SRF-miR‑29b-MMP2 axis inhibits NSCLC invasion and metastasis.

MicroRNAs play key roles in tumour metastasis. miR‑29b was previously reported to act as a tumour suppressor or an oncogene in diverse cancers. However, its accurate function and mechanism in metastasis of no-small cell lung cancer (NSCLC) are not well known.

[Study on effect of heavy metal cadmium ions on the ultramicrostructure damage of Pheretima aspergillum gastrointestinal epithelial cells].

Objective: To study the effect of cadmium ions of different concentrations on gastrointestinal epithelial cells structure of Pheretima aspegillum (PA).

Methods: PA were contaminated with cadmium ions of different concentrations,and the structure of the body skin was observed, under light microscope and transmission electron microscope.

Results: With the increasing of cadmium ions concentration, a large number of lysosomal hyperplasia could be seen in the PA intestinal epithelial cells, the Golgi complex distributed around, and some Golgi complex hyperplasiaed, extended to a large bubble, microvilli, cilia arranged in irregular, disordered.

[Effects of VEGF-A/VEGF-C antisense oligodeoxynucleotide on angiogenesis, lymphangiogenesis, and tumor growth of breast cancer].

Background & Objective: Angiogenesis and lymphangiogenesis are closely related to tumor metastasis. Vascular endothelial growth factor-A (VEGF-A) is considered as an important factor in promoting angiogenesisû while VEGF-C is the most critical factor in VEGF family in promoting lymphangiogenesis, and exerts synergistic effect with VEGF-A in angiogenesis. This study was to investigate the effects of VEGF-A/VEGF-C antisense oligodeoxynucleotide (ASODN) on the angiogenesis, lymphangiogenesis, and tumor growth of breast cancer.

[Expression of vascular endothelial growth factor A and C in human breast cancer and their significance].

Background & Objective: Vascular endothelial growth factor (VEGF) family is related to angiogenesis. VEGF-A and VEGF-C are closely related to tumorigenesis and lymphatic metastasis. This study was to detect the expression of VEGF-A and VEGF-C in breast cancer, and explore their correlation to cell proliferation, microvessel density (MVD), and lymphatic metastasis of breast cancer.

Statins initiated after hypertrophy inhibit oxidative stress and prevent heart failure in rats with aortic stenosis.

Objective: Heart failure is a major and escalating public health problem. Recent studies have demonstrated that statins prevented chronic heart failure (CHF) in animal studies. However, it is unknown whether statins therapy initiated after left ventricular (LV) hypertrophy is evident can still effectively prevent CHF.