Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF-B/MAPK Signaling Pathways.

Corosolic acid (CA) is the main active component of and has been known to serve as several different pharmacological effects, such as antidiabetic, anti-oxidant, and anticancer effects. In this study, effects of CA on the hepatic lipid accumulation were examined using HepG2 cells and tyloxapol (TY)-induced hyperlipidemia ICR mice. CA significantly inhibited hepatic lipid accumulation via inhibition of SREBPs, and its target genes FAS, SCD1, and HMGCR transcription in HepG2 cells.

Transparent uniaxial anisotropic spherical particles designed using radial anisotropy.

Based on Mie scattering theory and the assumption that the particle is electrically small in size (k(t)a≪1,k(m)a≪1), an analytic relationship between radial and tangential permittivity parameters has been established for achieving minimal scattering from an arbitrary rotationally uniaxial anisotropic spherical object incident by a plane wave. Analysis of fields in both the far- and near-field zones indicates that the derived relation is not only valid for electrically small particles, but also applicable to larger ones whose sizes are comparable with the free space wavelength after slight adjustments in parameters. Furthermore, it is observed that the dielectric spherical particle of reduced tangential permittivity yields better transparency performance than the design using a plasmonic cover by Alu and Engheta [Phys.