Evaluation of subclinical left ventricular myocardial systolic dysfunction in type 2 diabetes mellitus patients with and without diabetes peripheral neuropathy by global myocardial work.

Aims: Speckle-tracking echocardiography can non-invasively estimate myocardial work (MW) to evaluate left ventricular (LV) myocardial systolic function. The present study evaluated whether MW may detect subclinical LV myocardial systolic dysfunction in type 2 diabetes mellitus (T2DM) patients with and without diabetes peripheral neuropathy (DPN).

Methods: A total of 127 T2DM patients were included in the present study, including 67 T2DM patients with DPN.

Diagnosis, treatment and genetic analysis of a case of Alstrom syndrome caused by compoud heterozygous mutation of .

Alstrom syndrome is a rare autosomal recessive disorder disease caused by mutations in the gene, and its typical clinical manifestations include cone-rod retinal dystrophy, sensorineural deafness, obesity, insulin resistance, diabetes mellitus, hypertriglyceridemia, non-alcoholic fatty liver, dilated cardiomyopathy, and progressive hepatic and renal dysfunction. In this report, we followed up a young male patient presenting with diabetes mellitus, who was later diagnosed with blindness, deafness, hyperlipidemia, obesity, fatty liver, and insulin resistance. Genetic testing revealed a compound heterozygous mutation in from the patient, with an exon 8 c.

ClC-5 alleviates renal fibrosis in unilateral ureteral obstruction mice.

Renal fibrosis is the major feature of end-stage renal disease with high mortality. Chloride (Cl) moving along Cl channels has been suggested to play to an important role in renal function. This study aims to investigate the role of ClC-5 in renal fibrosis in unilateral ureteral occlusion (UUO) mice.

[Chemical Compositions and Source Apportionment of Road Dust in Yuncheng].

Samples of particulate sources in Yuncheng including road dust, salt lake dust, coal dust, soil dust, construction,cement dust and vehicle exhaust dust were collected. Elements, ions and carbon species in particulate sources samples were analyzed. Enrichment factors and potential ecological risk assessment were used to analyze the characteristics of road dust, and chemical mass balance model was applied to identify the source of road dust.

[Pollution characteristics of organic and elemental carbon in PM2.5 in Taiyuan].

PM2.5 samples were collected at four sampling sites to study pollution characteristics of carbonaceous aerosols in Taiyuan during winter and summer. Organic carbon (OC) and elemental carbon (EC) in PM2.

[Characteristics of organic carbon and elemental carbon in PM2.5 in Shuozhou City].

PM2.5 samples were collected at four sampling sites in Shuozhou during the heating and non-heating periods. Organic carbon (OC) and elemental carbon (EC) in PM2.

[Aerosol size distribution of organic carbon and elemental carbon on the top of coke oven and in the plant area].

In order to investigate the characteristic of organic carbon (OC) and elemental carbon (EC) in particles on the top of coke oven and in the plant area, the particle matter samples of five size fraction including < or = 1.4 microm, 1.4-2.

Evaluation of the new classification and surgical strategy for myasthenia gravis.

The aim of this study was to discuss the new methods of clinical classification and staging of patients with myasthenia gravis (MG) proposed by our group and to summarize the experiences of surgical treatment of MG with a novel incision by cutting the sternum cross-sectionally at the second intercostal level. A retrospective analysis was made for the clinical data from the patients with MG who underwent thymectomy from July 1988 to May 2009. The surgical procedures were designed into three groups, a group with Osserman classification and median incision of the sternum (Group 1), a group with MGFA typing (Myasthenia Gravis Foundation of America) and a small transverse sternal incision at the second intercostal level (Group 2), and a group with new typing and a smaller transverse sternal incision at the second intercostal level (Group 3).

The genetic profiling of preferentially expressed genes in murine splenic CD8α+ dendritic cells.

In the murine splenocytes, CD8α+ dendritic cells (abbreviated as 8+DC) and CD8α- dendritic cells (abbreviated as 8-DC) are identified with some vague features for each of them. 8+DCs but not 8-DCs cross-prime cytotoxic T cells in vivo. We aim to distinguish the two subtypes of DC based on gene expression profiling.

A novel agonistic anti-human death receptor 5 monoclonal antibody with tumoricidal activity induces caspase- and mitochondrial-dependent apoptosis in human leukemia Jurkat cells.

An agonistic antibody against TNF-related apoptosis-inducing ligand death receptor 5 (DR5) is a practicable candidate drug for antitumor therapy. In this study, a novel murine anti-human DR5 monoclonal antibody, mDRA-6(IgG1-κ), has been generated. This study aimed to explore the caspase-dependent and mitochondrial mechanisms of mDRA-6 in inducing apoptosis in human leukemia Jurkat cells.

catena-Poly[[[diaqua-terbium(III)]-μ-6-carboxy-nicotinato-μ-pyridine-2,5-di-carboxyl-ato] dihydrate].

The title compound, {[Tb(C(7)H(3)NO(4))(C(7)H(4)NO(4))(H(2)O)(2)]·2H(2)O}(n), is isotypic with the analogous Tm(III) compound [Li, Zhang, Wang & Bai (2009). Acta Cryst. E65, m411].

[Synergistic lethal effect of mDRA-6 and nimesulide on human hepatocellular cancer cell line SMMC-7721].

Background & Objective: Both mDRA-6, a monoclonal antibody of death receptor 5 (DR5) in human cells prepared by our key laboratory, and nimesulide, a specific cyclooxygenase-2 (COX-2) inhibitor, can induce apoptosis of some malignant tumor cells. This study was to investigate the lethal effects of mDRA-6 and nimesulide on human hepatocellular cancer cell line SMMC-7721, and explore the possible mechanism.

Methods: The expression of DR5 on SMMC-7721 cells was detected by flow cytometry (FCM).

[Leukemic cell apoptosis induced by anti-human DR5 monoclonal antibody mDRA-6].

Aim: To investigate the apoptotic effect of anti-human DR5 (death receptor 5 of TRAIL) monoclonal antibody mDRA-6 on leukemic cells.

Methods: The morphological changes of leukemic cells were observed by fluorescence microscope. The cytotoxic and apoptotic effects of mDRA-6 on Jurkat, HL-60 and K562 cells were detected by MTT analysis and flow cytometry with Annexin V-FITC/PI staining.

[Adriamycin enhances anti-human DR5 monoclonal antibody (mDRA-6) induced HL-60 cells apoptosis].

Objective: To investigate synergistic killing effect of anti-human DR5 (death receptor 5 of TRAIL) monoclonal antibody (mDRA-6) and adriamycin(Adr) on HL-60 cells.

Methods: mDRA-6 was prepared by immunizing BALB/c mice with DR5 protein. DR5 expression on Adr-treated HL-60 cells was detected by flow cytometry.

[Cytotoxic mechanism of anti-human death receptor 5 monoclonal antibody mDRA-6].

Aim: To investigate the cytotoxic action and its mechanism of a novel anti-human DR5 monoclonal antibody (mAb mDRA-6).

Methods: The cytotoxic action of mAb mDRA-6 on Jurkat cells and the effects of inhibitors of caspase 8 and caspase 9 on apoptosis of Jurkat cells induced with mAb mDRA-6 were detected by flow cytometry. The effects of mAb mDRA-6 on the morpha of Jurkat cells was observed by fluorescence microscope.