Publications by authors named "Hui-Zhi Fan"
The chromatin remodeling gene AT-rich interactive domain-containing protein 1A (ARID1A) encodes the protein BAF250a, a subunit of human SWI/SNF-related complexes. Recent studies have identified ARID1A as a tumor suppressor. Here, we show that ARID1A expression is reduced in gastric cancer (GC) tissues, which are significantly associated with local lymph node metastasis, tumor infiltration and poor patient prognosis.
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- Hemoglobin A1c (HbA1c) is an important marker used to check for diabetes, but a new form called GSS-HbA1c hasn't been studied much yet.
- Researchers used special techniques to separate and analyze different types of hemoglobin in blood samples to understand GSS-HbA1c better.
- They found that GSS-HbA1c affects the measurement of HbA1c levels in blood, which is important for diagnosing diabetes correctly.
Article Synopsis
- We created a new method called MRB-PAGE to separate different types of human hemoglobins, which are proteins in our blood that carry oxygen.
- This method is different from traditional techniques because it uses unique buffer solutions, allowing hemoglobins to stack up and move more efficiently.
- Our experiments showed that MRB-PAGE allows us to see three clear zones of hemoglobins, which is much better than the old method that only showed one zone, making it a promising technique for labs.
Purpose: To investigate the differential proteins and related molecular mechanism of CDA-II (cell differentiation agent-II) induced therapy on a human hepatocellular carcinoma model in nude mice with high metastatic potential (LCI-D20).
Methods: After tumors were transplanted 11 days, mice were intraperitoneally injected with CDA-II (1,800 mg/kg) for 20 days continuously. The tumor growth-inhibitory efficiency in CDA-II treated groups was calculated.
Aim: To evaluate the inhibitory effect of simvastatin via investigating the overall expression level of proteins in the artery of atherosclerotic rabbit.
Methods: Experimental model was established by feeding the rabbits a high fat diet (cholesterol 0.5 g.
Aim: To study the overall protein expression changes induced by oxidized low-density lipoprotein (ox-LDL) in the U937 foam cells.
Methods: Foam cell model was established by incubating the human monoblastic leukemia (U937) cells with ox-LDL. Each protein samples in U937 control cells and U937 foam cells were separated by two-dimensional gel electrophoresis (2-DE).