Construction of chitosan hydrochloride-carboxymethyl chitosan nanoparticles using anti-solvent method for the co-delivery of puerarin and resveratrol.

The applications of resveratrol (RES) and puerarin (PUE) with notable physiological functions are greatly limited in functional food and pharmaceutical industries due to their poor water solubility and chemical instability. Accordingly, co-loading of RES and PUE into chitosan-based nanoparticles (NPs) is performed here by an anti-solvent method to improve their bioavailability. The fabricated NPs at 8:1 mass ratio of carboxymethyl chitosan (CMC) to chitosan hydrochloride (CHC) with the particle size of 375.

Characteristic Activation Pattern and Network Connectivity of Prefrontal Cortex in Patients with Type 2 Diabetes Mellitus and Major Depressive Disorder during a Verbal Fluency Task: A Functional Near-Infrared Spectroscopy Study Based on Network-Based Statistic Prediction.

Introduction: Type 2 diabetes mellitus (T2DM) and major depressive disorder (MDD) together occur frequently among the elderly population. However, the inconsistency in assessments and limited medical resources in the community make it challenging to identify depression in patients with T2DM. This cross-sectional study aimed to investigate the activation pattern and network connectivity of prefrontal cortex (PFC) during a verbal fluency task (VFT) in patients with T2DM and MDD using functional near-infrared spectroscopy (fNIRS).

Optimization of extraction process of polysaccharide from Phylloporia fontanesiae and its simulated digestion in vitro.

In this study, Phylloporia fontanesiae polysaccharide was successfully isolated through a sequential water extraction and alcohol precipitation process. Utilizing the Box-Behnken design, the extraction process was optimized based on single-factor experiments, considering variables such as the material-to-liquid ratio, extraction temperature, extraction time, and the number of extractions. The polysaccharide composition of P.

A Review on the Driving Forces in the Formation of Bioactive Molecules-Loaded Prolamin-Based Particles.

Prolamin-based particles loaded with bioactive molecules have attracted widespread attention from scientists due to their novel properties in chemistry, physics, and biology. In the self-assembly process of biopolymer-based nanocapsules, noncovalent interactions are the main driving forces for reducing bulk materials to the nanoscale and controlling the release of bioactive molecules. This article reviews the types of interaction forces, binding strength, binding active sites, molecular orientation, and binding affinity that affect the release profile of bioactive molecules during the preparation of protein stabilizer particles.

"Coir Raincoat"-Boosted Biomimetic Hydrogel for Efficient Solar Desalination and Wastewater Purification.

Solar-driven interfacial evaporation is an efficient method for purifying contaminated or saline water. Nonetheless, the suboptimal design of the structure and composition still necessitates a compromise between evaporation rate and service life. Therefore, achieving efficient production of clean water remains a key challenge.

Revolutionizing cancer treatment: Harnessing the power of terrestrial microbial polysaccharides.

Cancer treatment faces numerous challenges, such as inadequate drug targeting, steep price tags, grave toxic side effects, and limited therapeutic efficacy. Therefore, there is an urgent need for a safe and effective new drug to combat cancer. Microbial polysaccharides, complex and diverse biological macromolecules, exhibit significant microbial variability and uniqueness.

Chemical constituents from and their vasodilatory activities and action mechanism.

A new triterpenoid compound (scandine A1) was obtained from 95% ethanol extract of Meanwhile, eleven described compounds were also isolated for the first time from . Herein, compound exhibited strong diastolic cardio-cerebrovascular activity (EC = 9.22 μM and EC = 14.

Stereoselective Synthesis of Xylodonin A and 22-Hydroxyxylodonin A and Discovery of Analogues with Cytotoxic Activity.

The first and stereoselective synthesis of xylodonin A and 22-hydroxyxylodonin A, two drimane-type sesquiterpenoid natural products, was developed from the readily available (+)-sclareolide. This route features an allylic oxidation and acid-promoted dehydration for construction of the key intermediate 6-hydroxyisodrimenin. Representative analogues were synthesized, and their previously unknown bioactivities were revealed after biological evaluation.

Molecular and cellular pruritus mechanisms in the host skin.

Pruritus, also known as itching, is a complex sensation that involves the activation of specific physiological and cellular receptors. The skin is innervated with sensory nerves as well as some receptors for various sensations, and its immune system has prominent neurological connections. Sensory neurons have a considerable impact on the sensation of itching.

Chemical constituents from and their anti-inflammatory activities and action mechanism.

A new alkaloid * (scandine Z) and fourteen known natural products were isolated from 95% ethanol extract of for the first time. Besides compound *, these fourteen compounds were firstly isolated from . Excitedly, compound exhibited strong anti-inflammatory activity (IC = 8.

Co-encapsulation of curcumin and anthocyanins in bovine serum album-fucoidan nanocomplex with a two-step pH-driven method.

Background: Curcumin (CUR) and anthocyanins (ACN) are recommended due to their bioactivities. However, their nutritional values and health benefits are limited by their low oral bioavailability. The incorporation of bioactive substances into polysaccharide-protein composite nanoparticles is an effective way to enhance their bioavailability.

Antifouling and Self-Healing Performance of Marine Coatings Based on Hydrogen-Bond Interactions.

Biofouling is an urgent problem that has to be solved in marine industries. As the traditional antifouling coating loses its antifouling ability after being damaged, the introduction of self-healing performance into the antifouling coating becomes a high priority. Accordingly, we report here a self-healing and antifouling polyurethane composite coating (PCL/MPU-Si/M) with the use of its carbonyl groups as multiple hydrogen bond acceptors.

Divergent and Stereoselective Synthesis of Ustusal A, (-)-Albrassitriol, and Elegansin D.

The first synthesis of ustusal A as well as expeditious access to (-)-albrassitriol is described as featuring a singlet oxygen [4 + 2] cycloaddition, achieving the desired stereoselectivity for the 1,4--hydroxyl groups. Transformation of (+)-sclareolide to followed by a key Horner-Wadsworth-Emmons (HWE) reaction and stereospecific allylic oxidation facilitated the first synthesis of elegansin D. The biological evaluation of these natural products together with seven elegansin D analogues was performed, among which several elegansin D analogues exhibited potential anticancer activity against liver cancer HepG2 cells (IC = 11.

Comprehensive analysis of different types of ginsenosides in the different parts of American ginseng by targeted and nontargeted MS/MS scanning.

To comprehensively study the ginsenosides distribution in the various tissues of American ginseng, the qualitative and quantitative-targeted and nontargeted mass spectroscopic methods were established using the high-performance liquid chromatography coupled with Qtrap triple quadrupole mass spectrometry (HPLC-QtrapQQQ-MS). The total ginsenosides of the root, stem, and leaf of American ginseng were determined by a colorimetric method, and the contents showed the order from high to low root, stem, and leaf. Eighty-two kinds of ginsenosides were detected in the different parts of American ginseng by enhanced mass scan-information-dependent data acquisition (IDA)-enhanced product ion (EPI) scan mode, including 69 from the root, 62 from the stem, and 48 from the leaf.

Co-encapsulation of curcumin and resveratrol in zein-bovine serum albumin nanoparticles using a pH-driven method.

In the present study, zein-bovine serum albumin (BSA) composite nanoparticles (NPs) are produced with the use of a pH-driven method. The mass ratio of BSA to zein has a significant impact on the particle size, but exhibits a limited effect on the surface charge. With an optimal zein/BSA weight ratio of 1 : 2, zein-BSA core-shell NPs are fabricated for the single/co-loading of curcumin and resveratrol.

Comprehensive evaluation of corrosion inhibition performance and ecotoxicological effect of cinchona IIa as a green corrosion inhibitor for pickling of Q235 steel.

Here, to prevent the corrosion of Q235 steel in the pickling and discover novel green corrosion inhibitors, the corrosion inhibition performance and eco-toxicity of cinchonain IIa were evaluated. Electrochemical experiments confirms that 200 mg/L cinchonain IIa reveals good corrosion inhibition performance with 94.08% on Q235 steel in HCl for 48 h.

Processing technologies, phytochemistry, bioactivities and applications of black ginseng-a novel manufactured ginseng product: A comprehensive review.

Black ginseng is a novel manufactured ginseng product, and the application of black ginseng products in market is increasing in recent years. Black ginseng is prepared by steaming and fermentation, but not as mature as processing red ginseng. Therefore, complete proposals for preparation techniques are firstly presented.

Total Synthesis of Marine Natural Products (+)-Strongylin A and Corallidictyal D by Regio- and Stereoselective Cyclization of Alkenyl Benzenes.

An expeditious access to marine natural products (+)-strongylin A and corallidictyal D is described. A TFA/EtSiH-induced reductive isomerization of enols to alkenyl benzenes followed by a selectivity-controlled cyclization in the presence of HCl and BF·EtO affords benzofuran and benzopyran , respectively. The applicability of this HCl-induced cyclization is showcased by a regio- and stereoselective synthesis of corallidictyal D, while BF·EtO-promoted cyclization posterior to rearrangement of an alkenyl benzene provides a regioselectively different benzopyran, (+)-strongylin A.

Fabrication of foxtail millet prolamin/caseinate/chitosan hydrochloride composite nanoparticles using antisolvent and pH-driven methods for curcumin delivery.

Co-assembled foxtail millet (FP)-sodium casein (NaCas) nanocomplex and NaCas coated FP nanoparticles (NPs) were produced by using pH-cycle and anti-solvent methods, respectively. Subsequently, the effects of chitosan hydrochloride (CHC) coating on the particle size, surface charge and physicochemical stability of the two different FP/NaCas nanoparticles (NPs) were evaluated. With the addition of CHC, the particle size of NaCas coated FP NPs and co-assembled FP-NaCas nanocomplex significantly increased from 128.

Environmentally benign cinchonain IIa from Uncaria laevigata for corrosion inhibition of Q235 steel in HCl corrosive medium: Experimental and theoretical investigation.

Traditional corrosion inhibitors make great contribution to metal protection, but also cause environmental pollution. To solve the problem, plant extracts as green corrosion inhibitors have attracted much attention in recent years. Plants are good raw materials for corrosion inhibitors and also meet the requirements of industry.

Single/co-encapsulation capacity and physicochemical stability of zein and foxtail millet prolamin nanoparticles.

In the last few decades, zein has been extensively studied owing to its wide commercial availability and the ability to self-assemble into nanosphere structure to encapsulate biologically active substances for targeted delivery. This work emphasized on comparing the encapsulation efficiency of hydrophobic active biomolecules and the physicochemical stability of composite nanoparticles (NPs) made up of zein- and foxtail millet prolamin (FP) -caseinate. Puerarin, resveratrol, diosmetin, and curcumin with various LogP values were selected as model drugs to study the single/co-encapsulation capacity, storage stability, and in vitro release profiles.

Mesoporous crosslinked chitosan-activated clinoptilolite biocomposite for the removal of anionic and cationic dyes.

A mesoporous crosslinked chitosan-activated clinoptilolite biocomposite (CS-GA/ACP) was prepared with chitosan (CS) as the substrate and glutaraldehyde (GA) as the crosslinking agent. Structural analysis of the CS-GA/ACP composite beads was performed using FTIR, SEM, and BET techniques. The adsorption properties of the CS-GA/ACP for Congo red (CR) and methylene blue (MB) removal were examined using a batch method.