Evaluation of the effectiveness of ex-situ stabilization for arsenic and antimony contaminated soil: Short-term and long-term leaching characteristics.

Ex-situ stabilization for As and Sb co-contaminated soil was conducted through an iron-based stabilizer, PFSC (a mixture of polymerized ferric sulfate (PFS) and hydrated lime (Ca(OH)) with a dry mass ratio of 2:1). After field aging for one week, the stabilized contaminated soil was subjected to a horizontal vibration leaching test (HJ 557), Wenzel's sequential extraction, and a semi-dynamic leaching test (ANS 16.1).

A strategy to discover lead chemome from traditional Chinese medicines based on natural chromatogram-effect correlation (NCEC) and natural structure-effect correlation (NSEC): Mahonia bealei and Mahonia fortunei as a case study.

Lead compound is an important concept for modern drug discovery. In this study, a new concept of lead chemome and an efficient strategy to discover lead chemome were proposed. Compared with the concept of lead compound, lead chemome can provide not only the starting point for drug development, but also the direction for structure optimization.

A strategy to discover selective α-glucosidase/acetylcholinesterase inhibitors from five function-similar citrus herbs through LC-Q-TOF-MS, bioassay and virtual screening.

The lack of direct connection between traditional herbal medicines and multiple biological targets is a bottleneck in herbal research and quality evaluation. To solve this problem, a strategy for the discovery of active ingredients from function-similar herbal medicines based on multiple biological targets was proposed in this article. The technical route includes chromatographic separation, mass spectrometry analysis, enzymatic activity detection, pharmacophore analysis and molecular docking.