Quality Grading Evaluation of Changii Radix Based on a Biology-Related Chemical Indicator Prediction Model.

Introduction: The quality of traditional Chinese medicine (TCM) is a prerequisite for clinical efficacy. However, the existing quality evaluation methods are not strongly correlated with efficacy, and they are unable to adequately reflect the quality grade of Changii Radix (CR).

Objectives: In this study, a biology-related chemical indicator quality grading prediction model was developed to predict the quality grade of CR.

Multilayer Brain Networks for Enhanced Decoding of Natural Hand Movements and Kinematic Parameters.

Decoding natural hand movements using Movement-Related Cortical Potentials (MRCPs) features is crucial for the natural control of neuroprosthetics. However, current research has primarily focused on the characteristics of individual channels or on brain networks within a single frequency or time segment, overlooking the potential of brain networks across multiple time-frequency domains. To address this problem, our study investigates the application of multilayer brain networks (MBNs) in decoding natural hand movements and kinematic parameters, using a combination of MRCPs features and MBNs metrics.

[A Retrospective Analysis of Irregular Erythrocyte Antibodies in the Blood Transfusion Department of People's Hospital of Xinjiang Uygur Autonomous Region from 2011 to 2022].

Objective: The distribution of irregular erythrocyte antibodies in the blood transfusion department of the People's Hospital of Xinjiang Uygur Autonomous Region from 2011 to 2022 and the relationship between irregular erythrocyte antibodies and ethnicity, gender, pregnancy history, blood transfusion history were retrospectively analyzed.

Methods: The irregular antibody screening data of patients who were proposed to receive blood transfusions in the clinical blood transfusion safety and blood management software of our hospital from 2011 to 2022 were collected for a retrospective study, and the distribution of irregular erythrocyte antibodies from 2011 to 2022 was analyzed. The relationship between ethnicity, gender, pregnancy history, blood transfusion history and the detection rate of irregular erythrocyte antibodies was further analyzed.

Administration of anticoagulation strategies for portal vein thrombosis in cirrhosis: network meta-analysis.

Objectives: Evidences for anticoagulation strategies in cirrhotic with portal vein thrombosis (PVT) are still insufficient. This study aims to comprehensively compare the therapeutic effects of different therapeutic therapeutic measures in individuals suffering from cirrhosis with PVT, with the ultimate goal of providing evidence-based recommendations for thrombolytic therapy in this population.

Methods: Starting from 20 October 2023, a comprehensive search about therapeutic strategies for portal vein thrombosis in cirrhosis was conducted on PubMed, EMBASE, and Cochrane Library.

Associations of short-term exposure to air pollution with outpatient visits and treatment costs for chronic obstructive pulmonary disease in Xinxiang, China (2016-2021).

The acute health effects of air pollution on the risk of chronic obstructive pulmonary disease (COPD) have not been adequately studied and results remain inconsistent. Furthermore, fewer studies have explored the impact of air pollution on the cost of treating patients with COPD. Generalized additive models (GAM) based on Poisson distribution and gamma were applied to evaluate the association between short-term exposure to air pollution and daily COPD outpatient visits and daily COPD treatment costs.

Overcoming the cognition-reality gap in robot-to-human handovers with anisotropic variable force guidance.

Object handover is a fundamental task for collaborative robots, particularly service robots. In in-home assistance scenarios, individuals often face constraints due to their posture and declining physical functions, necessitating high demands on robots for flexible real-time control and intuitive interactions. During robot-to-human handovers, individuals are limited to making perceptual judgements based on the appearance of the object and the consistent behaviour of the robot.

Integrated UHPLC-mS/mS analysis, spectrum-effect relationship, and molecular docking to study the antidiabetic components of .

The leaves of (Batal) Iljinsk., a plant native to China that has long been used in traditional Chinese medicine to treat diabetes. It remains to be determined what chemical constituents are responsible for this effect.

Airway microbiota dysbiosis and metabolic disorder in ozone and PM co-exposure induced lung inflammatory injury in mice.

Co-exposure to ground-level ozone (O) and fine particles (PM, ≤ 2.5 µm in diameter) has become a primary scenario for air pollution exposure of urbanites in China. Recent studies have suggested a synergistic effect of PM and O on induction of lung inflammatory injury.

Amino-functionalized HPU-23@Ru@Tb as light-driven oxidase-like nanozyme for colorimetric recognition of Hg and ratiometric fluorescence sensing of ClO and PO.

A HPU-23@Ru@Tb-NH sensor array with light-driven oxidase-mimicking activity and triple-emission fluorescence was developed. It was composed of a Tb-functionalized metal organic framework and Ru(bpy) and applied to the simultaneous detection of Hg, ClO, and PO via differently responsive channels. HPU-23@Ru@Tb-NH had a photoresponsive colorimetric response toward Hg with a LOD as low as 4.

Contrasting responses of soil bacterial and fungal networks to photovoltaic power station.

The rapid expansion of solar photovoltaic (PV) power generation raises concerns regarding its impact on terrestrial ecosystems. Although the influence of PV panels on soil conditions and plant biomass is acknowledged, their effects on the assembly processes and co-occurrence networks of soil microbial communities remain understudied. Clarifying this influence is crucial for understanding the effects of photovoltaic panels on soil ecosystem functions.

The role of telomere shortening in ambient ozone exposure-related insulin resistance.

Background: Ozone (O) exposure and telomere shortening are associated with insulin resistance (IR). However, the role of telomere shortening in ambient O exposure-related IR is largely unclear.

Methods: The Henan Rural Cohort recruited participants and performed a random forest method to estimate residential O concentration.

Zebrafish Larvae as a Predictive Model for the Risk of Chemical-Induced Cholestasis: Phenotypic Evaluation and Nomogram Formation.

Chemical-induced cholestasis (CIC) has become a concern in chemical safety risk assessment in pharmaceutical, food, cosmetic, and industrial manufacturing. Currently, known animal and liver models are unsuitable as high-throughput screening tools due to their high cost, time-consuming, or poor screening accuracy. Herein, a cohort of chemicals validated as cholestatic hepatotoxic in humans, rodents, and liver models was established for testing.

Structural characteristics and potential antidepressant mechanism of a water-insoluble β-1,3-glucan from an edible fungus Wolfiporia cocos.

A water-insoluble β-1,3-glucan (Wβ) with a molecular weight of 8.12 × 10 Da was extracted from an edible fungus Wolfiporia cocos. Its backbone was composed of 1,3-β-linked Glcp branched at the C-2, C-4, and C-6 positions, connecting more 1,3-β-linked Glcp with a triple helical structure.

Pathways linking loneliness and depressive symptoms among Chinese adolescents: The mediating role of sleep disturbance.

Background: Despite growing evidence linking loneliness and depressive symptoms, the underlying pathways remain unclear. This study aims to assess the impact of loneliness on depressive symptoms among Chinese adolescents and investigate the potential mediating role of sleep disturbance.

Methods: A cross-sectional study was conducted between November and December 2021.

Dissociable Default Mode Network Connectivity Patterns Underlie Distinct Symptoms in Psychosis Risk.

The Clinical High Risk (CHR) stage of psychosis is characterized by subthreshold symptoms of schizophrenia including negative symptoms, dysphoric mood, and functional deterioration. Hyperconnectivity of the default-mode network (DMN) has been observed in early schizophrenia, but the extent to which hyperconnectivity is present in CHR, and the extent to which such hyperconnectivity may underlie transdiagnostic symptoms, is not clear. As part of the Shanghai At-Risk for Psychosis (SHARP) program, resting-state fMRI data were collected from 251 young adults (158 CHR and 93 controls, M = 18.

Network analysis of resilience, anxiety and depression in clinical nurses.

Background: Resilience is a protective feature against anxiety and depression disorders. However, the precise relationship and structure of resilience and anxiety and depression remain poorly understood. This study sought to investigate the link among resilience' components and anxiety as well as depression.

Contribution of soil microbial necromass carbon to soil organic carbon in grassland under precipitation change and its influencing factors in loess hilly region, Northwest China.

To investigate the contribution of microbial necromass carbon (MNC) to soil organic carbon (SOC) and its influencing factors under precipitation changes in grassland, we conducted a precipitation experiment with seven different precipitation levels in the restoration area in the loess hilly region. We analyzed the contents and characteristics of fungal necromass carbon (FNC), bacterial necromass carbon (BNC), and MNC in different fractions of SOC under different treatments, including natural precipitation (CK), and increased and decreased 20%, 40%, 60% of natural precipitation (I, I, I, D, D, D) . The results showed that 1) MNC content in mineral organic carbon (MAOC) ranged from 1.

Development Trends and Prospects of Technology-Based Solutions for Health Challenges in Aging Over the Past 25 Years: Bibliometric Analysis.

Background: As the global population ages, we witness a broad scientific and technological revolution tailored to meet the health challenges of older adults. Over the past 25 years, technological innovations, ranging from advanced medical devices to user-friendly mobile apps, are transforming the way we address these challenges, offering new avenues to enhance the quality of life and well-being of the aging demographic.

Objective: This study aimed to systematically review the development trends in technology for managing and caring for the health of older adults over the past 25 years and to project future development prospects.

Integrative microbiome and metabolome profiles reveal the impacts of periodontitis via oral-gut axis in first-trimester pregnant women.

Background: Periodontitis results from host-microbe dysbiosis and the resultant dysregulated immunoinflammatory response. Importantly, it closely links to numerous systemic comorbidities, and perplexingly contributes to adverse pregnancy outcomes (APOs). Currently, there are limited studies on the distal consequences of periodontitis via oral-gut axis in pregnant women.