H19 is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting miR-2-3p.

A great number of studies have confirmed that long noncoding RNA (lncRNA) are involved in the regulation of inflammatory response in acute gouty arthritis (AGA). This paper aimed to survey the regulatory mechanism of H19 on AGA. The expression of serum H19 in all subjects was examined by qRT-PCR.

Long non-coding RNA SND1-IT1 accelerates cell proliferation, invasion and migration via regulating miR-132-3p/SMAD2 axis in retinoblastoma.

Long noncoding RNAs (lncRNAs) have been identified as prognostic biomarkers and functional regulators in human tumors. In our study, we aim to investigate the roles of lncRNA SND1-IT1 (SND1-IT1) in retinoblastoma (RB). We observed that SND1-IT1 was highly expressed in both RB specimens and cells, and associated with poorer prognosis of RB patients.

Rotundic acid ameliorates non-alcoholic steatohepatitis via SREBP-1c/ SCD1 signaling pathway and modulating gut microbiota.

Non-alcoholic steatohepatitis (NASH) is a devastating form of non-alcoholic fatty liver disease (NAFLD) with distinguished hallmarks of steatosis and inflammation. Rotundic acid (RA) is a natural pentacyclic triterpene compound extracted from the bank of Ilex rotunda Thunb with a wide range of biological activities. The aim of the study is to evaluate the pharmacological effect and action mechanism of RA on NASH in vitro and in vivo.

Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain.

Voltage-gated sodium channel Nav1.7 robustly expressed in peripheral nociceptive neurons has been considered as a therapeutic target for chronic pain, but there is no selective Nav1.7 inhibitor available for therapy of chronic pain.

Prognostic factors affecting the short-term efficacy of non-surgical treatment of chronic periodontitis: a multilevel modeling analysis.

Background: This study is aimed to analyze the prognostic factors affecting the short-term efficacy of non-surgical treatment of patients in periodontitis from stage II to stage IV by the multilevel modeling analysis.

Materials And Methods: A total of 58 patients with chronic periodontitis were included in this study. Patients were clinically explored before and 3 months after the treatment and the difference in probing depth was determined [Reduction of probing depth (Δ PD) = baseline PD - finial probing depth (FPD)] which is considered as the therapeutic evaluation.

Two new cephalochromin derivative from the sp. ZG22.

Two new cephalochromin derivatives, prenylcephalochromin A (), prenylcephalochromin B (), along with cephalochromin () were isolated from the sp. ZG22 obtained from a collected from the Hainan. The structures of two new compounds were elucidated by comprehensive spectroscopic methods.

Structural variation of the complete chloroplast genome and plastid phylogenomics of the genus Asteropyrum (Ranunculaceae).

Two complete chloroplast genome sequences of Asteropyrum, as well as those of 25 other species from Ranunculaceae, were assembled using both Illumina and Sanger sequencing methods to address the structural variation of the cp genome and the controversial systematic position of the genus. Synteny and plastome structure were compared across the family. The cp genomes of the only two subspecies of Asteropyrum were found to be differentiated with marked sequence variation and different inverted repeat-single copy (IR-SC) borders.

The synergistic effect of cobalt on a Pd/Co catalyzed Suzuki-Miyaura cross-coupling in water.

This work introduces the new trimetallic complex CoPd(HBPDC)Cl·(HO)(HBPDC = 2,2'-bipyridine-4,4'-dicarboxylic acid) as a highly efficient and more cost-effective catalyst for a Suzuki-Miyaura reaction proceeding in water, without additives and under aerobic conditions. Catalytic studies revealed a synergistic Co-Pd cooperativity, fostered by ligation through HBPDC, and accounting for the superior performance of the heterobimetallic complex vs. its Co-free counterpart.

[IDH1 Gene Mutation and Its Clinical Significance in patients with Acute Myeloid Leukemia].

Objective: To evaluate the incidence rate of IDH1 in acute myeloid leukemia and analyze its effect on clinical characteristics and prognosis.

Methods: Mononuclear cells in bone marrow samples were collected from 192 adult patients with newly diagnosed AML. Polymerase chain reaction (PCR) and direct sequencing were used to amplify exon 4 of IDH1 gene, the gene sequencing was used to analyze the gene mutations, at same time, the detection of NPM1, FLT3-TKD, FLT3-ITD, C-KIT, CEPBA, TET2 and JAK2V617F and MLL mutations were carried out, the follow-up was used to determine its therapeutic efficacy and outcomes of patients.

[Ecological compensation standard in Dongting Lake region of returning cropland to lake based on emergy analysis].

The annual emergy and currency value of the main ecological service value of returning cropland to lake in Dongting Lake region from 1999 to 2010 was calculated based on emergy analysis. The calculation method of ecological compensation standard was established by calculating annual total emergy of ecological service function increment since the starting year of returning cropland to lake, and the annual ecological compensation standard and compensation area were analyzed from 1999 to 2010. The results indicated that ecological compensation standard from 1999 to 2010 was 40.

[Comparison of organic component and di-n-butyl phthalate between human milk and cow milk products].

Objective: To explore types of organic components and pollution level of di-n-butyl phthalate (DBP) between human milk and cow milk products.

Methods: Forty healthy postpartum women with an average age of (27.44 ± 3.

Screening of PAH-degrading bacteria in a mangrove swamp using PCR-RFLP.

There are abundant PAH-degrading bacteria in mangrove sediments, and it is very important to screen the high efficiency degraders in order to perform bioremediation of PAH polluted environments. In order to obtain the more highly efficient PAH-degrading bacteria from a mangrove swamp, we first obtained 62 strains of PAH-degrading bacteria using traditional culture methods and based on their morphological characteristics. We then used the modern molecular biological technology of PCR-RFLP, in which the 16S rDNA of these strains were digested by different enzymes.

The effect of different acclimation temperatures on the prophenoloxidase system and other defence parameters in Litopenaeus vannamei.

Water temperature changes (higher and lower than 24 degrees C) were shown to have a significant effect on dopamine (DA) concentration, haemocyte count and the proPO system in the white shrimp Litopenaeus vannamei. No significant difference in any of the parameters was observed in the control group. DA concentration in haemolymph in the experimental groups increased to a peak value at 0.

Dynamic expression of pepsinogen C in gastric cancer, precancerous lesions and Helicobacter pylori associated gastric diseases.

Aim: To investigate the relationship between the expression of pepsinogen C (PGC) and gastric cancer, precancerous diseases, and Helicobacter pylori (H pylori) infection.

Methods: The expression of PGC was determined by immunohistochemistry method in 430 cases of gastric mucosa. H pylori infection was determined by HE staining, PCR and ELISA in 318 specimens.

[Expression of pepsinogen C in gastric cancer and its precursor].

Objective: To investigate the dynamic expression of pepsinogen C (PGC) and its value in detection of precursor and gastric cancer.

Methods: Immunohistochemistry was used to examine the expression of PGC in 424 biopsy specimens of stomach mucosa collected by gastroscopy.

Results: The positive rate of PGC expression in 54 cases of normal gastric mucosa was 100% and 2.

Association between pepsinogen C gene polymorphism and genetic predisposition to gastric cancer.

Aim: To identify a molecular marker for gastric cancer, and to investigate the relationship between the polymorphism of pepsinogen C (PGC) gene and the genetic predisposition to gastric cancer.

Methods: A total of 289 cases were involved in this study. 115 cases came from Shenyang area, a low risk area of gastric cancer, including 42 unrelated controls and 73 patients with gastric cancer.