Publications by authors named "HuiMin Kang"

Article Synopsis
  • Excessive abdominal fat in chickens negatively impacts feed efficiency and slaughter yield, prompting a study on the genetic factors influencing fat deposition in Qingyuan partridge chickens.
  • Whole transcriptome sequencing of the duodenum revealed 116 differentially expressed genes linked to fat accumulation, including various types of RNAs like mRNAs, lncRNAs, circRNAs, and miRNAs.
  • Functional analyses identified important signaling pathways, such as Wnt and PPAR, involved in fat metabolism, suggesting candidate genes and RNA networks that could be targeted to improve breeding practices in broiler chickens.
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The endogenous FGF21 level is a potential target for diagnosing NAFLD. This study aimed to assess the clinical utility of FGF21 in diagnosing NAFLD and provide new ideas for predicting and preventing NAFLD. A total of 193 patients diagnosed with NAFLD based on diagnostic criteria and 64 healthy individuals were included in the NAFLD and non-NAFLD groups, respectively.

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Article Synopsis
  • - The study examines Krüppel-like factors (KLFs), a group of transcription factors found in various species, focusing on their gene family in chickens by analyzing conserved gene sequences from different animals.
  • - Several bioinformatics methods were used to analyze the chicken genome, leading to insights about the evolutionary relationships, structural characteristics, and functions of KLFs, particularly noting that birds' KLFs are more similar to mammals and amphibians than to fish.
  • - Additionally, the research explored the role of miRNA-22 in influencing the expression of KLFs in the liver, heart, and muscle of Qingyuan partridge chickens, revealing that both interference and overexpression of this miRNA can affect gene expression levels.
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The liver of chickens is essential for maintaining physiological activities and homeostasis. This study aims to investigate the specific function and molecular regulatory mechanism of microRNA-122 (miR-122), which is highly expressed in chicken liver. A lentivirus-mediated overexpression vector of miR-122 was constructed and used to infect 12-day-old female Qingyuan Partridge chickens.

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  • Solid-state nuclear magnetic resonance (NMR) is an important technique for analyzing the structures and movements of insoluble proteins, particularly through complex multi-dimensional correlation experiments.
  • The introduction of a new method called POST-C4 (PC4) improves the efficiency of Cα-Cβ correlations, requiring less radio-frequency power while being stable and effective under specific conditions.
  • Comparative tests show that PC4 enhances these correlations by up to 50% compared to existing methods, addressing a critical need in structural biology for better C-C correlation techniques.
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  • The Qingyuan partridge chicken, a local Chinese breed, has been improved over 20 years for economic traits while retaining characteristic features like high meat quality and flavor.
  • A study of 134 chickens from two breeding and one preserved population revealed low inbreeding and high genetic diversity, offering potential for further development.
  • The research identified 42 significant genes related to breed-specific traits and growth, aiding genetic assessment and future breeding programs for the Qingyuan partridge chicken.
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  • - The study investigates the genetic factors affecting carcass traits in Tiannong partridge chickens, which are important for meat production efficiency.
  • - Researchers identified 12 key genes linked to carcass characteristics, with SERPINB6 being significant across multiple analyses and influencing cell growth.
  • - Findings suggest that the variant rs317934171 regulates SERPINB6 expression, revealing it as a potential target for improving chicken meat production traits.
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Qingyuan partridge chicken is a renowned indigenous yellow broiler breed in China. Egg production traits are important economic traits for chickens. With the decreasing cost of whole genome resequencing, identifying candidate genes with more precision has become possible.

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  • The study investigates the effects of nanosilica used in cigarette filters on the lung health of factory workers and mouse models.
  • Results show that workers exposed to cigarette filter silica exhibit significantly higher abnormal lung function rates compared to those in different roles at the factory.
  • Animal tests indicate that cigarette filter silica leads to more severe lung inflammation and impairment over time than crystalline silica, highlighting the need for better safety measures for workers handling these materials.
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This study aimed to investigate the mechanism of circ-POLA2 in colon cancer (CC). Circ-POLA2, miR-138-5p, and SEMA4C levels in CC tissues and cells were recorded. The influences mediated by circ-POLA2, miR-138-5p or SEMA4C on cell proliferation, migration, invasion, and apoptosis were determined.

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Additional phase modulation (APM) is proposed to generally enhance the theoretical efficiency of homonuclear double-quantum (DQ) recoupling in solid-state NMR. APM applies an additional phase list to DQ recoupling in steps of an entire block. The sine-based phase list can enhance the theoretical efficiency by 15-30 %, from 0.

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Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis of silicosis in order to identify preventive or therapeutic antifibrotic agents. However, the existing research on the mechanism of silica-dust-induced pulmonary fibrosis is only the tip of the iceberg and lags far behind clinical needs.

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Atractylenolide III (ATL-III) is a major active constituent of the natural plant Atractylodes rhizome. Our previous study has shown that ATL-III may alleviate alveolar macrophage apoptosis via the inhibition of the mammalian target of rapamycin (mTOR)-mediated autophagy of human silicosis. Therefore, we aimed to further explore the function of ATL-III in autophagy, apoptosis, and pulmonary fibrosis by establishing the ATL-III-intervened silicosis mouse model in this study.

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Recently, chiral hybrid organic-inorganic perovskites (HOIPs) are drawing wide attention due to their intrinsic noncentrosymmetric structures which result in fascinating properties such as ferroelectronics and second-order nonlinear optics (NLO). However, previous research mainly focused on chiral lead-based halide perovskites ignoring that the toxic Pb element is harmful to humans and the environment. Herein, we successfully synthesized block-like (-/-NEA)CuCl (NEA = 1-naphthylethylamine) and needle-like (-/-CYHEA)CuCl (CYHEA = 1-cyclohexylethylamine) single crystals, which crystallize in the Sohncke 2 and 2 space group, respectively.

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Objective: To investigate the clinical effect of Kinesio Taping combined with electroacupuncture in the treatment of Bigliani typeⅠsubacromial impingement syndrome.

Methods: From January 2019 to June 2021, 82 cases with Bigliani typeⅠsubacromial impingement syndrome were selected and divided into treatment group and control group. Treatment group included 41 cases, 23 males and 18 females, aged from 20 to 52 years old, with an average of (39.

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Article Synopsis
  • Qingyuan partridge chicken is a notable Chinese yellow broiler, with a focus on five traits analyzed at 105 days old: body weight (BW), comb height (CH), shank length (SL), shank girth (SG), and feather maturity (FM).
  • The study aimed to estimate genetic parameters, specifically direct additive genetic correlations, using about 9600 records and different multi-trait models to enhance breeding strategies.
  • Results showed varying heritability estimates for the traits, with direct heritabilities ranging from 0.14 to 0.53, and genetic correlations indicating some positive and negative associations among the traits, providing insights for selective breeding.
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Genomic selection (GS) is an efficient method to improve genetically economic traits. Feature selection is an important method for GS based on whole-genome sequencing (WGS) data. We investigated the prediction performance of GS of milk production traits using imputed WGS data on 7957 Chinese Holsteins.

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Background: The mortality rate of colorectal cancer (CRC) ranks second. circRNAs are abnormal expression in some diseases, and their dysregulation is associated with cancer progression. Recent studies have shown that the malignant progression of colorectal cancer is inseparable from the abnormal expression of circRNAs.

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Residual feed intake (RFI) is considered as a measurement of feed efficiency, which is greatly related to the growth performance in pigs. Daily feeding records can be obtained from automatic feeders. In general, RFI is usually calculated from the total measurement records during the whole test period.

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Chiral nanomaterials have drawn extensive attention on account of numerous application prospects in optoelectronics, asymmetric catalysis, chiral recognition, and three-dimensional (3D) display. Thereinto, chiral perovskite has been a hotspot due to brilliant optoelectronic properties, but some problems limit the development, including low quantum yield, low chiral intensity, and the lack of facile regulation. To overcome these issues, an effective ligand exchange strategy, .

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Background: In broiler production, breast muscle weight and intramuscular fat (IMF) content are important economic traits. Understanding the genetic mechanisms that underlie these traits is essential to implement effective genetic improvement programs. To date, genome-wide association studies (GWAS) and gene expression analyses have been performed to identify candidate genes for these traits.

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A novel fluorimetric and colorimetric chemosensor (1O) was synthesized with diarylethene-rhodamine unit and characterized by ESI-MS, H NMR, and C NMR. The chemosensor can selectively recognize extremely low concentrations of Hg over a variety of metal ions with remarkable colorimetric and fluorescent responses. The colorimetric and fluorescent changes were ascribed the reaction between 1O and Hg destructed the rhodamine hydrazide into open-ring form which was proved by mass spectrometry and nuclear magnetic titration analyses.

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Background: A body distribution with high intramuscular fat and low abdominal fat is the ideal goal for broiler breeding. Preadipocytes with different origins have differences in terms of metabolism and gene expression. The transcriptome analysis performed in this study of intramuscular preadipocytes (DIMFPs) and adipose tissue-derived preadipocytes (DAFPs) aimed to explore the characteristics of lipid deposition in different chicken preadipocytes by dedifferentiation in vitro.

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A lack of the complete pig proteome has left a gap in our knowledge of the pig genome and has restricted the feasibility of using pigs as a biomedical model. In this study, we developed a tissue-based proteome map using 34 major normal pig tissues. A total of 5841 unknown protein isoforms were identified and systematically characterized, including 2225 novel protein isoforms, 669 protein isoforms from 460 genes symbolized beginning with LOC, and 2947 protein isoforms without clear NCBI annotation in the current pig reference genome.

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Qingyuan partridge chicken is an important indigenous chicken in China. In its breeding schemes, chickens are usually selected at the age of 105-day-old for five traits, including body weight (BW), shank length (SL), shank girth (SG), comb height (CH) and feather maturity (FM). At present, genetic parameters of the aforementioned traits have still not been studied in Qingyuan partridge chickens.

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