Transdermal Photothermal Sterilization and Abscess Elimination Research of BSA-CuS Nanoparticles in vivo.

The treatment of subcutaneous abscess caused by drug-resistant bacteria is facing great difficulties and receiving more attention. In this work, we employed BSA-CuS nanoparticles as a photothermal reagent to apply photothermal therapy (PTT) to combat drug-resistant bacteria in vitro and subcutaneous abscess in vivo. The BSA-CuS nanoparticles were found to be stable and biocompatible without cytotoxicity toward NIH3T3 and 4T1 cells.

Patient safety climate in general public hospitals in China: differences associated with department and job type based on a cross-sectional survey.

Objective: This study analysed differences in the perceived patient safety climate among different working departments and job types in public general hospitals in China.

Design: Cross-sectional survey.

Setting: Eighteen tertiary hospitals and 36 secondary hospitals from 10 areas in Shanghai, Hubei Province and Gansu Province, China.

Expression of human insulin gene wrapped with chitosan nanoparticles in NIH3T3 cells and diabetic rats.

Aim: To study the expression of human insulin gene wrapped with chitosan nanoparticles in NIH3T3 cells and diabetic rats.

Methods: pCMV.Ins, an expression plasmid of the human insulin gene, was constructed.

Gene therapy for type 1 diabetes mellitus in rats by gastrointestinal administration of chitosan nanoparticles containing human insulin gene.

Aim: To study the expression of human insulin gene in gastrointestinal tracts of diabetic rats.

Methods: pCMV.Ins, an expression plasmid of the human insulin gene, wrapped with chitosan nanoparticles, was transfected to the diabetic rats through lavage and coloclysis, respectively.