Antifungal Activity and Mechanism of Diaporthein B against in Prevention of Apple Ring Rot.

Apple ring rot, caused by the pathogenic fungus , has inflicted substantial economic losses and caused significant food safety concerns. In this study, a pimarane-type diterpenoid, diaporthein B (DTB), isolated from a marine-derived fungus, exhibited significant antifungal activity against , with an EC value of 8.8 μg/mL.

A study of the low-protein diet in delaying the course of chronic kidney disease.

A low-protein diet (LPD) has become an important way to delay the progression of chronic kidney disease (CKD) and to delay the need for dialysis. A review of the literature reveals the low-protein diet's influence on the course of chronic kidney disease. An artificial low-protein food, wheat starch, for example, can not only increase the high-quality protein intake ratio, but can ensure adequate energy intake on a low-protein diet while meeting the nutritional needs of the body, effectively reducing the burden on the damaged kidneys.

Subcellular Nanobionic Liposome with High Zeta Potential Enhances Intravesical Adhesion and Drug Delivery.

The administration of drugs resident to counteract fluid washout has received considerable attention. However, the fabrication of a biocompatible system with adequate adhesion and tissue penetration capability remains challenging. This study presents a cell membrane-inspired carrier at the subcellular scale that facilitates interfacial adhesion and tissue penetration to improve drug delivery efficiency.

Construction of tissue-engineered vascular grafts with enhanced patency by integrating heparin, cell-adhesive peptide, and carbon monoxide nanogenerators into acellular blood vessels.

Small-diameter tissue-engineered vascular grafts (sdTEVGs) have garnered significant attention as a potential treatment modality for vascular bypass grafting and replacement therapy. However, the intimal hyperplasia and thrombosis are two major complications that impair graft patency during transplantation. To address this issue, we fabricated the covalent-organic framework (COF)-based carbon monoxide (CO) nanogenerator-and co-immobilized with LXW-7 peptide and heparin to establish a multifunctional surface on TEVGs constructed from acellular blood vessels for preventing thrombosis and stenosis.

Long-term aspirin administration suppresses inflammation in diabetic cystopathy.

Diabetic cystopathy (DCP) is one of the most common and troublesome urologic complications of diabetes mellitus, characterized by chronic low-grade inflammatory response. However, the correlation between inflammation and disease progression remains ambiguous and effective drugs interventions remain deficient. Herein, during 12-week study, 48 male Sprague-Dawley rats were randomly assigned to four groups: negative control (NC), NC treated with aspirin (NC+Aspirin), DCP, and DCP treated with aspirin (DCP+Aspirin).

Site-selective growth and plasmonic spectral properties of L-shaped Janus Au-Ag gold nanodumbbells for surface-enhanced Raman scattering.

Ligand-mediated interface control has been broadly applied as a powerful tool in constructing asymmetric multicomponent nanoparticles (AMNP), and induces the anisotropic growth with fine-tuning morphology, composition, plasmonic property and functionality. As a new kind of AMNP, the synthesis of Janus Au-Ag nanoparticles with tunable negative surface curvature is still a challenge. Here, we demonstrate that the synergistic surface energy effects between gold nanodumbbells (Au NDs) with a negative surface curvature and 4-mercaptobenzoic acid (4-MBA) can direct the site-selective growth of anisotropic silver domains on gold nanodumbbells (Au NDs@Ag NPs).

Long-Lived Photoacid-Doped Conducting Composites Induce Photocurrent for Efficient Wound Healing.

Electrical stimulation is an effective strategy for facilitating wound healing. However, it is hindered by unwieldy electrical systems. In this study, a light-powered dressing based on long-lived photoacid generator (PAG)-doped polyaniline composites is used, which can generate a photocurrent under visible light irradiation to interact with the endogenous electric field and facilitate skin growth.

Minimally invasive nephrolithotomy versus retrograde intrarenal surgery in surgical management of Lower calyceal stones: a systematic review with meta-analysis.

Objective: The efficacy and safety of minimally invasive nephrolithotomy (MPCNL) versus retrograde intrarenal surgery (RIRS) was assessed for lower calyceal (LC) stones.

Methods: Our team conducted a systematic literature search up to December, 2022, using PUBMED, EMBASE and the Cochrane Library. The study was registered in PROSPERO, CRD 42021247197.

Efficacy and safety of the surgical treatments for lower calyceal stones: a systematic review and network meta-analysis.

Objective: Efficacy and safety of five common surgical treatments for lower calyceal (LC) stones were assessed for LC stones 20 mm or less.

Methods: A systematic literature search was conducted up to June 2020 using PubMed, EMBASE, and Cochrane Library. The study has been registered in PROSPERO, CRD42021228404.

Occupational Exposures and Health Risks of Benzene, Toluene, and Xylenes (BTX) in Automobile Repair Industry in Beijing City, China.

This study aimed to evaluate the occupational health risks of benzene, toluene, and xylenes (BTX) exposure in the automobile repair industry in Beijing city in China. The concentrations of BTX were monitored at 140 operating positions of 51 randomly selected automobile repair enterprises in 2018. Samples analysis showed that all monitoring concentrations were not higher than the occupational exposure limits.

Heterodimensional superlattice with in-plane anomalous Hall effect.

Superlattices-a periodic stacking of two-dimensional layers of two or more materials-provide a versatile scheme for engineering materials with tailored properties. Here we report an intrinsic heterodimensional superlattice consisting of alternating layers of two-dimensional vanadium disulfide (VS) and a one-dimensional vanadium sulfide (VS) chain array, deposited directly by chemical vapour deposition. This unique superlattice features an unconventional 1T stacking with a monoclinic unit cell of VS/VS layers identified by scanning transmission electron microscopy.

Anti-inflammation properties of resveratrol in the detrusor smooth muscle of the diabetic rat.

Purpose: In this paper, we aimed to prove that resveratrol can inhibit inflammation in the detrusor smooth muscle of diabetic rats, which may provide a new direction for diabetic cystopathy (DCP) treatment.

Methods: We induced a Sprague-Dawley (SD) rat model of type 1 diabetes by intraperitoneal injections of streptozotocin (STZ). Then, we separated the SD rats into four groups: (1) an excipient-treated control group; (2) a resveratrol-treated control group; (3) an excipient-treated streptozotocin (STZ)-injected group; and (4) a resveratrol-treated STZ-injected group.

A Novel M7G-Related MicroRNAs Risk Signature Predicts the Prognosis and Tumor Microenvironment of Kidney Renal Clear Cell Carcinoma.

M7G modification is extremely vital for the development of many cancers, especially tumor immunity. M7G modification is a novel functional regulator of miRNA, and the researches on m7G-related miRNAs in kidney renal clear cell carcinoma (KIRC) are still insufficient. This research aims to establish a risk signature on the foundation of m7G-associated miRNAs, which can precisely forecast the prognosis of KIRC patients.

Marine fungal metabolites as a source of drug leads against aquatic pathogens.

Aquatic pathogens, including Vibrio, Edwardsiella, Pseudomonas, and Aeromonas, which could result in bacterial diseases to aquaculture, have seriously threatened the world aquaculture production. Marine-derived fungi, which could produce novel secondary metabolites with significant antibacterial activity, may be an important source for finding effective agents against aquatic pathogens. In this review, a systematically overview of the harm of several aquatic pathogens, and 134 antibacterial secondary metabolites against aquatic pathogens from 13 genera of marine-derived fungi, were summarized and concluded.

Pressure-driven electronic phase transition in the high-pressure phase of nitrogen-rich 1H-tetrazoles.

High-energy-density materials (HEDMs) require new design rules collected from experimental and theoretical results and a proposed mechanism. One of the targeted systems is the nitrogen-rich compounds as precursors for possible polymeric nitrogen or its counterpart in a reasonable pressure range. 1H-tetrazole (CHN) with hydrogen bonds was studied under pressure by both diffraction and spectroscopy techniques.

Construction of a Linked Data Set of COVID-19 Knowledge Graphs: Development and Applications.

Background: With the continuous spread of COVID-19, information about the worldwide pandemic is exploding. Therefore, it is necessary and significant to organize such a large amount of information. As the key branch of artificial intelligence, a knowledge graph (KG) is helpful to structure, reason, and understand data.

Novel polymerization of nitrogen in zinc nitrides at high pressures.

Nitrogen-rich compounds containing polynitrogen are attractive candidates for high-energy-density materials. In this work, using first-principles calculations and a particle swarm optimization structural search method, four novel nitrogen-rich structures are predicted at high pressures, i.e.

Pressure-induced novel nitrogen-rich aluminum nitrides: AlN, AlN and AlN with polymeric nitrogen chains and rings.

Pressure-induced non-molecular phases of polymeric nitrogen have potential applications in the field of energetic materials. Here, through a structural search method combined with first-principles calculations, we have predicted four novel nitrogen-rich aluminum nitrides C2/m-AlN6, Cm-Al2N7, C2-Al2N7 and P1-AlN7. Nitrogen atoms polymerize into infinite chains in C2/m-AlN6, C2-Al2N7 and P1-AlN7 structures and form N3 chains and N4 rings in Cm-Al2N7.

Decomposition mechanism on different surfaces of copper azide.

Copper azide, a potential primary explosives that may replace traditional primers such as lead azide, mercury fulminate and silver azide, has received widespread attention, but its decomposition mechanism remains unclear. Here, based on first-principles calculations, (010), (100)and (001) facets with a copper/nitrogen atom ratio of 1/6 are found to be the most stable surfaces of copper azide crystal. Through transition state (TS) calculations, we find that during the decomposition process on the surface, there is a synergy effect between two Cu-N1-N2-N3 chains, where the terminal N2-N3 bonds on two chains break simultaneously, and the dissociated N3 atom bonds with another N3' atom of adjacent chain to form a N molecule.