mA transferase KIAA1429 mediates the upregulation of LncRNA LINC00968 promoting the progression of gastric cancer cells.

Background: The screening and monitoring of gastric cancer is still a clinical challenge. Both N-methyladenosine (mA) and lncRNAs have been evidenced as critical regulators of gastric cancer, but their interaction and potential in modulating tumor progression remain unclear. This study aimed to evaluate the function of lncRNA LINC00968 in gastric cancer biological processes, and we discovered the role of KIAA1429, a typical mA eraser, in mediating LINC00968 function.

Simultaneous Determination of Hormones in Botanical Dietary Supplements With Supramolecular Solvent-Based Extraction by HPLC-MS/MS.

Dietary supplements typically contain either natural products or synthetic chemicals. While botanical dietary supplements are often thought to be more natural and safer, they could still contain potentially harmful ingredients. Despite the detection of sex hormones in plants and soil, it is still worth examining if products made from plants contain them.

Exploring the phytotoxicity mechanisms of PET nanoplastics and 6:2 FTSA in water hyacinth under individual and combined exposure scenarios.

Due to its similarity in hydrophobic properties to perfluorooctanesulfonic acid (PFOS), 6:2 fluorotelomer sulfonic acid (6:2 FTSA) has emerged as a key substitute for PFOS. Its presence in aquatic environments, along with the coexistence of polyethylene terephthalate (PET), may impact the growth of aquatic plants and ecosystem stability. This study explored the changes in antioxidant defense, photosynthetic system, and metabolic responses of water hyacinths (Eichhornia crassipes) under individual and combined exposure conditions.

ROASMI: accelerating small molecule identification by repurposing retention data.

The limited replicability of retention data hinders its application in untargeted metabolomics for small molecule identification. While retention order models hold promise in addressing this issue, their predictive reliability is limited by uncertain generalizability. Here, we present the ROASMI model, which enables reliable prediction of retention order within a well-defined application domain by coupling data-driven molecular representation and mechanistic insights.

Pretreatment of enzymatic hydrolysis lignin based on deep eutectic solvent containing a reversibly-soluble base.

The pretreatment with green deep eutectic solvents (DESs) is conducive to realizing the high-efficiency utilization of lignin at a low cost. In this study, an innovative choline chloride/urea/calcium hydroxide (ChCl/UR/Ca(OH)) DES containing a reversibly-soluble base Ca(OH) was developed for the pretreatment of enzymatic hydrolysis lignin (EHL). The lignin pretreatment effects of the proposed ChCl/UR/Ca(OH) DES were compare with a series of DESs.

Quantification of microplastics released from plastic food containers during rinsing and migration by pyrolysis-gas chromatography/mass spectrometry.

In this study, a pyrolysis-gas chromatography/mass spectrometry method was established to quantify microplastics (MPs) released from plastic food containers during rinsing and migration. The inner surface of actual samples was rinsed with deionized water, and the MPs in rinse water were collected through a glass fiber membrane with pore size of 1 μm. Subsequently, thoroughly cleaned polypropylene (PP) food packaging containers were selected for migration tests under different simulants, migration temperatures, and migration times.

Functional role of DFR genes in various blue Iris for the regulation of delphinidin synthesis.

Flowers belonging to the Iris genus, with a predominant display of blue hues, showcase a variety of blue polymorphisms across different species. This study focused on analyzing the L∗, a∗, and b∗ color values of Iris typhifolia, I. lactea, I.

Down-regulation of miR-138-5p in PP2A KO mice promoted apoptosis of spermatocytes.

Background: Protein phosphatase 2 A (PP2A) is known to have a pivotal and diverse functions in various physiological processes. In the previous study, we utilized the cre-loxp system to generate germ cell-specific knockout mice for the PP2A catalytic subunit alpha subunit (Ppp2ca).

Methods And Results: Using high-throughput miRNA sequencing of testis tissues and real‑time PCR, we have identified a notable decrease in the expression of miR-138-5p in the testes of Ppp2ca mice.

Preparation and Application of Weak Cation Exchange Resin Based on Thiol Click Reaction.

Using poly(styrene-divinylbenzene) microspheres as stationary phase matrix and mercaptosuccinic acid as a modifier, a new weak cation exchange resin was synthesized by thiol click reaction. The conditions for thiol-chlorine click reaction and thiol-alkene click reaction were optimized. The surface morphology and chemical composition of the modified microspheres were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, and an elemental analyzer.

Gut microbiota mediate the alleviation effect of Xiehuo-Guzheng granules on β cell dedifferentiation in type 2 diabetes mellitus.

Background: Type 2 diabetes mellitus (T2DM) is a worldwide public health problem characterized by a progressive decline in β cell function. In traditional Chinese medicine (TCM) theory, 'fire' and 'healthy qi deficiency' are important pathogeneses of T2DM, and purging 'fire' and reinforcing the 'healthy qi' (Pinyin name: Xiehuo-Guzheng, XHGZ) are important method of treatment. Over the years, we have observed its benefit for diabetes.

Unlocking the night: Exploring the health impacts of night-time walking environments on health outcomes of older adults.

Walking remains the primary form of physical activity for many older adults in China, and the quality of the walking environment at night may determine the frequency and duration of evening outings. This study reveals how night-time environmental features influence the health outcomes of older adults. Using the medical check-up records of 87,578 older adults from a public health service in the Beilin district of Xi'an city, China, the role of the night-time walking environment in managing chronic conditions was examined.

The effect of comprehensive psychological interventions on the mental health of the community elderly.

Objective: To observe the intervention effect of comprehensive psychological interventions on the mental health of the elderly population.

Methods: 133 elderly aged 60 and above in two urban districts of Tianshui City from January 2020 to December 2020 were selected and divided into the intervention group (n=67) and the control group (n=66). The intervention group received comprehensive psychological interventions, with no intervention given to the control group.

A PLGA/Silk Fibroin Nanofibre Membrane Loaded with Natural Flavonoid Compounds Extracted from Green Cocoons for Wound Healing.

The use of biodegradable materials combined with natural metabolites in wound dressings has received much attention. Flavonoids (FLs) from green cocoons, as metabolites, have antibacterial, antioxidant, anti-inflammatory, and other pharmacological effects. In this study, composite membranes of FL-loaded polylactic glycolic acid (PLGA)/silk fibroin (SF) were prepared by an electrospinning method.

Spatial distribution of maternal factors in pig mature oocytes.

It is known that asymmetrical maternal transcripts play an important role in the cell fate of the early embryo, but few studies are available in mammal oocytes especially in pig. To investigate the spatial factors in pig oocytes, the oriented bisection was established for collecting karyoplasts (NSOs) and cytoplasts (SSOs) with more than 95% efficiency. Subsequently, RNA-Seq and LC-MS/MS analysis were performed on NSOs and SSOs.

Attenuation of renal fibrosis in mice due to lack of bombesin receptor-activated protein homologue.

Bombesin receptor-activated protein (BRAP), encoded by the C6orf89 gene in humans, is expressed in various cells with undefined functions. BC004004, the mouse homologue of C6orf89, has been shown to play a role in bleomycin-induced pulmonary fibrosis through the use of a BC004004 gene knockout mouse (BC004004). In this study, we investigated the potential involvement of BRAP in renal fibrosis using two mouse models: unilateral ureteral obstruction (UUO) and type 2 diabetes mellitus induced by combination of a high-fat diet (HFD) and streptozocin (STZ).

Effects of polystyrene microplastic composite with florfenicol on photosynthetic carbon assimilation of rice (Oryza sativa L.) seedlings: Light reactions, carbon reactions, and molecular metabolism.

The effects of co-exposure to antibiotics and microplastics in agricultural systems are still unclear. This study investigated the effects of florfenicol (FF) and polystyrene microplastics (PS-MPs) on photosynthetic carbon assimilation in rice seedlings. Both FF and PS-MPs inhibited photosynthesis, while PS-MPs can alleviate the toxicity of FF.

The phototoxicity of sulfamethoxazole stress on pakchoi cabbage (Brassica rapa var. chinensis) seedlings: From the perspective of photoreaction and omics analysis.

The increasing use of antibiotics has attracted widespread attention to their environmental risks. However, the phototoxicity of sulfonamide antibiotics to plants remain unclear. In this study, the mechanism of the effect of sulfamethoxazole on photosynthesis of pakchoi cabbage (Brassica rapa var.

[Application of ion chromatographic fingerprint analysis for quality evaluation of tobacco flavors].

Tobacco flavor, an important tobacco additive, is an essential raw material in cigarette production that can effectively improve the quality of tobacco products, add aroma and taste, and increase the suction flavor. The quality consistency of tobacco flavors affects the quality stability of branded cigarettes. Therefore, the quality control of tobacco flavors is a major concern for cigarette and flavor manufacturers.

Aging in chronic lung disease: Will anti-aging therapy be the key to the cure?

Chronic lung disease is the third leading cause of death globally, imposing huge burden of death, disability and healthcare costs. However, traditional pharmacotherapy has relatively limited effects in improving the cure rate and reducing the mortality of chronic lung disease. Thus, new treatments are urgently needed for the prevention and treatment of chronic lung disease.

Research on The Status Quo and Influencing Factors of Knowledge and Practice of Disaster Emergency Rescue of Nurses in Grade A Hospitals.

Context: Man-made disasters and natural disasters bring huge losses to human life and property. High-quality nursing teams play an important role in reducing casualty and disability rates in disaster areas, reducing the prognosis of the injured, accelerating community recovery and even promoting social rehabilitation. This work aimed to analyze the current situation and influencing factors of disaster emergency rescue (DER) of nurses in Hunan Province by surveying their knowledge, attitude, and practice of DER in Grade A hospitals.