Publications by authors named "Hui-Wen Jia"
Epidemiological, clinical, and histological presentation of celiac disease in Northwest China.
World J Gastroenterol
March 2022
Article Synopsis
- - The study investigates celiac disease (CD) in northwest China, using data from 2,884 patients with gastrointestinal symptoms to understand its epidemiological, clinical, and pathological characteristics.
- - Among these patients, 50 were diagnosed with CD, with a higher detection rate in Kazakh individuals compared to other ethnic groups, and common symptoms including chronic diarrhea, anemia, and weight loss were reported.
- - Endoscopy findings showed significant gastrointestinal changes in CD patients, but differences in infection rates between CD and non-CD patients were not statistically significant, highlighting the need for more research in this area.
Article Synopsis
- Ulcerative colitis (UC) is a major type of inflammatory bowel disease that's notably prevalent in the Xinjiang region of China, with different symptoms seen in Uyghur and Han patients.
- The study analyzed tissue samples to identify potential biomarkers by examining the expression of miRNAs and mRNAs and predicting target genes.
- Ultimately, two miRNAs (hsa-miR-141-5p and hsa-miR-378a-5p) and three genes (ARNTL2, CLDN1, and SLC6A14) linked to the varying symptoms of UC in the two populations were identified, suggesting their potential as biomarkers.
Association of infection with colorectal polyps and malignancy in China.
World J Gastrointest Oncol
May 2020
Article Synopsis
- Gastric infection is linked to various gastrointestinal issues like chronic gastritis and ulcers, but its connection to colorectal polyps and cancer is still debated.
- This study analyzed data from nearly 4,000 patients with colorectal polyps and over 300 with cancer to explore this relationship, focusing on factors like polyp size, pathology, and gastric infection prevalence.
- Results revealed that gastric infection was more common in patients with multiple adenomatous polyps and those with atrophic gastritis or intestinal metaplasia had a significantly higher risk of developing colorectal cancer.
Alzheimer's disease (AD) is the most common neurodegenerative disorder of the brain. It causes the slow progressive loss of cognitive functions that ultimately leads to dementia and death in the elderly. The etiology and mechanism of late-onset AD (LOAD) are poorly understood, and genetic factors might play an important role in the development of AD.
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