Publications by authors named "Hui-San Tan"
Article Synopsis
- Genome duplication can lead to polyploid plants, which have potential for innovation in evolution and crop improvement, but often struggle with fertility issues.
- Newly formed polyploids exhibit slow pollen tube growth, abnormal structure, and physiological problems that cause premature bursting and gene expression changes.
- These fertility issues can improve in evolved polyploids, with specific gene variants linked to better pollen tube performance in natural tetraploid plants.
Rationale: Identifying genetic markers for heterogeneous complex diseases such as heart failure is challenging and requires prohibitively large cohort sizes in genome-wide association studies to meet the stringent threshold of genome-wide statistical significance. On the other hand, chromatin quantitative trait loci, elucidated by direct epigenetic profiling of specific human tissues, may contribute toward prioritizing subthreshold variants for disease association.
Objective: Here, we captured noncoding genetic variants by performing epigenetic profiling for enhancer H3K27ac chromatin immunoprecipitation followed by sequencing in 70 human control and end-stage failing hearts.
Investigation of variants in estrogen receptor genes and perinatal depression.
Neuropsychiatr Dis Treat
March 2018
Objectives: Depressive symptoms are common during pregnancy and after childbirth. Estrogen levels fluctuate greatly during the course of pregnancy and may contribute to mood instability. The first aim of this case-control study was to investigate whether variants in the two estrogen receptor genes might contribute to the genetic susceptibility to pregnancy-related depression using controls that were screened for postnatal depression.
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- Perinatal depression is a common mental health issue during and after pregnancy, potentially impacting both mothers and their newborns, with genetic factors and hormonal changes possibly contributing to the risk.
- A case-control study was conducted with 725 patients of Chinese descent to analyze gene variants related to perinatal depression, comparing those diagnosed with depression to control subjects with low depression scores.
- Results showed that while certain gene variants (CRHR1 and GR) didn't have a significant link to perinatal depression, one variant (CRHR1 rs242941) did have a notable association with family history of mental illness and menstrual regularity.
Background: Depression during pregnancy or after childbirth is the most frequent perinatal illness affecting women. We investigated the length distribution of a trinucleotide repeat in RAI1, which has not been studied in perinatal depression or in the Chinese population.
Methods: Cases (n=139) with confirmed diagnosis of clinical (major) depression related to pregnancy/postpartum were recruited from the outpatient clinic.