[Clinicopathologic features and differential diagnosis of splenic B-cell marginal zone lymphoma involving bone marrow].

Objective: To study the clinicopathologic features and differential diagnosis of splenic B-cell marginal zone lymphoma (SMZL) involving bone marrow.

Methods: The clinical and pathologic features of 22 patients with SMZL were retrospectively studied. Immunophenotypic analysis was carried out by flow cytometry and immunohistochemistry.

[Clinical observation of treating 62 patients with severe aplastic anemia failing in immunosuppressive therapy by integrative medicine].

Objective: To explore treatment methods for patients with severe aplastic anemia (SAA) failing in immunosuppressive therapy (IST).

Methods: Totally 62 SAA patients failing in IST were treated by integrative medicine (IM). The treatment course was divided into three stages: the critical emergency stage, the improvement stage, and the recovery stage.

[Analysis of clinical features and prognosis of primary myelodysplastic syndromes with myelofibrosis patients].

Objective: To analyze the clinical features and prognosis of the primary myelodysplastic syndrome with myelofibrosis (MDS-MF) patients and to improve the cognition of MDS-MF.

Methods: Four hundred and sixty-six primary MDS patients with bone marrow (BM) biopsy were divided into two groups according to whether BM associated with fibrosis, the clinical features and prognosis of the two groups were analyzed retrospectively.

Results: 167 (35.

[Clinicopathologic features of aggressive natural killer cell leukemia].

Objective: To study the clinicopathologic features of aggressive natural killer cell leukemia (ANKL).

Methods: The clinical and pathologic features were analyzed in 10 patients with ANKL. The complete blood count, peripheral blood smears, bone marrow aspirates and bone marrow biopsies were studied.

[Clinicopathologic study of 15 splenectomy specimens of patients with hairy cell leukemia].

Objective: To investigate the clinicopathologic features, diagnosis, differential diagnosis and the prognosis of hairy cell leukemia (HCL).

Methods: Fifteen splenectomy specimens of HCL patients were investigated retrospectively using HE and immunohistochemistry in correlation with the follow-up information.

Results: (1) The male to female ratio was 2.

[Blastic plasmacytoid dendritic cell neoplasm: two cases report and review of literatures].

Objective: To identify the clinical and pathological features of blastic plasmacytoid dendritic cell neoplasm (BPDC).

Methods: The characteristics of BPDC hematodermic neoplasm were discussed with a report of two new cases and review the literatures.

Results: Both patients presented with skin nodules and the tumors were CD(4)(+) and CD(56)(+).

[Clinicopathologic features of peripheral T-cell lymphoma, unspecified with follicular pattern].

Objective: To study the clinicopathologic features of peripheral T-cell lymphoma, unspecified (PTL-U) with follicular pattern.

Methods: The clinical data, hematoxylin and eosin-stained sections of lymph node biopsies and follow-up data of 18 cases of PTL-U associated with follicular growth pattern were reviewed and studied. Eight cases of reactive lymphoid hyperplasia were used as controls.

[Bone marrow microvessel density and vascular endothelial growth factor expression in patients with aplastic anemia].

Objective: To study the bone marrow microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression and their clinical significance in patients with aplastic anemia (AA).

Methods: Bone marrow biopsies in 51 newly diagnosed patients with AA were evaluated the MVD and VEGF expression by immunostaining with anti-factor VIII related antigen and VEGF monoclonal antibodies at regular time points after immunosuppressive therapy (IT).

Results: The mean bone marrow MVD in AA group was 5.

[Development of Sweet syndrome in an acute promyelocyte leukemia patient during treatment with all-trans retinoic acid--case report and literature review].

Objective: To identify the side effect of all-trans retinoic acid (ATRA), and improve early therapeutic response in patients with acute promyelocytic leukemia (APL).

Method: The first case of Sweet's syndrome (SS) developed in a APL patient treated with ATRA was reported in mainland of China, and reviewed correlative literature.

Results: Only 14 cases of SS associated with ATRA therapy in APL have been reported in the literature, including the present case.

Ultrastructural characteristics of bone marrow in patients with hematological disease: a study of 13 cases.

There are few transmission electron microscopic studies on bone marrow biopsies of patients with hematological disease owing to the difficulty of overcoming the artifacts of decalcification. Following the fixation of bone marrow biopsies thoroughly before a mild decalcification procedure, ultrastructural studies were performed on 13 patients with varied hematological diseases. Notable features included blood cell disorganization, fibroblast activation, myofibroblast transformation, as well as accumulation of collagen and extracellular amorphous matrix.

[Natural killer-like T-cell lymphoma/leukemia--a case report and literature review].

Objective: To identify the clinical and pathological features of natural killer-like T-cell lymphoma/leukemia.

Methods: The characteristics of natural killer-like T-cell lymphoma/leukemia was discussed with report a new case and review of literatures.

Results: A 16-year-old girl was referred to our hospital because of fever and disseminated cutaneous herpes and ulcer.

[Study of 161 chronic idiopathic myelofibrosis patients for clinicopathological staging].

Objective: To investigate the significance of clinicopathological stage of chronic idiopathic myelofibrosis (CIMF) in WHO classification of 2001.

Methods: Histopathological analysis of bone marrow biopsy plastic-embedded sections stained with H-G-E and Gomori's stains and clinical features of 113 cases previously diagnosed as primary myelofibrosis (PMF) and 48 cases MPD-U (total of 161 cases which including male 79 and female 82) were studied retrospectively.

Results: There was no significant differences on the clinical features among the cellular phase, collagen fiber phase, sclerotic phase and osteomyelosclerosis of 113 previously diagnosed patients.

[Advances of bone marrow biopsy pathology in diagnosing lymphoma bone marrow involvement].

The diagnosis of lymphoma bone marrow involvement (LBMI) is mainly based on bone marrow biopsy. Pathology of LBMI in Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL) are different. The morphology, distribution patterns and immunophenotype of most tumor cells in bone marrow are consistent with those in extramedullary sites, but few may show some discrepancy.

[Clinical features and prognostic factors in primary myelofibrosis patients under 45 years old].

Objective: To investigate the clinical and hematological features and identify the prognostic factors associated with short-term survival in primary myelofibrosis (PMF) patients under 45 years old.

Methods: The clinical manifestations, laboratory parameters, and survival were retrospectively analyzed in 56 PMF patients under 45 years old. Univariate analysis of prognostic factors was performed using Logrank test and multivariate analysis using COX model.

[The clinical features of hepatitis associated aplastic anemia].

Objective: To analyse the proportion of hepatitis associated aplastic anemia (HAAA) in severe aplastic anemia (SAA) and its clinical features of HAAA.

Methods: All newly diagnosed SAA cases in our department in the recent 5 years were analyzed. A case-control study was undertaken to investigate the differences of clinical and laboratory features between HAAA and non-hepatitis associated SAA (non-HASAA) patients.

[Clinical and laboratory study of a case of hematidrosis].

Objective: To study the clinical characteristics and pathogenesis of hematidrosis.

Methods: Detailed clinical manifestations and natural history of a patient with hematidrosis were presented. A series of laboratory examinations were performed, and skin pathohistologic features and ultra microscopic structures were observed.

[Observation on treatment of post-remission acute myeloid leukemia patients by lingxiong piaoling powder and longchan cigu decoction].

Objective: To explore the effect of the treatment for long-term disease-free survival (DFS) of post-remission patients with acute myeloid leukemia (AML).

Methods: Twenty-nine AML patients with completely remission (CR) and 17 with partial remission (PR) were treated with Chinese medicine, Longchan Cigu Decoction 1 dose per day and Lingxiong Piaoling Powder 7 doses per month, and combined with DA or HA regimen of chemotherapy one course per year. Patients peripheral blood picture, bone marrow smear, biopsy and human leukocyte antigen DR (HLA-DR) cells were examined before and after treatment, and their disease-free survival (DFS) was followed up.

[Morphologic and clinical study of 131 cases of plasma cell myeloma].

Objective: To study the characteristics histologic and cytologic features and clinical usefulness of plasma cell myeloma (PCM) subtyping according to WHO PCM classification.

Methods: Bone marrow biopsy plastic-embedded sections were stained with H-G-E and Gomori's stains, and bone marrow aspirate smears were stained with Wright's stain. The clinicopathologic findings were then analyzed.

[Hemangioblastic characteristics of fetal bone marrow-derived Flk1+ CD34- cells].

Objective: To investigate whether fetal bone marrow stromal cells have hemangioblastic characteristics.

Methods: Human fetal bone marrow stromal cells (hfMSCs) were isolated and cultured. Immunophenotypes of hfMSCs were tested by FACS.