Publications by authors named "Hui-Ru Zhu"
Background: Double-negative T (DNT) cells comprise a distinct subset of T lymphocytes that have been implicated in immune responses. The aim of this study was to characterize the peripheral DNT population in breast cancer (BC) patients.
Methods: DNT cells were isolated from the peripheral blood samples of BC patients and healthy controls by flow cytometry.
Article Synopsis
- The study aimed to assess how double-negative T (DNT) cells and T-lymphocyte subsets could help diagnose and predict outcomes in colorectal cancer (CRC) patients compared to healthy controls.
- It found that CRC patients had significantly higher levels of DNT cells and specific T-cell types, and certain combinations of biomarkers showed strong diagnostic potential.
- DNT cell percentages, along with factors like the CD4/CD8 ratio and clinical stage, were identified as important independent indicators for overall survival in CRC patients.
Article Synopsis
- Early diagnosis and treatment of CNS diseases is complicated by the blood-brain barrier, making research challenging.* -
- Brain-derived extracellular vesicles (EVs) contain specific proteins and RNAs that can serve as biomarkers for CNS diseases and be engineered to deliver therapeutic cargo.* -
- The text reviews advancements in using EVs for imaging, diagnosis, and treatment of neurological diseases, aiming to enhance their clinical application.*
Background: Although pulmonary arterial hypertension (PAH) is a fatal disease, specific drugs have been used to treat PAH. These drugs predominantly target these three pathobiological pathways: Endothelin receptor antagonist (ERA), nitric oxide (NO), and prostanoids pathways. In this review, we aimed to analyze the efficacy and safety of oral targeted treatments for PAH.
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