[Research progress of novel preparations of polysaccharides].

Polysaccharides are macromolecular compounds linked by multiple monosaccharides or monosaccharide derivatives, with a variety of biological activities, such as anti-tumor, anti-oxidation, anti-virus, immunity enhancement, hypoglycemic, hypolipidemic. Its complex structure, diverse biological activities, good application prospects and broad sources of polysaccharides have attracted more and more researchers. The application of microcapsules, microspheres, nanoparticles, liposomes and other new preparation techniques in the preparation research and development of polysaccharides will not only improve the stability and bioavailability of polysaccharides, but also have a good targeting in the treatment of diseases and high biocompatibility.

Prediction of drug-pathway interaction pairs with a disease-combined LSA-PU-KNN method.

Prediction of new associations between drugs and targeting pathways can provide valuable clues for drug discovery & development. However, information integration and a class-imbalance problem are important challenges for available prediction methods. This paper proposes a prediction of potential associations between drugs and pathways based on a disease-related LSA-PU-KNN method.