Publications by authors named "Hui-ling Sun"

Stroke-associated infection (SAI) is a major medical complication in acute ischemic stroke patients (AIS) treated with endovascular therapy (EVT). Three hundred thirty-three consecutive patients with AIS caused by a large vessel occlusion in the anterior circulation who received EVT (142 (42.6%) of them were given IV tPA as bridging therapy) and 337 AIS patients who received IV tPA only (non-EVT) were enrolled in the study and evaluated to determine the association of inflammatory factors on admission with SAI.

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  • The study investigates the role of microRNA-142-3p (miR-142-3p) in breast cancer, revealing that its expression is significantly lower in tumor tissues and cell lines compared to normal levels.* -
  • Elevating miR-142-3p expression was found to inhibit both the growth and spread of breast cancer cells, as demonstrated through experiments both in vitro (in the lab) and in vivo (in live models).* -
  • The mechanism involves the regulation of RAC1 protein levels by miR-142-3p, which subsequently affects proteins related to cancer progression, suggesting that targeting the miR-142-3p/RAC1/PAK1 pathway could offer new treatment
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The ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) is an objective approach to predicting poor outcomes in acute ischemic stroke (AIS). The impact of TG/HDL-C on hemorrhagic transformation (HT) after AIS remains unknown. The aim of this study was to explore the accurate effect of TG/HDL-C on HT after AIS.

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Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC.

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  • Researchers identified distinct patterns of lncRNA expression using microarray analysis and qRT-PCR, revealing 70 up-regulated and 128 down-regulated lncRNAs in IS patients compared to healthy controls and those with transient ischemic attack (TIA).
  • A lncRNA-based biomarker panel showed strong potential for diagnosing IS, outperforming traditional markers like BDNF and NSE, particularly in tracking disease progression and severity post-treatment.
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Tumor-infiltrating lymphocytes (TILs) are white blood cells that have left the bloodstream and migrated into a tumor, involving in the prognosis of breast cancer (BC) patients. Published studies reported the value of TILs in patients with HER2-positive receiving trastuzumab-based treatment. However, the results obtained remain controversial.

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Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs1456315, rs7463708) in the lncRNAs and the risk of female breast cancer in a Chinese population.

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Genome-wide association studies have identified that polymorphisms in 8q24 confer susceptibility to gastric cancer. Polymorphisms in the lncRNA , , and transcribed from the 8q24 locus have a potential risk for gastric cancer. To evaluate whether there is such an association in Chinese population, a case-control study enrolled 494 patients and 494 healthy controls was carried out.

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Background: Long noncoding RNA (lncRNA) Z38 has been shown to promote cell proliferation and tumorigenesis in breast cancer. However, expression pattern and prognostic value of lncRNA Z38 in breast cancer patients remain elusive.

Methods: The expression levels of SPRY4-IT1 in 110 self-paired specimens of breast cancer and adjacent normal breast tissues were measured by quantitative real-time PCR (qRT-PCR), and its correlation with overall survival of patients with breast cancer was further statistically analyzed.

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Polymorphisms in nucleotide excision repair (NER) pathway genes are associated with the risk of breast cancer, but the relevance of these associations appeared to vary according to the ethnicity of the subjects. To systemically evaluate the potential associations between NER polymorphisms and breast cancer risk in a Chinese population, we carried out a case-control study on 450 breast cancer patients and 430 healthy controls. Sequenom MassARRAY was used for genotyping, and immunohistochemistry was performed to detect estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression in tumor tissue.

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Genetic variation within microRNA (miRNA) may result in its abnormal folding or aberrant expression, contributing to colorectal turmorigenesis and metastasis. However, the association of six polymorphisms (miR-608 rs4919510, miR-499a rs3746444, miR-146a rs2910164, pre-miR-143 rs41291957, pre-miR-124-1 rs531564 and pre-miR-26a-1 rs7372209) with colorectal cancer (CRC) risk, therapeutic response and survival remains unclear. A retrospective study was carried out to investigate the association in 1358 0-III stage resected CRC patients and 1079 healthy controls using Sequenom's MassARRAY platform.

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Lung cancer is one of the leading causes of cancer death worldwide. Accumulating evidence has indicated that microRNAs (miRNAs) can be proposed as promising diagnostic and prognostic markers for various cancers. The current study analyzed the miRNA expression profiles of 418 lung adenocarcinoma (LUAD) cases obtained from The Cancer Genome Atlas dataset, with the aim to investigate the relationship of miRNAs with progression and prognosis of LUAD.

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Background: Inflammation plays an important role in the development and progression of CRC. The members of inflammatory biomarkers, preoperative NLR and PLR, have been proved by numerous studies to be promising prognostic biomarkers for CRC. However, the diagnostic value of the two biomarkers in CRC remains unknown, and no study reported the combined diagnostic efficacy of NLR, PLR and CEA.

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Purpose: The findings on the prognostic value of lymphocyte-to-monocyte ratio (LMR) in diffuse large B-cell lymphoma (DLBCL) are inconsistent. This meta-analysis was conducted to more precisely evaluate the prognostic significance of LMR in DLBCL.

Methods: This analysis combined eleven studies with 4,578 patients aiming to assess the association of LMR with overall survival (OS) and progression-free survival (PFS) in DLBCL.

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Polymorphisms in Disrupted-in-Schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1) might be associated with schizophrenia; however, the conclusions of relevant studies were inconsistent across different ethnic populations. This population-based case-control study was carried out to determine whether polymorphisms in these two genes could be associated with schizophrenia in the Chinese population. A case-control study of 248 schizophrenia patients and 236 controls was performed with the Sequenom MassARRAY platform.

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  • * A total of 13 studies with 1,623 participants were included, revealing that YKL-40 has a sensitivity of 71% and specificity of 90% for diagnosing ovarian cancer.
  • * The findings suggest that YKL-40 can be considered a reliable diagnostic tool, with a strong diagnostic odds ratio and a high area under the curve value (0.8471).
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BACKGROUND At present, whether human cytomegalovirus (HCMV) infection is associated with type 2 diabetes mellitus (T2DM) is debatable. The effect of active HCMV infection on glucose regulation has been poorly studied. Although HCMV infection is correlated with atherosclerosis in cardiovascular disease, the role of HCMV infection in the development of diabetic atherosclerosis in T2DM is unclear and is usually neglected by endocrinologists.

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  • * The research utilized Sequenom MassARRAY for genetic detection and assessed estrogen and progesterone receptors along with CerbB-2 expression through immunohistochemistry.
  • * Findings indicated that, overall, these polymorphisms were not linked to breast cancer risk, but women who had their first menstruation after age 14 and carried the rs1970801 T allele showed a lower risk of developing breast cancer.
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  • A study explored the role of a genetic variation (BIM deletion polymorphism) in affecting the effectiveness of tyrosine kinase inhibitors (TKIs) in cancer treatment, particularly focusing on 1,532 Asian patients with non-small cell lung cancer (NSCLC).
  • The meta-analysis found that this genetic variation was linked to lower response rates and shorter progression-free survival in patients with EGFR-mutated NSCLC, highlighting its potential as a predictor for TKI therapy effectiveness.
  • However, no significant relationship was observed between BIM deletion polymorphism and overall survival or adverse events in EGFR-mutated NSCLC, nor was it linked to patient outcomes in chronic myeloid leukemia (CML) and hepatoc
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  • The long non-coding RNA UCA1 is found to be overexpressed in hepatocellular carcinoma (HCC), where it correlates with tumor progression, metastasis, and patient survival outcomes.
  • Depleting UCA1 in HCC cell lines reduces both growth and metastasis, indicating its role in cancer advancement.
  • UCA1 interacts with miR-216b, disrupting its regulatory effects and leading to increased expression of FGFR1 and activation of the ERK signaling pathway, suggesting a complex regulatory network that could be targeted for HCC diagnosis and treatment.
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Epidemiological investigation have suggested that there is a significantly inverse association between circulating 25-hydroxyvitamin D (25(OH)D) and the risk for developing colorectal cancer (CRC) in humans. However, little is known about the role of vitamin D binding protein (VDBP) in colorectal carcinogenesis. Blood samples were collected from 212 CRC patients and 212 controls matched with age, gender and blood collection time.

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Accumulating evidences indicate cancer-triggered inflammation plays a pivotal role in carcinogenesis. Systematic inflammatory response biomarkers are considered as potential prognostic factors for improving predictive accuracy in colorectal cancer (CRC). Preoperative neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (d-NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte- to-monocyte ratio (LMR) were investigated and compared in 205 surgical CRC patients.

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  • E-Cadherin (CDH1) gene variations may affect cancer invasion and metastasis by changing transcriptional activity in epithelial cells, but studies on its link to cancer risk are inconsistent due to differing lifestyles and genetics.
  • A meta-analysis of 57 studies found that three specific CDH1 polymorphisms (-160 C>A, -347 G>GA, and 3'-UTR +54 C>T) were significantly associated with cancer risk, with varying effects depending on the type of cancer.
  • Results indicated that the -160 A allele increases prostate cancer risk, while it may decrease colorectal cancer risk; the -347 GAGA genotype heightens overall cancer risk, particularly in colorectal cancer among Asians, while the +
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