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Publications by authors named "Hui-feng Ding"

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Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model.
De-gang Yu Hui-feng Ding Yuan-qing Mao Ming Liu Bo Yu

Acta Pharmacol Sin

March 2013

Article Synopsis
  • The study aimed to determine if strontium ranelate (SR) could help reduce cartilage damage and bone changes in osteoarthritis (OA) in rats.
  • The researchers induced OA in rats using a medial meniscal tear operation and administered two dosage levels of SR for either 3 or 6 weeks, assessing cartilage health and bone properties afterward.
  • High-dose SR was found to significantly protect against cartilage degeneration and subchondral bone remodeling, unlike the low-dose SR, indicating its potential as a treatment for OA.
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Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model.
De-gang Yu Bo Yu Yuan-qing Mao Xin Zhao Xiao-qing Wang Hui-feng Ding

Acta Pharmacol Sin

July 2012

Aim: To investigate whether the stage of osteoarthritis (OA) progression influenced the efficacy of the third-generation bisphosphonate zoledronic acid in a rat medial meniscal tear model.

Methods: Medial meniscal tear (MMT) was surgically induced in adult male Sprague Dawley rats. Zoledronic acid (ZOL, 100 μg/kg, sc, twice a week) was administered starting immediately, early (from 4 weeks) or late (from 8 weeks) after OA induction.

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Synopsis of recent research by authors named "Hui-feng Ding"

  • - Hui-feng Ding's recent research primarily focuses on the therapeutic effects of novel antiosteoporotic agents, such as strontium ranelate and zoledronic acid, in the context of osteoarthritis (OA) in animal models.
  • - Significant findings indicate that strontium ranelate can effectively reduce cartilage degeneration and subchondral bone remodeling in a rat model of OA, suggesting its potential as a treatment option.
  • - The research also highlights that the timing of zoledronic acid administration in relation to OA progression significantly influences its efficacy, indicating the importance of disease stage in treatment outcomes.

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