Publications by authors named "Hui-shun Lu"
We developed a maternal fetal rat model to study the effects of isoflurane-induced neurotoxicity on the fetuses of pregnant rats exposed in utero. Pregnant rats at gestational day 14 were exposed to 1.3 or 3% isoflurane for 1h.
View Article and Find Full Text PDF[Effects of gestational isoflurane exposure on postnatal memory and learning in rats].
Zhejiang Da Xue Xue Bao Yi Xue Ban
January 2012
Article Synopsis
- The study aimed to examine how exposure to isoflurane during pregnancy affects the memory and learning abilities of rat pups, focusing on specific proteins related to growth and neuropeptide expression in the hippocampus.
- Twelve pregnant rats were divided into two groups: one exposed to isoflurane and a control group, with their offspring's memory assessed using the Morris Water Maze after four weeks.
- Results showed that pups from the isoflurane group had worse performance in memory tests and lower levels of growth-associated protein-43 (GAP-43) and neuropeptide Y (NPY) in the hippocampus compared to the control group.
Emerging evidence has demonstrated that exposure to anesthetics early in life caused neurohistopathologic changes and persistent behavioral impairments. In this study, a maternal fetal rat model was developed to study the effects of isoflurane exposure during pregnancy on postnatal memory and learning in the offspring. Pregnant rats at gestational day 14 were either exposed to 1.
View Article and Find Full Text PDFPurpose: Variability in drug responses could result from both genetic and environmental factors. Thus, drug effect could depend on geographic location, although regional variation is not generally acknowledged as a basis for stratification. There is evidence that the pharmacokinetic set developed in a European population for the target-controlled infusion (TCI) of propofol does not apply in Chinese patients; however, we are not aware of previous studies comparing the estimated concentration-bispectral index (BIS) response of Caucasian patients in Europe with that of Chinese patients in China.
View Article and Find Full Text PDF[Effect and mechanism of ropivacaine on the isolated human umbilical artery].
Zhonghua Yi Xue Za Zhi
January 2010
Objective: To investigation the effect of ropivacaine on the contraction of the isolated human umbilical artery and the mechanisms involved.
Methods: Endothelium-denuded human umbilical artery rings obtained from healthy full-term parturients were prepared. Using isometric force transducers and a fluorometer, the effect of ropivacaine in cumulative concentration on the contraction response induced by KCl in the presence or absence of verapamil, or verapamil plus ruthenium red or verapamil plus heparin was observed.