Publications by authors named "Hui-min Guo"
Objective: To explore the differences in the effectiveness of various teaching methods combining online and offline modes in paediatric medical education.
Methods: Fourth-year medical paediatric students at our university in 2020 were randomly divided into three groups: a control group, experimental group 1, and experimental group 2, with 30 students in each group. The control group received traditional teaching, experimental group 1 received a combination of online and offline teaching using two methods simultaneously, and experimental group 2, in addition to the methods used in experimental group 1, engaged in real-case teaching in the ward.
Article Synopsis
- - The study examined the effectiveness of evidence-based preoperative nursing interventions on reducing postoperative infections and ICU stay length for liver transplant patients, comparing an intervention group to a control group receiving standard care.
- - Results showed that while the intervention group had a significantly lower infection rate (13.80%) compared to the control group (33.30%), there was no significant difference in ICU stay length between the two groups (both had an average of 3 days).
- - While the outcomes did not significantly improve post-intervention, the study highlighted better compliance and awareness among healthcare providers, emphasizing the importance of using evidence-based practices in nursing care for liver transplant patients.
Article Synopsis
- Labor epidural analgesia (LEA) may alter gut microbiota in mothers and newborns, according to a study that examined this relationship.
- The study involved 21 mothers who received LEA and 24 control mothers, with fecal samples analyzed for gut microbiota composition using advanced gene sequencing.
- Results indicated significant changes in gut microbiota diversity and specific correlations between LEA and various microbial profiles in both mothers and their infants, highlighting the need for further research on the clinical implications.
Article Synopsis
- The study aims to analyze research on infectious disease nursing in China, assessing the current state of knowledge in this field.
- A bibliometric analysis was conducted on 4,693 literature pieces retrieved from multiple databases, revealing an increase in publications, particularly peaking in 2010, primarily funded by provincial-level research grants.
- Key areas of focus included various aspects of infection control and nursing care, with emerging trends highlighting the importance of "quality nursing" and "infection control" after 2015, suggesting future research may expand on these topics.
Article Synopsis
- The study aimed to evaluate if peroral endoscopic myotomy (POEM) enhances esophageal movement in achalasia patients and to examine the relationship between patient characteristics and recovery of this movement.
- A total of 103 patients were analyzed, with findings showing decreased Eckardt scores, lower esophageal sphincter (LES) resting pressure, and improved contractile activity post-POEM, indicating improved symptoms.
- Key indicators for improved recovery included lower pre-procedural LES resting pressure and Eckardt scores, while those with better recovery experienced fewer instances of gastroesophageal reflux-related issues.
Article Synopsis
- - The study investigated the use of specific bacteria found in feces as potential early diagnostic markers for gastric cancer (GCa), focusing on samples from 1043 patients in China.
- - Significant findings included the detection of two bacteria, Streptococcus anginosus and Streptococcus constellatus, which showed higher levels in both gastric cancer tissues and fecal samples, making them reliable indicators for both early and advanced GCa.
- - The fecal bacterial signature exhibited high sensitivity and specificity in distinguishing early GCa from more advanced stages, suggesting it could serve as a noninvasive method for early cancer detection.
Article Synopsis
- The study investigates how exogenous glutathione (GSH) impacts ischemic stroke in rats, focusing on its therapeutic effects and the underlying mechanisms, particularly through quantitative proteomic analysis.
- Rats underwent a middle cerebral artery occlusion (MCAO) followed by treatment with GSH or L-dopa/carbidopa, with findings indicating that tyrosine metabolism and dopaminergic synapses are key pathways involved in stroke and GSH's therapeutic action.
- The treatment with L-dopa/carbidopa not only improved neurological function and reduced brain damage but also enhanced GSH levels by increasing its synthesis, suggesting potential combined therapeutic strategies for stroke recovery.
Analysis of coal mine occupational disease hazard evaluation index based on AHP-DEMATEL.
Arch Environ Occup Health
December 2021
Article Synopsis
- - The analysis of occupational-disease-inductive factors in coal mines aims to safeguard workers' health and minimize losses due to occupational diseases.
- - A comprehensive assessment framework was created based on the energy release cause model, leading to the establishment of an evaluation index system for occupational disease hazards in coal mines.
- - The AHP-DEMATEL evaluation model revealed that the developed indicator system effectively reflects real-world occupational hazard management practices in coal mining, demonstrating its reliability and flexibility.
Article Synopsis
- The study analyzes the effectiveness of locking intramedullary nails compared to locking plates in treating complex proximal humeral fractures involving the humeral shaft.
- A total of 40 cases were reviewed over an average follow-up period of about 35 months, assessing various clinical outcomes.
- Results showed that both methods yielded good long-term functional results, but locking intramedullary nails had advantages in terms of less blood loss, shorter operation time, and smaller incision length.
Article Synopsis
- The silkworm (Linnaeus) is crucial for economic purposes and serves as a key model for studying reproduction and development in insects, particularly Lepidoptera.
- Exposure to the chemical insecticide pyriproxyfen negatively impacts silkworm reproduction by reducing the number of eggs, hatching rates, and ovarian tissue development.
- Gene expression analysis revealed that pyriproxyfen exposure significantly lowered the transcription levels of genes involved in ovary development and hormone regulation, leading to reproductive disorders in silkworms.
Article Synopsis
- * Researchers identified 45 rice mutants with strong resistance to BPH from a large population, focusing on the role of the mitochondrial outer membrane protein 64 (OM64).
- * The OM64 gene deficiency increased resistance to both BPH and SSB by enhancing hydrogen peroxide signaling and jasmonic acid biosynthesis, without impacting rice yield, highlighting its potential as a target for improving pest resistance.
Article Synopsis
- The study aimed to analyze the types of non-typeable Haemophilus influenzae (NTHi) and changes in their resistance to β-lactam antibiotics over the past decade.
- NTHi isolates from 2013-2014 showed higher resistance levels compared to those from 2003-2004, with over half of the isolates being β-lactamase-positive and significant amino acid changes observed in key resistance genes.
- The research concluded that β-lactam-resistant NTHi strains have increased significantly and that the genetic mutations related to resistance have become more varied and complex over time.
Article Synopsis
- - This study evaluates the effectiveness and safety of endoscopic submucosal dissection (ESD) for treating laterally spreading tumors involving the dentate line (LST-DL) compared to those not involving it (LST-NDL).
- - A total of 49 patients with LST-DL and 96 with LST-NDL were analyzed; results showed similar en bloc resection rates but longer procedure times and higher complications like perianal pain for LST-DL cases.
- - The findings suggest that while ESD is a safe and effective option for LST-DL, it requires skilled endoscopists due to its complexities.
Article Synopsis
- The study investigates the controversial use of antioxidants, specifically glutathione (GSH), in combination with the chemotherapy drug doxorubicin (DOX), focusing on its effects on toxicity and efficacy during treatment.* -
- Research using both animal models and cancer cell lines reveals that while GSH can reduce the cardiotoxic and hepatotoxic effects of DOX, it also diminishes DOX's anticancer effectiveness without affecting the drug's concentration in tumors.* -
- The findings suggest that combining GSH with DOX in chemotherapy should generally be avoided, except in situations where DOX has caused significant liver or heart damage.*
The Variant rs145204276 of GAS5 is Associated with the Development and Prognosis of Gastric Cancer.
J Gastrointestin Liver Dis
March 2018
Article Synopsis
- Down-regulation of the GAS5 long non-coding RNA is linked to increased cell growth in gastric cancer (GC), indicating a poorer prognosis for patients.
- A study involving 1,253 GC patients and 1,354 healthy controls found that the del/del genotype of the GAS5 variant rs145204276 was less frequent in GC patients and associated with higher survival rates.
- Results highlighted that patients at later tumor stages had a significantly lower rate of the del/del genotype, suggesting its potential role in cancer progression and metastasis.
[Exogenous H₂O₂ regulated secondary metabolism of Scutellaria baicalensis and enhanced drug quality].
Zhongguo Zhong Yao Za Zhi
January 2018
Article Synopsis
- Increased demand for Chinese materia medica has shifted from wild to cultivated sources, affecting the quality of these medicinal materials.
- The study found that treating leaves of Scutellaria baicalensis with H₂O₂ caused a decline in certain antioxidant enzyme activities but enhanced the biosynthesis of flavonoids.
- After treatment with low concentrations of H₂O₂, there was a notable increase in flavonoid content, specifically baicalein and wogonin, indicating potential methods to improve the quality of cultivated medicinal herbs.
Article Synopsis
- * A study on male rats revealed that realgar NPs led to increased liver enzyme levels and fat accumulation, indicating hepatotoxicity.
- * Metabolomics analysis identified significant changes in serum and liver metabolites, helping differentiate the effects of realgar NPs from other treatments and contributing to understanding nanotoxicity.
Article Synopsis
- - The study investigates how anisotropic surface tension affects the nucleation and growth of particles in a ternary alloy melt, providing a mathematically valid solution for temperature, concentration, and interface evolution.
- - The results show that the critical radius for nucleation depends on factors like isotropic surface tension and temperature undercooling, and that solute diffusion reduces this critical radius.
- - After nucleation, the particle's interface initially experiences inward and outward growth due to surface tension effects, leading to a distinctive ear-like deformation before stabilizing as solidification progresses.
Insomnia in Adults With Chronic Hepatitis B, Liver Failure, and Cirrhosis: A Case-Control Study.
Perspect Psychiatr Care
January 2017
Article Synopsis
- The study aimed to evaluate how common insomnia is among patients with chronic hepatitis B (HBV) and its complications, compared to healthy individuals.
- It involved 120 patients and 40 healthy controls, measuring symptoms of depression, anxiety, and different types of insomnia.
- Results showed that 64.2% of patients experienced at least one type of insomnia, with urban living correlating with reduced insomnia, suggesting a need for increased focus on insomnia in clinical care for these patients.*
Article Synopsis
- - The brown planthopper (BPH) is a major pest for rice crops, and while jasmonic acid (JA) boosts defenses against chewing pests, it hampers defenses against BPH.
- - Researchers found that overexpressing an enzyme called allene oxide cyclase (AOC) increased rice's resistance to BPH, mainly by cutting down on the insect's feeding and survival, independent of the JA pathway.
- - The study suggests that boosting levels of a compound called OPDA can enhance rice's defenses against BPH and may also work on other pests, highlighting a potential agricultural strategy for improving crop resilience.
Article Synopsis
- The study aimed to assess the effectiveness of F-FDG PET/CT and MRI in detecting lymph-node metastasis in early-stage cervical cancer through a review of 87 patients.
- Results showed that PET/CT outperformed MRI significantly in terms of sensitivity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy for both node-based and patient-based metastases.
- The findings conclude that PET/CT is a more reliable imaging method than MRI for identifying lymphatic metastases in early-stage cervical cancer patients.
Article Synopsis
- Evaluating soil respiration variability in apple orchards helps understand the impact of converting cropland to orchards, with a study conducted at the Changwu State Key Agro-Ecological Station between 2011 and 2012.
- Soil respiration was measured at different distances from the tree trunk, showing that it decreased as the distance increased; specifically, it was 20% to 31% higher at 0.5 m compared to 2 m from the trunk.
- The study found that while soil temperature influenced seasonal changes in soil respiration, it couldn't explain spatial variations, suggesting root density plays a significant role and highlighting the importance of distance from the trunk when assessing soil respiration rates.
Article Synopsis
- - The study aimed to develop a precise and sensitive method to explore the chemical components of the Fuzi-Gancao herb pair and Fuzi alone to better understand their interactions.
- - An ultra-fast liquid chromatography-mass spectrometry method was designed to analyze and identify the phytochemicals in both herbs, revealing fifty-one compounds, mostly types of alkaloids.
- - Results indicated that certain alkaloid types increased when the herbs were combined, providing insights for quality control and further research on their compatibility mechanisms.
Article Synopsis
- The study aimed to evaluate how effective endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) are for treating superficial esophageal cancer (SEC).
- A meta-analysis of eight studies revealed that ESD had better outcomes in terms of en bloc and curative resection rates, and lower local recurrence rates compared to EMR.
- Despite these advantages, ESD had longer operative times and higher perforation rates, while both methods showed similar rates for esophageal stricture and bleeding complications.
Article Synopsis
- The study aimed to evaluate the outcomes of peroral endoscopic myotomy (POEM) in Chinese Han patients with achalasia, focusing on symptom relief and other health metrics over at least one year post-surgery.
- Results showed significant improvements with a lower Eckardt score indicating better symptom relief, decreased lower esophageal sphincter (LES) pressure, and enhanced quality of life measured through SF-36 scores.
- Although POEM is effective for treating achalasia, some complications occurred, including cutaneous emphysema and mucosal injury.