Publications by authors named "Hui-jun Zhu"
Background: While timely assessment of long-term survival for patients with bone cancer is essential for evaluation on early detection and prognosis level of treatment of bone cancer, those data are extremely scarce in China. We aimed to timely and accurately assess long-term survival for patients with bone cancer in Eastern China.
Methods: Patients diagnosed with bone cancer during 2004 - 2018 from four cancer registries with high-quality data from Taizhou, Eastern China were included.
Simulation of double resonant excitation of ions in an asymmetric linear ion trap mass analyzer.
Rapid Commun Mass Spectrom
December 2023
Article Synopsis
- The study focuses on improving the analytical performance of linear ion traps (LITs) using a double resonant excitation method in an asymmetric LIT design.
- By adjusting the x electrode and applying specific alternating voltages to both x and y electrodes, researchers achieved a more efficient release of ions and better mass resolution.
- Results showed that the mass resolution increased to ~3800, more than double the previous method, while maintaining around 90% efficiency in ejecting ions, suggesting this technique could enhance ion detection in LIT mass spectrometers overall.
Article Synopsis
- The study focuses on improving the pre-operative differentiation between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) using a new deep learning model called CSAM-Net, as current imaging methods are inadequate.
- Researchers analyzed CT images from 395 HCC and 99 ICC patients and developed the CSAM-Net, which utilizes channel and spatial attention mechanisms for better accuracy.
- The CSAM-Net model demonstrated significantly higher accuracy (AUC values around 0.987 for training) in distinguishing between HCC and ICC compared to conventional models, suggesting it could be a highly effective non-invasive diagnostic tool for liver cancers.
Article Synopsis
- The study investigates how dose distribution affects the equivalent uniform dose (EUD) model in predicting radiation-induced brain injury in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (IMRT).
- It analyzes data from 103 patients, determining that an optimal volume-effect parameter can be found based on the max area under the curve (mAUC) from receiver operating characteristic (ROC) analyses, revealing that different volumes and dose levels influence predictive accuracy.
- The findings conclude that the volume-effect parameter in EUD varies with dose distribution, and using a critical-dose-volume EUD approach can enhance predictive capabilities compared to traditional dose/volume metrics.
Article Synopsis
- A study analyzed 221 patients with stage IA1-IIA1 cervical cancer to determine if adjuvant radiotherapy is needed after laparoscopic hysterectomy.
- Patients were divided into three groups: those receiving both surgery and radiotherapy (group A), those who had open surgery (group B), and those with laparoscopic surgery alone (group C).
- Results showed that groups A and B had significantly better 3-year local recurrence-free survival rates compared to group C, suggesting that adjuvant radiotherapy improves outcomes for early-stage cervical cancer, especially in stage IB patients.
Article Synopsis
- - Baicalin has various health benefits, including anti-inflammatory and antibacterial properties, but its role in treating Adriamycin-induced nephrotic syndrome (NS) isn't fully understood.
- - In a study with rats, researchers found that baicalin improved kidney function and caused significant changes in the expression of 363 genes related to EMT, fibrosis, apoptosis, and inflammation in those with Adriamycin-induced NS.
- - The findings suggest that baicalin could be a promising treatment for NS by reducing inflammation and fibrosis, indicating potential therapeutic genes for future research.
Article Synopsis
- The study examines how half-brain delineation can help predict radiation damage in the temporal lobes of patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiotherapy (IMRT).
- A retrospective analysis of 220 NPC cases showed significant differences in radiation doses received by the temporal lobes compared to half-brains, with specific dosimetric parameters demonstrating varying degrees of prediction accuracy for temporal lobe injury (TLI).
- The findings suggest that using half-brain delineation simplifies the contouring process and provides reliable estimates for TLI risk, making it a practical approach for NPC patient treatment planning.
[Establishment of Quantitative SPR Assay for Antibodies Against Human Platelet Antigen-1a].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2021
Objective: To establish quantitative surface plasmon resonance (SPR) assay for antibodies against human platelet antigen-1a (HPA-1a).
Methods: Recombinant protein was fixed on the chip surface by amino coupling method. SPR assay was used to detect the standard antibodies against HPA-1a at different conceatration.
Oridonin exhibits various pharmacological and physiological activities, including antioxidant, antibacterial, anti-inflammatory, pro-apoptotic, anticancer and neurological effects. However, its role in rheumatoid arthritis (RA) is yet to be revealed. We evaluated the effects of oridonin on the survival and autophagy of RA-fibroblast-like synoviocytes (FLSs).
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- Melittin, found in honeybee venom, shows potential as a treatment for Rheumatoid Arthritis (RA) by reducing inflammation and pain.
- This study examined melittin's effects on fibroblast-like synoviocytes (FLS) from RA patients, specifically its impact on cell survival, apoptosis, and inflammatory processes.
- Findings revealed that melittin decreases FLS viability, encourages apoptosis and autophagy, and lowers IL-1β secretion, suggesting it may help protect joints from damage in RA.
Aldehyde dehydrogenase 1 expression is correlated with poor prognosis in breast cancer.
Medicine (Baltimore)
June 2017
Article Synopsis
- Breast cancer (BC) is a prevalent cancer and a leading cause of mortality in women, with aldehyde dehydrogenase 1 (ALDH1) being a key marker related to cancer stem cells and tumor outcomes.
- This study compared ALDH1 expression levels in BC tissue samples versus noncancerous tissues, finding significantly higher mRNA and protein levels in BC.
- The analysis revealed that high ALDH1 expression correlates with worse clinicopathological features and shorter survival, suggesting it might be a valuable prognostic indicator and a potential therapeutic target for BC.
Article Synopsis
- Phosphoglycerate dehydrogenase (PHGDH) is identified as a potential oncogene in various cancers, and this study investigates its role specifically in colorectal cancer (CRC).
- Researchers analyzed PHGDH expression in CRC tissue samples and found that higher levels of PHGDH mRNA and protein were present in tumor tissues compared to normal adjacent tissues.
- High PHGDH protein levels were linked to more advanced cancer stages and poorer patient outcomes, suggesting that measuring PHGDH could help identify patients at greater risk for aggressive CRC.
Article Synopsis
- * Four different NSCLC cell lines were tested, and results showed that two lines (PC9 and HCC827) had higher uptake of [(125)I]PYK and were more sensitive to radiation compared to the other two lines (A549 and H1975).
- * Additionally, pretreatment with the drug gefitinib reduced the cell cycle S phase fraction and improved radiation effects in the more sensitive cell lines, suggesting that [(125)I]PYK could be a reliable indicator for tailoring radiotherapy in NSCLC patients
Article Synopsis
- A review of recent studies on acupuncture's effectiveness for treating stephenipodia after stroke highlights key factors such as acupoint selection, needling techniques, and timing of treatment.
- The choice of acupoints should consider anatomical relationships, and different protocols are recommended based on the phase of stephenipodia.
- Combining optimized acupuncture protocols with rehabilitation methods can significantly improve therapeutic outcomes, but further research is needed on the relationship between acupuncture effects and patient-specific factors.
Article Synopsis
- This study examined how different types of soil affect the breakdown of the pesticide dufulin, focusing on its two enantiomers, S-(+)-dufulin and R-(-)-dufulin.
- The researchers used high-performance liquid chromatography (HPLC) to analyze the stability and degradation of these enantiomers, finding that they remained stable and did not convert into each other in nonsterile soil conditions.
- Results indicated that dufulin degraded faster in nonsterile soils due to microbial activity, with the S-(+)-enantiomer degrading more quickly than the R-(-)-enantiomer, suggesting that using S-(+)-dufulin could be less harmful to the environment.
Assessment of epidermal growth factor receptor status in glioblastomas.
Asia Ocean J Nucl Med Biol
July 2016
Objectives: Our previous study showed that a newly designed tracer radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline ([(125)I]PYK) is promising for the evaluation of the epidermal growth factor receptor (EGFR) status and prediction of gefitinib treatment of non-small cell lung cancer. EGFR is over-expressed and mutated also in glioblastoma. In the present study, the expressions and mutation of EGFR were tested with [(125)I] PYK in glioblastoma in vitro and in vivo to determine whether this could be used to predict the sensitivity of glioblastoma to gefitinib treatment.
View Article and Find Full Text PDF[The role of acupuncture and moxibustion in organized medicine of pain].
Zhongguo Zhen Jiu
June 2013
Article Synopsis
- Recent studies show that acupuncture-moxibustion works well for various types of pain on its own.
- Combining acupuncture-moxibustion with other treatments can enhance its effectiveness.
- Integrating acupuncture-moxibustion into organized medical pain management can reduce costs and improve patient quality of life, but more research is needed to support specific applications.
Article Synopsis
- 5-aza-2'-deoxycytidine (5-aza-CdR) is an anticancer drug that can reactivate the tumor suppressor gene CDX2 in gastric cancer, leading to improved survival rates in patients expressing CDX2.
- In gastric cancer tissues, higher levels of DNA methyltransferase 1 (DNMT1) correlate with advanced disease features, while CDX2 expression is inversely related to DNMT1, suggesting that DNMT1 silences CDX2.
- Treatment with 5-aza-CdR demethylates the CDX2 promoter, increases its expression, reduces DNMT1 levels, and leads to inhibited cell growth and increased apoptosis in gastric cancer cell
Article Synopsis
- This study aimed to evaluate GC-C mRNA expression in the peripheral blood of gastric carcinoma patients to see if it could serve as a marker for predicting cancer spread and assessing patient status.
- Researchers analyzed blood samples from 60 gastric cancer patients, 21 with dysplasia, 15 with intestinal metaplasia, and 20 healthy individuals, finding that GC-C mRNA levels were significantly higher in cancer patients compared to the others.
- The findings suggest that the elevated GC-C mRNA levels correlate with various clinical factors like tumor stage and lymph node involvement, indicating it might serve as a promising prognostic marker for gastric carcinoma.
The molecular mechanisms leading to gastric carcinogenesis still remain unclear. Recently, several studies demonstrated that over-expression of guanylyl cyclase C (GCC) has been detected in intestinal-type gastric cancer (GC) and precursor lesions. Our objective was to explore the expression levels of GCC and endogenous ligands guanylin (GN) and uroguanylin (UGN) and the correlation between Helicobacter pylori (H.
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- This study aimed to investigate how otopoint-needle embedment affects migraines and its potential mechanisms.
- Ninety-two migraine patients were divided into acupuncture and medication groups, with acupuncture involving needle insertion at specific points and monitoring plasma serotonin levels before and after treatment.
- Results showed that the acupuncture group had significantly better outcomes in headache relief and serotonin levels compared to the medication group after one and six months.
Objective: To investigate the expression of guanylyl cyclase C (GCC) in human gastric cancer (GC) tissues and assess the effect of GCC small interfering RNA (siRNA) on the proliferation and apoptosis of SGC-7901.
Methods: The expression of GCC in 30 specimens and three human GC cell lines (SGC-7901, AGS, NCI-N87) were detected by RT-PCR for messenger RNA (mRNA) by Western blot and immunofluorescence for proteins. Recombinant plasmids containing GCC siRNA and scrambled siRNA were constructed and transfected into SGC-7901 cells, respectively.
Objective: To investigate the expression of guanylyl cyclase-C (GC-C) and caudal type homeobox transcription factor 2 (CDX2) in human gastric mucosa at different stages and the significance thereof.
Methods: An Immunofluorescence method was used to detect the expression of GC-C and CDX-2 in 23 specimens of gastric carcinoma and matching noncancerous tissues. Western blotting was used to detect the protein expression of GC-C and CDX2 in the gastric carcinoma tissues and matching noncancerous tissues too.