endocrine disruptors (Bisphenol A, BPA) and dyes in water.

The potential risks posed by micro-nanoplastics to the safety of disinfected drinking water.

Micro-nanoplastics (M-NPs) have become an emerging critical issue in the environment because they migrate easily, can bioaccumulate with toxic effects, and are difficult to degrade. Unfortunately, the current technologies for removing or degrading M-NPs in drinking water are insufficient to eliminate them completely, and residual M-NPs in drinking water may pose a threat to human health by impairing human immunity and metabolism. In addition to their intrinsic toxic effects, M-NPs may be even more harmful after drinking water disinfection than before disinfection.

Transcriptome-wide m6A modification mediates cardiotoxicity in mice after chronic exposure to microplastics.

The widespread presence of microplastics (MPs) has garnered attention owing to their possible adverse effects. However, the cardiotoxicity of MPs and their underlying mechanism remains unclear. N6-methyladenosine (m6A) modification contributes to post-transcriptional modulation of gene expression, but whether this modification is relevant to MP-induced cardiotoxicity is unknown.

Enhanced Degradation of Antibiotic by Peroxydisulfate Catalysis with CuO@CNT: Simultaneous O Oxidation and Electron-Transfer Regime.

The nonradical process in the peroxydisulfate (PDS) oxidation system is a promising method for antibiotic removal in water. In this study, CuO@CNT was successfully synthesized by a facile approach to catalyze PDS. The removal efficiency of the antibiotic sulfamethoxazole (SMX) was 90.

EPI Light Field Depth Estimation Based on a Directional Relationship Model and Multiviewpoint Attention Mechanism.

Light field (LF) image depth estimation is a critical technique for LF-related applications such as 3D reconstruction, target detection, and tracking. The refocusing property of LF images provide rich information for depth estimations; however, it is still challenging in cases of occlusion regions, edge regions, noise interference, etc. The epipolar plane image (EPI) of LF can effectively deal with the depth estimation because of its characteristics of multidirectionality and pixel consistency-in which the LF depth estimations are converted to calculate the EPI slope.

Whole transcriptome sequencing analysis revealed key RNA profiles and toxicity in mice after chronic exposure to microplastics.

Investigating the long-term effects of microplastics (MPs) in vivo is necessary for evaluating its biological toxicity. Previously, we showed that MPs elicit vascular dysfunctions in atherosclerotic mice. However, the effects of long-term treatment with environmental levels of MPs on biological functions and RNA expression profiles in wild-type mice are unknown.

Fast depth estimation with cost minimization for structured light field.

Depth estimation is a fundamental task in light field (LF) related applications. However, conventional light field suffers from the lack of features, which introduces depth ambiguity and heavy computation load to depth estimation. In this paper, we introduce phase light field (PLF), which uses sinusoidal fringes as patterns and the latent phases as the codes.

HBCD, TBECH, and BTBPE exhibit cytotoxic effects in human vascular endothelial cells by regulating mitochondria function and ROS production.

Brominated flame retardants (BFRs), such as, 1,2,5,6-tetrabromocyclooctane (HBCD), 1,2-dibromo-4-(1,2-dibromopropyl)cyclohexane (TBECH), and 1 1,2-bis-(2,4,6-tribromophenoxy)ethane (BTBPE), have garnered increasing attention due to their potent biological effects. In the present study, the toxicity of HBCD, TBECH, and BTBPE in human vascular endothelial cells (ECs) was explored. The data showed that HBCD, TBECH, and BTBPE induced cytotoxicity, namely dose-dependent cell viability reduction, cell membrane permeability and apoptosis increase, migration, and lumen formation inhibition.

Thiourea-assisted one-step fabrication of a novel nitrogen and sulfur co-doped biochar from nanocellulose as metal-free catalyst for efficient activation of peroxymonosulfate.

The N, S co-doped biochar (N, S-BC) with multistage pore structure was successfully synthesized from nanocellulose and thiourea by one-step pyrolysis, which could effectively activate peroxymonosulfate (PMS) to degrade sulfamethoxazole (SMX) in water. Moreover, the removal efficiency of SMX by this oxidation system was 2.3-3.

Management of a "suspected ward" in a COVID-19 designated hospital in Wuhan.

During December 2019, an outbreak of unexplained pneumonia occurred in Wuhan, Hubei Province. The disease was subsequently named coronavirus disease 2019 (COVID-19) and the causative virus as severe acute respiratory syndrome conronavirus-2 (SARS-CoV-2). Based on experience, it is vital to exclude or diagnose suspected patients as soon as possible to prevent disease spread.

Effect of Flow Configuration on Nitrifiers in Biological Activated Carbon Filters for Potable Water Production.

Up-flow biological activated carbon (BAC) filters have been empirically employed in drinking water treatment plants (DWTPs) to address the challenges of its down-flow counterparts (e.g., high head loss and insufficient use of BAC beds), yet their performances and mechanisms toward ammonia removal are not fully evaluated.

In Situ Regeneration of Phenol-Saturated Activated Carbon Fiber by an Electro-peroxymonosulfate Process.

Regeneration is required to restore the adsorption performance of activated carbon used as an adsorbent in water purification. Conventional thermal and electrochemical regenerations have high energy consumption and poor mineralization of pollutants, respectively. In this study, phenol-saturated activated carbon fiber was regenerated in situ using an electro-peroxymonosulfate (E-PMS) process, which mineralized the desorbed contaminants with relatively low energy consumption.

Transition element doped octahedral manganese molecular sieves (Me-OMS-2) as diclofenac adsorbents.

Diclofenac (DCF) control measures have become an area of increased interest for environmental researchers due to the high environmental concentration and risk of DCF. Adsorption seems to be promising for DCF removal from the aqueous phase because of its specific superiority in comparison with biodegradation, membrane separation, and advanced oxidation or reduction. In this study, OMS-2 and metal-doped OMS-2 ((Me-OMS-2, with Me = Co, Cu or Ce) were prepared and tested as adsorbents for the removal of DCF.

Simultaneous regeneration of cathodic activated carbon fiber and mineralization of desorbed contaminations by electro-peroxydisulfate process: Advantages and limitations.

This study investigated the regeneration of phenol saturated activated carbon fiber (ACF) with a novel electro-peroxydisulfate (E-PDS) process. Compared with traditional electrochemical regeneration, E-PDS process could simultaneously regenerate the exhausted ACF and mineralize desorbed contaminants by activating PDS in water with a much lower energy consumption (1/6). According to the estimation of relative contributions involved in E-PDS process, reactive oxygen species (ROS), especially sulfate radical (SO), played a dominant role in the degradation of phenol and its byproducts.

Multi-anchor spatial phase unwrapping for fringe projection profilometry.

Phase unwrapping is a necessary step in fringe-projection profilometry that produces accurate depth maps. However, the original wrapped phase is often corrupted by errors, and thus conventional spatial unwrapping suffers from error propagation, such as scanline-based unwrapping, and high complexity, such as quality-guided methods. In this paper, we propose a fast and robust spatial unwrapping method called multi-anchor scanline unwrapping (MASU).

Rapid removal of diclofenac in aqueous solution by soluble Mn(III) generated in a novel Electro-activated carbon fiber-permanganate (E-ACF-PM) process.

Electrolysis and permanganate (PM) oxidation are two commonly used technologies for water treatment. However, they are often handicapped by their slow reaction rates. To improve the removal efficiency of refractory contaminants, we combined electrolysis with PM using an activated carbon fiber (ACF) as cathode (E-ACF-PM) for the first time to treat diclofenac (DCF) in aqueous solution.